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This hypothesis is supported by recent results demonstrating that expression of the intercellular adhesion molecule E-cadherin, deregulation of which is associated with increased cell motility and invasive potential in cancer, is under epigenetic control in trophoblast cell lines. Further elucidation of the epigenetic pathways shared by trophoblasts and malignant cells is likely to lead to the identification of common diagnostic approaches for the early identification both of cancer and pathological pregnancies involving aberrant trophoblast invasion.<\/jats:p>","DOI":"10.1042\/cs20090503","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T11:12:16Z","timestamp":1263294736000},"page":"451-457","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Regulation of invasive growth: similar epigenetic mechanisms underpin tumour progression and implantation in human pregnancy"],"prefix":"10.1042","volume":"118","author":[{"given":"Jo\u00a0K.","family":"Perry","sequence":"first","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger\u00a0J.","family":"Lins","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland, New Zealand"},{"name":"The National Research Centre for Growth and Development, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0E.","family":"Lobie","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland, New Zealand"},{"name":"The Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray\u00a0D.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"The Liggins Institute, The University of Auckland, Auckland, New Zealand"},{"name":"The National Research Centre for Growth and Development, The University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"key":"2021113010105134600_B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/humupd\/dml048","article-title":"Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts","volume":"13","author":"Ferretti","year":"2007","journal-title":"Hum. 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