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These enzymes are present in essentially every organ system in the body and contribute to a multitude of physiological events. Although essential for human health, excess NADPH-oxidase-generated ROS can promote numerous pathological conditions. Herein, we summarize our current understanding of NADPH oxidases and provide an overview of how they contribute to specific human diseases.<\/jats:p>","DOI":"10.1042\/cs20060059","type":"journal-article","created":{"date-parts":[[2006,6,16]],"date-time":"2006-06-16T12:03:36Z","timestamp":1150459416000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":145,"title":["The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction"],"prefix":"10.1042","volume":"111","author":[{"given":"Mark\u00a0T.","family":"Quinn","sequence":"first","affiliation":[{"name":"Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, 59717, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary\u00a0Cloud\u00a0B.","family":"Ammons","sequence":"additional","affiliation":[{"name":"Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT, 59717, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank\u00a0R.","family":"DeLeo","sequence":"additional","affiliation":[{"name":"Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2006,6,14]]},"reference":[{"key":"2021120120455493400_B1","doi-asserted-by":"crossref","first-page":"C1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am. 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