{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:05:01Z","timestamp":1790186701138,"version":"4.1.0"},"reference-count":42,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:p>Patients with heart failure or OSA (obstructive sleep apnoea) have reduced HF-HRV (high-frequency heart rate variability), indicating reduced cardiac vagal modulation, a marker of poor prognosis. CPAP (continuous positive airway pressure) abolishes OSA in patients with heart failure, but effects on daytime HF-HRV have not been determined. We hypothesized that, in patients with heart failure, treatment of coexisting OSA by CPAP would increase morning HF-HRV. In 19 patients with heart failure (left ventricular ejection fraction &amp;lt;45%) and OSA (\u226520 apnoeas and hypopnoeas\/h of sleep), HF-HRV was quantified before and 1 month after randomization to a control or CPAP-treated group. In the control group (n=7), there were no changes in HF-HRV over the 1 month study during wakefulness in the morning. In the CPAP-treated group (n=12) HF-HRV increased significantly during wakefulness in the morning [from 2.43\u00b10.55 to 2.82\u00b10.50 log(ms2\/Hz); P=0.002] due to an increase in transfer function between changes in lung volume and changes in HF-HRV (92.37\u00b196.03 to 219.07\u00b1177.14\u00a0ms\/l; P=0.01). In conclusion, treatment of coexisting OSA by nocturnal CPAP in patients with heart failure increases HF-HRV during morning wakefulness, indicating improved vagal modulation of heart rate. This may contribute to improved prognosis.<\/jats:p>","DOI":"10.1042\/cs20070172","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T11:49:18Z","timestamp":1199965758000},"page":"243-249","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea"],"prefix":"10.1042","volume":"114","author":[{"given":"Matthew\u00a0P.","family":"Gilman","sequence":"first","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0S.","family":"Floras","sequence":"additional","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"},{"name":"Toronto General Hospital\/University Health Network, Toronto, ON, Canada, M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Usui","sequence":"additional","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada, M5R 1Y8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada, M5R 1Y8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard\u00a0S.\u00a0T.","family":"Leung","sequence":"additional","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada, M5R 1Y8"},{"name":"Centre for Sleep Medicine and Circadian Biology, University of Toronto, Toronto, ON, Canada, M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u00a0Douglas","family":"Bradley","sequence":"additional","affiliation":[{"name":"Sleep and Cardiovascular Physiology Research Laboratories, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5"},{"name":"Toronto General Hospital\/University Health Network, Toronto, ON, Canada, M5G 2C4"},{"name":"Toronto Rehabilitation Institute, Toronto, ON, Canada, M5R 1Y8"},{"name":"Centre for Sleep Medicine and Circadian Biology, University of Toronto, Toronto, ON, Canada, M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,1,8]]},"reference":[{"key":"2021120120524261000_B1","first-page":"2996","article-title":"ACC\/AHA Guidelines for the evaluation and management of chronic heart failure in the adult: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"104","author":"Hunt","year":"2001","journal-title":"Circulation"},{"key":"2021120120524261000_B2","article-title":"Heart Disease and Stroke Statistics: 2003 update","author":"American Heart Association","year":"2003"},{"key":"2021120120524261000_B3","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/ajrccm.160.4.9903020","article-title":"Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure","volume":"60","author":"Sin","year":"1999","journal-title":"Am. 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