{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562604,"version":"4.1.0"},"reference-count":52,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:p>Liver cirrhosis is characterized by increased IHR (intrahepatic resistance) and lipid peroxidation, and decreased antioxidative defence. The present study investigates the effects of administration for 1 month of the antioxidant UDCA (ursodeoxycholic acid) in BDL (bile-duct-ligated) cirrhotic rats. Splanchnic haemodynamics, IHR, hepatic levels of TBARS (thiobarbituric acid-reacting substances), GSH (glutathione), SOD (superoxide dismutase) activity, nitrite, PIIINP (N-terminal propeptide of type\u00a0III procollagen) and collagen deposition, histological examination of liver, mRNA expression of PIIIP-\u03b11 (type III procollagen) and TGF-\u03b21 (transforming growth factor-\u03b21), protein expression of TXS (thromboxane synthase) and iNOS (inducible NO synthase), and TXA2 (thromboxane A2) production in liver perfusates were measured. The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-\u03b11 and TGF-\u03b21, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats. The increased levels of hepatic GSH and SOD activity and decreased levels of TBARS and nitrite were also observed in UDCA-treated BDL rats. In UDCA-treated BDL rats, the reduction in portal pressure resulted from a decrease in IHR, which mostly acted through the suppression of hepatic TXA2 production and lipid peroxidation, and an increase in antioxidative defence, leading to the prevention of hepatic fibrosis.<\/jats:p>","DOI":"10.1042\/cs20080075","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T17:13:00Z","timestamp":1227892380000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chronic administration of ursodeoxycholic acid decreases portal pressure in rats with biliary cirrhosis"],"prefix":"10.1042","volume":"116","author":[{"given":"Ying-Ying","family":"Yang","sequence":"first","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tsau","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Chuan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"},{"name":"Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Yauh","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzung-Yan","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Traditional Chinese Medicine, Chang Gung University, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chih","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"},{"name":"Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"},{"name":"Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-Dong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Yang-Ming University School of Medicine, Taipei 11217, Taiwan"},{"name":"Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2008,11,28]]},"reference":[{"key":"2021120120551015800_B1","first-page":"G618","article-title":"Evolution of portal hypertension and mechanisms involved in its maintenance in a rat model","volume":"248","author":"Sikuler","year":"1985","journal-title":"Am. 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