{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:32:15Z","timestamp":1791189135262,"version":"4.1.0"},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"9","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:p>Fluid shift from the legs to the neck induced by LBPP (lower-body positive pressure) increases UA (upper airway) collapsibility in healthy men. Rostral fluid displacement during recumbency may therefore contribute to the pathogenesis of OSA (obstructive sleep apnoea). There is a higher prevalence of OSA in men than in women. We therefore hypothesized that UA collapsibility increases more in men in response to rostral fluid displacement than in women. UA collapsibility was assessed in healthy, non-obese men and women while awake by determining UA Pcrit (critical closing pressure) during application of different suction pressures to the UA. Subjects were randomized to 5\u00a0min control or LBPP arms after which they crossed-over into the other arm following a 30\u00a0min washout. LBPP was applied by inflating anti-shock trousers wrapped around both legs to 40 mmHg. Pcrit, leg fluid volume and neck circumference were measured at baseline and after 5\u00a0min of both control and LBPP periods. LBPP caused a decrease in leg fluid volume and an increase in neck circumference that did not differ between men and women. However, compared with the control period, LBPP induced a much greater increase in Pcrit in men than in women (7.2\u00b11.8 compared with 2.0\u00b11.5\u00a0cmH2O, P=0.035). We conclude that rostral fluid displacement by LBPP increases UA collapsibility more in healthy, non-obese men than in women. This may be one mechanism contributing to the higher prevalence of OSA in men than in women.<\/jats:p>","DOI":"10.1042\/cs20080321","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T10:33:54Z","timestamp":1226658834000},"page":"713-720","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Difference in upper airway collapsibility during wakefulness between men and women in response to lower-body positive pressure"],"prefix":"10.1042","volume":"116","author":[{"given":"Mao-Chang","family":"Su","sequence":"first","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Liang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimon","family":"Ruttanaumpawan","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Shiota","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Yumino","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Redolfi","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0S.","family":"Haight","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology of the University of Toronto, Toronto, ON, Canada M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Yau","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lam","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u00a0Douglas","family":"Bradley","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, ON, Canada, M5G 2A2"},{"name":"Department of Medicine of Toronto General Hospital of the University Health Network, Toronto, ON, Canada, M5G 2C4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2009,4,2]]},"reference":[{"key":"2021113010081224400_B1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1164\/ajrccm.163.3.9911064","article-title":"Prevalence of sleep-disordered breathing in women: effects of gender","volume":"163","author":"Bixler","year":"2001","journal-title":"Am. 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