{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:02:42Z","timestamp":1773280962879,"version":"3.50.1"},"reference-count":11,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:p>Prone positioning of patients with acute respiratory failure was first suggested over 30\u00a0years ago. In the present issue of Clinical Science, Reutershan and co-workers have studied the changes in end-expiratory lung volume in 12 patients with ARDS (acute respiratory distress syndrome) over an 8\u00a0h period following manual turning from the supine to prone position. From the data presented, the authors suggest that baseline end-expiratory lung volume could be used to identify responders, and serial measurements would permit appropriate \u2018dosing\u2019 of the therapy. Although this is an interesting study that provides data that have rarely been collected when assessing the response to prone positioning, there are a number of limitations that need to be considered. However, despite the limitations, the study does stimulate a number of important questions related not only to the use of the prone position, but also to the management of patients with ARDS in general.<\/jats:p>","DOI":"10.1042\/cs20060068","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T10:20:51Z","timestamp":1194430851000},"page":"641-643","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of the prone position in the acute respiratory distress syndrome: how should we assess benefit?"],"prefix":"10.1042","volume":"110","author":[{"given":"David\u00a0F.","family":"Treacher","sequence":"first","affiliation":[{"name":"Department of Intensive Care, St Thomas' Hospital, Guy's & St Thomas' NHS Trust, Lambeth Palace Road, London SE1 7EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2021120120361755400_B1","first-page":"143","article-title":"Comments of a devil's advocate","volume":"110","author":"Bryan","year":"1974","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021120120361755400_B2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American\u2013European Consensus Conference on ARDS Definitions, Mechanisms, Relevant Outcomes and Clinical Trial Coordination","volume":"149","author":"Bernard","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120361755400_B3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1056\/NEJMoa010043","article-title":"Effect of prone positioning on the survival of patients with acute respiratory failure","volume":"345","author":"Gattinoni","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2021120120361755400_B4","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1001\/jama.292.19.2379","article-title":"Effects of systematic prone positioning in hypoxaemic acute respiratory failure: a randomized controlled trial","volume":"292","author":"Guerin","year":"2004","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"2021120120361755400_B5","doi-asserted-by":"crossref","unstructured":"Mancebo\n              J.\n            \n            \n              Fernandez\n              R.\n            \n            \n              Blanch\n              L.\n            \n            \n          \n          A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome\n          Am. J. Respir. Crit. Care Med.\n          2006\n          \n            doi:10.1164\/rccm.200503-353OC","DOI":"10.1164\/rccm.200503-353OC"},{"key":"2021120120361755400_B6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/CS20050337","article-title":"Alveolar recruitment during the prone position: time matters","volume":"110","author":"Reutershan","year":"2006","journal-title":"Clin. Sci."},{"key":"2021120120361755400_B7","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network","volume":"342","author":"NIH ARDSNet Group","year":"2000","journal-title":"N. Engl. J. 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Care Med."},{"key":"2021120120361755400_B10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/jama.282.1.54","article-title":"Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial","volume":"282","author":"Ranieri","year":"1999","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"2021120120361755400_B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.CCM.0000149854.61192.DC","article-title":"Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury","volume":"33","author":"Parsons","year":"2005","journal-title":"Crit. 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