{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:34:35Z","timestamp":1791272075757,"version":"4.1.0"},"reference-count":36,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>Arginine homoeostasis is impaired in short bowel syndrome, but its supplementation in short bowel syndrome patients remains controversial. Recently, we demonstrated the benefits of citrulline supplementation by the enteral route in resected rats. Since the first step in managing short bowel syndrome is to initiate total parenteral nutrition, we hypothesized that parenteral citrulline supplementation would be more appropriate in this situation than arginine supplementation. In the present study, 24 rats were assigned to four groups. The sham group underwent transection whereas the three other groups underwent resection (R) of 80% of the small intestine. All rats were then fed exclusively by total parenteral nutrition as follows: supplementation with citrulline (R+CIT), with arginine (R+ARG) or no supplementation (R). All of the rats received isocaloric and isonitrogenous nutrition for 4\u00a0days. Nitrogen balance was measured daily. Rats were then killed and the blood was collected and the intestinal mucosa and extensor digitorum longus muscle were removed for amino acid and protein analysis. Citrulline and arginine increased mucosal protein content in the ileum (compared with sham and R, P&amp;lt;0.05). However, only citrulline prevented extensor digitorum longus atrophy (R+CIT, 130\u00b13\u00a0mg compared with R, 100\u00b16\u00a0mg and R+ARG, 110\u00b12\u00a0mg, P&amp;lt;0.05). In addition, arginine worsened nitrogen balance (R+ARG, 104\u00b146\u00a0mg\/72\u00a0h compared with R, 249\u00b169\u00a0mg\/72\u00a0h, P&amp;lt;0.05). Only citrulline was able to prevent muscle atrophy and it was achieved independently from any noticeable effect on the gut in particular because citrulline and arginine share the same effect on mucosal ileal protein content. These results suggest that citrulline should be considered as a potential supplement for total parenteral nutrition of short bowel syndrome patients.<\/jats:p>","DOI":"10.1042\/cs20070451","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T10:36:03Z","timestamp":1210329363000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Impairment of arginine metabolism in rats after massive intestinal resection: effect of parenteral nutrition supplemented with citrulline compared with arginine"],"prefix":"10.1042","volume":"115","author":[{"given":"Sylwia","family":"Osowska","sequence":"first","affiliation":[{"name":"Laboratoire de Biologie de la Nutrition, EA 2498, Facult\u00e9 de Pharmacie - Universit\u00e9 Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Neveux","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie de la Nutrition, EA 2498, Facult\u00e9 de Pharmacie - Universit\u00e9 Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France"},{"name":"Service de Biochimie, H\u00f4tel-Dieu, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Nakib","sequence":"additional","affiliation":[{"name":"Service de Biochimie, H\u00f4tel-Dieu, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lasserre","sequence":"additional","affiliation":[{"name":"Biomath\u00e9matiques et Bioinformatique, Facult\u00e9 de Pharmacie - Universit\u00e9 Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Cynober","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie de la Nutrition, EA 2498, Facult\u00e9 de Pharmacie - Universit\u00e9 Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France"},{"name":"Service de Biochimie, H\u00f4tel-Dieu, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Moinard","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie de la Nutrition, EA 2498, Facult\u00e9 de Pharmacie - Universit\u00e9 Paris Descartes, 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"2021120122443228300_B1","article-title":"Arginine in mammals","volume-title":"Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition","author":"Wu","year":"2004"},{"key":"2021120122443228300_B2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ghir.2004.12.004","article-title":"Growth hormone responses to varying doses of oral arginine","volume":"15","author":"Collier","year":"2005","journal-title":"Growth Horm. 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