{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:58:06Z","timestamp":1791827886708,"version":"4.3.4"},"reference-count":32,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:p>The aim of the present study was to delineate the mechanism(s) responsible for the increased secretion of VLDL (very-low-density lipoprotein) particles in patients with FCH (familial combined hyperlipidaemia). In 194 young adults (&amp;lt;25\u00a0years of age) recruited from families with FCH, we investigated how plasma lipids, (apo)lipoproteins and BMI (body mass index) varied with age. Furthermore, we performed a 5-year follow-up study of clinical and biochemical characteristics of a subset of this population (n=85) stratified by apoB (apolipoprotein B) levels (below or above the 75th percentile adjusted for age and gender). Plasma apoB concentration (r=0.45, P&amp;lt;0.0001), triacylglycerol (triglyceride) concentration (r=0.45, P&amp;lt;0.0001), LDL (low-density lipoprotein) subfraction profile (r=\u22120.46, P&amp;lt;0.0001) and BMI (r=0.51, P&amp;lt;0.0001) were significantly associated with age. Plasma apoB concentration in the hyperapoB group was already elevated at a young age, whereas other characteristics of FCH, as observed in adults, including triacylglycerol levels &amp;gt;1.5 mmol\/l and\/or small-dense LDL, were observed only sporadically. After the 5-year follow-up, BMI increased in both groups, and this increase was associated with changes in apoB (r=0.27, P&amp;lt;0.05), triacylglycerol (r=0.30, P&amp;lt;0.01), VLDL cholesterol (r=0.22, P&amp;lt;0.05), VLDL triacylglycerol (r=0.25, P&amp;lt;0.05) and high-density lipoprotein cholesterol (r=\u22120.27, P&amp;lt;0.05). In conclusion, we have found indirect evidence of a primary, presumably genetically determined, increase in plasma apoB concentration occurring early in life of offspring from families with FCH. However, aging-related post-maturation increases in adipose tissue mass also appear to contribute to an aggravation and\/or modulation of this genetically determined apoB overproduction.<\/jats:p>","DOI":"10.1042\/cs20060234","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T09:12:33Z","timestamp":1166001153000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia"],"prefix":"10.1042","volume":"112","author":[{"given":"Ewoud","family":"ter\u00a0Avest","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan\u00a0D.","family":"Sniderman","sequence":"additional","affiliation":[{"name":"Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian\u00a0J.\u00a0H.","family":"Bredie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Wiegman","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton\u00a0F.\u00a0H.","family":"Stalenhoef","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"de\u00a0Graaf","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2006,12,11]]},"reference":[{"key":"2021120120384941500_B1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.CIR.0000081777.17879.85","article-title":"Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study","volume":"108","author":"Hopkins","year":"2003","journal-title":"Circulation"},{"key":"2021120120384941500_B2","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/ATVB.17v07.1465","article-title":"Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their non affected relatives","volume":"17","author":"Bredie","year":"1997","journal-title":"Arterioscler., Thromb., Vasc. 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