{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:12:21Z","timestamp":1791180741318,"version":"4.1.0"},"reference-count":235,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a major causative agent of liver disease, resulting in acute and chronic infections that can lead to fibrosis, cirrhosis and hepatocellular carcinoma. Hepatitis C represents the leading cause of liver transplantation in the United States and Europe. A positive-strand RNA virus of the Flaviviridae family, HCV contains a single-stranded RNA genome of approx. 9600 nucleotides. The genome RNA serves as both mRNA for translation of viral proteins and the template for RNA replication. Cis-acting RNA elements within the genome regulate RNA replication by forming secondary structures that interact with each other and trans-acting factors. Although structural proteins are clearly dispensable for RNA replication, recent evidence points to an important role of several non-structural proteins in particle assembly and release, turning their designation on its head. HCV enters host cells through receptor-mediated endocytosis, and the process requires the co-ordination of multiple cellular receptors and co-receptors. RNA replication takes place at specialized intracellular membrane structures called \u2018membranous webs\u2019 or \u2018membrane-associated foci\u2019, whereas viral assembly probably occurs on lipid droplets and endoplasmic reticulum. Liver inflammation plays a central role in the liver damage seen in hepatitis C, but many HCV proteins also directly contribute to HCV pathogenesis. In the present review, the molecular and cellular aspects of the HCV life cycle and the role of viral proteins in pathological liver conditions caused by HCV infection are described.<\/jats:p>","DOI":"10.1042\/cs20080631","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T14:05:15Z","timestamp":1245074715000},"page":"49-65","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Cellular and molecular biology of HCV infection and hepatitis"],"prefix":"10.1042","volume":"117","author":[{"given":"Hengli","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Gris\u00e9","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2009,6,15]]},"reference":[{"key":"2021113010090372000_B1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM197504102921502","article-title":"Transfusion-associated hepatitis not due to viral hepatitis type\u00a0A or B","volume":"292","author":"Feinstone","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"2021113010090372000_B2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.2523562","article-title":"Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome","volume":"244","author":"Choo","year":"1989","journal-title":"Science"},{"key":"2021113010090372000_B3","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/jvi.70.6.3363-3371.1996","article-title":"Identification of a highly conserved sequence element at the 3\u2032 terminus of hepatitis C virus genome RNA","volume":"70","author":"Kolykhalov","year":"1996","journal-title":"J. Virol."},{"key":"2021113010090372000_B4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.277.5325.570","article-title":"Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA","volume":"277","author":"Kolykhalov","year":"1997","journal-title":"Science"},{"key":"2021113010090372000_B5","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1073\/pnas.94.16.8738","article-title":"Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee","volume":"94","author":"Yanagi","year":"1997","journal-title":"Proc. Natl. Acad. Sci. 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Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/13305","article-title":"Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site","volume":"6","author":"Lesburg","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"2021113010090372000_B11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.285.5424.110","article-title":"Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line","volume":"285","author":"Lohmann","year":"1999","journal-title":"Science"},{"key":"2021113010090372000_B12","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.290.5498.1972","article-title":"Efficient initiation of HCV RNA replication in cell culture","volume":"290","author":"Blight","year":"2000","journal-title":"Science"},{"key":"2021113010090372000_B13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1268","article-title":"Production of infectious hepatitis C virus in tissue culture from a cloned viral genome","volume":"11","author":"Wakita","year":"2005","journal-title":"Nat. Med."},{"key":"2021113010090372000_B14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","article-title":"Complete replication of hepatitis C virus in cell culture","volume":"309","author":"Lindenbach","year":"2005","journal-title":"Science"},{"key":"2021113010090372000_B15","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1073\/pnas.0503596102","article-title":"Robust hepatitis C virus infection in vitro","volume":"102","author":"Zhong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B16","doi-asserted-by":"crossref","first-page":"13963","DOI":"10.1128\/JVI.79.22.13963-13973.2005","article-title":"Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells","volume":"79","author":"Cai","year":"2005","journal-title":"J. Virol."},{"key":"2021113010090372000_B17","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1073\/pnas.0510727103","article-title":"Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells","volume":"103","author":"Yi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B18","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1073\/pnas.0504877103","article-title":"Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras","volume":"103","author":"Pietschmann","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B19","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1128\/JVI.80.9.4633-4639.2006","article-title":"Generation of infectious hepatitis C virus in immortalized human hepatocytes","volume":"80","author":"Kanda","year":"2006","journal-title":"J. Virol."},{"key":"2021113010090372000_B20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.22673","article-title":"Development and characterization of hepatitis C virus genotype 1\u20137 cell culture systems: Role of CD81 and scavenger receptor class B type\u00a0I and effect of antiviral drugs","volume":"49","author":"Gottwein","year":"2009","journal-title":"Hepatology"},{"key":"2021113010090372000_B21","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.20819","article-title":"Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes","volume":"42","author":"Simmonds","year":"2005","journal-title":"Hepatology"},{"key":"2021113010090372000_B22","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/jvi.67.6.3338-3344.1993","article-title":"Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism","volume":"67","author":"Wang","year":"1993","journal-title":"J. Virol."},{"key":"2021113010090372000_B23","doi-asserted-by":"crossref","first-page":"12047","DOI":"10.1128\/JVI.75.24.12047-12057.2001","article-title":"Sequences in the 5\u2032 nontranslated region of hepatitis C virus required for RNA replication","volume":"75","author":"Friebe","year":"2001","journal-title":"J. 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Virol."},{"key":"2021113010090372000_B28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nm.1902","article-title":"Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy","volume":"15","author":"Sarasin-Filipowicz","year":"2009","journal-title":"Nat. Med."},{"key":"2021113010090372000_B29","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1128\/JVI.76.11.5326-5338.2002","article-title":"Genetic analysis of sequences in the 3\u2032 nontranslated region of hepatitis C virus that are important for RNA replication","volume":"76","author":"Friebe","year":"2002","journal-title":"J. Virol."},{"key":"2021113010090372000_B30","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1128\/JVI.77.6.3557-3568.2003","article-title":"3\u2032 nontranslated RNA signals required for replication of hepatitis C virus RNA","volume":"77","author":"Yi","year":"2003","journal-title":"J. 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Virol."},{"key":"2021113010090372000_B35","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1099\/vir.0.80141-0","article-title":"Detailed mapping of RNA secondary structures in core and NS5B-encoding region sequences of hepatitis C virus by RNase cleavage and novel bioinformatic prediction methods","volume":"85","author":"Tuplin","year":"2004","journal-title":"J. Gen. Virol."},{"key":"2021113010090372000_B36","doi-asserted-by":"crossref","first-page":"10865","DOI":"10.1128\/JVI.78.20.10865-10877.2004","article-title":"cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome","volume":"78","author":"Lee","year":"2004","journal-title":"J. Virol."},{"key":"2021113010090372000_B37","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1128\/JVI.78.3.1352-1366.2004","article-title":"A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication","volume":"78","author":"You","year":"2004","journal-title":"J. Virol."},{"key":"2021113010090372000_B38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1128\/JVI.79.1.380-392.2005","article-title":"Kissing-loop interaction in the 3\u2032 end of the hepatitis C virus genome essential for RNA replication","volume":"79","author":"Friebe","year":"2005","journal-title":"J. Virol."},{"key":"2021113010090372000_B39","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1128\/JVI.02326-07","article-title":"A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B","volume":"82","author":"Diviney","year":"2008","journal-title":"J. Virol."},{"key":"2021113010090372000_B40","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1128\/JVI.01640-08","article-title":"Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication","volume":"82","author":"Vassilaki","year":"2008","journal-title":"J. Virol."},{"key":"2021113010090372000_B41","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1073\/pnas.88.13.5547","article-title":"Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis","volume":"88","author":"Hijikata","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B42","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1128\/jvi.68.8.5063-5073.1994","article-title":"Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini","volume":"68","author":"Lin","year":"1994","journal-title":"J. Virol."},{"key":"2021113010090372000_B43","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1093\/emboj\/cdf414","article-title":"Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets","volume":"21","author":"McLauchlan","year":"2002","journal-title":"EMBO J."},{"key":"2021113010090372000_B44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ncb1631","article-title":"The lipid droplet is an important organelle for hepatitis C virus production","volume":"9","author":"Miyanari","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2021113010090372000_B45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1099\/vir.0.81664-0","article-title":"Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly","volume":"87","author":"Ait-Goughoulte","year":"2006","journal-title":"J. Gen. Virol."},{"key":"2021113010090372000_B46","doi-asserted-by":"crossref","first-page":"16850","DOI":"10.1074\/jbc.M802273200","article-title":"Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production","volume":"283","author":"Targett-Adams","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113010090372000_B47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2005-864786","article-title":"The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein\/F-protein, the double-frameshift protein, and others","volume":"25","author":"Branch","year":"2005","journal-title":"Semin. Liver Dis."},{"key":"2021113010090372000_B48","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1093\/emboj\/20.14.3840","article-title":"Synthesis of a novel hepatitis C virus protein by ribosomal frameshift","volume":"20","author":"Xu","year":"2001","journal-title":"EMBO J."},{"key":"2021113010090372000_B49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/01.aids.0000168971.57681.6e","article-title":"Characterization of humoral and cell-mediated immune responses directed against hepatitis C virus F protein in subjects co-infected with hepatitis C virus and HIV-1","volume":"19","author":"Troesch","year":"2005","journal-title":"AIDS"},{"key":"2021113010090372000_B50","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1073\/pnas.0611267104","article-title":"Evidence for a functional RNA element in the hepatitis C virus core gene","volume":"104","author":"McMullan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B51","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1099\/0022-1317-78-9-2299","article-title":"Characterization of truncated forms of hepatitis C virus glycoproteins","volume":"78","author":"Michalak","year":"1997","journal-title":"J. Gen. Virol."},{"key":"2021113010090372000_B52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/viro.2000.0693","article-title":"The transmembrane domain of the hepatitis C virus E2 glycoprotein is required for correct folding of the E1 glycoprotein and native complex formation","volume":"279","author":"Patel","year":"2001","journal-title":"Virology"},{"key":"2021113010090372000_B53","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/JVI.77.2.1604-1609.2003","article-title":"Recognition of native hepatitis C virus E1E2 heterodimers by a human monoclonal antibody","volume":"77","author":"Cocquerel","year":"2003","journal-title":"J. Virol."},{"key":"2021113010090372000_B54","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.virol.2004.11.034","article-title":"Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells","volume":"332","author":"Brazzoli","year":"2005","journal-title":"Virology"},{"key":"2021113010090372000_B55","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.282.5390.938","article-title":"Binding of hepatitis C virus to CD81","volume":"282","author":"Pileri","year":"1998","journal-title":"Science"},{"key":"2021113010090372000_B56","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1093\/emboj\/cdf529","article-title":"The human scavenger receptor class B type\u00a0I is a novel candidate receptor for the hepatitis C virus","volume":"21","author":"Scarselli","year":"2002","journal-title":"EMBO J."},{"key":"2021113010090372000_B57","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1128\/JVI.76.8.3720-3730.2002","article-title":"Subcellular localization and topology of the p7 polypeptide of hepatitis C virus","volume":"76","author":"Carrere-Kremer","year":"2002","journal-title":"J. Virol."},{"key":"2021113010090372000_B58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0014-5793(02)03851-6","article-title":"The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine","volume":"535","author":"Griffin","year":"2003","journal-title":"FEBS Lett."},{"key":"2021113010090372000_B59","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1073\/pnas.1031527100","article-title":"The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives","volume":"100","author":"Pavlovic","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B60","doi-asserted-by":"crossref","first-page":"11646","DOI":"10.1073\/pnas.1834545100","article-title":"The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences","volume":"100","author":"Sakai","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B61","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1128\/JVI.00690-07","article-title":"Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus","volume":"81","author":"Jones","year":"2007","journal-title":"J. Virol."},{"key":"2021113010090372000_B62","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1371\/journal.ppat.0030103","article-title":"Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions","volume":"3","author":"Steinmann","year":"2007","journal-title":"PLoS Pathog."},{"key":"2021113010090372000_B63","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1128\/jvi.69.12.7461-7471.1995","article-title":"The NS2 protein of hepatitis C virus is a transmembrane polypeptide","volume":"69","author":"Santolini","year":"1995","journal-title":"J. Virol."},{"key":"2021113010090372000_B64","doi-asserted-by":"crossref","first-page":"10583","DOI":"10.1073\/pnas.90.22.10583","article-title":"A second hepatitis C virus-encoded proteinase","volume":"90","author":"Grakoui","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010090372000_B65","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1128\/jvi.67.8.4665-4675.1993","article-title":"Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus","volume":"67","author":"Hijikata","year":"1993","journal-title":"J. Virol."},{"key":"2021113010090372000_B66","doi-asserted-by":"crossref","first-page":"28546","DOI":"10.1074\/jbc.M803981200","article-title":"Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly","volume":"283","author":"Jirasko","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113010090372000_B67","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nature04975","article-title":"Structure of the catalytic domain of the hepatitis C virus NS2-NS3 protease","volume":"442","author":"Lorenz","year":"2006","journal-title":"Nature"},{"key":"2021113010090372000_B68","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1128\/JVI.74.4.2046-2051.2000","article-title":"Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3\u2032 nontranslated region are essential for virus replication in vivo","volume":"74","author":"Kolykhalov","year":"2000","journal-title":"J. Virol."},{"key":"2021113010090372000_B69","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1128\/JVI.80.1.404-411.2006","article-title":"Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase","volume":"80","author":"Lam","year":"2006","journal-title":"J. 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