{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T02:47:10Z","timestamp":1782614830220,"version":"3.54.5"},"reference-count":49,"publisher":"Portland Press Ltd.","issue":"8","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":3137,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:p>ACE (angiotensin-converting enzyme) 2 is expressed in the heart and kidney and metabolizes Ang (angiotensin) II to Ang-(1\u20137) a peptide that acts via the Ang-(1\u20137) or mas receptor. The aim of the present study was to assess the effect of Ang-(1\u20137) on blood pressure and cardiac remodelling in a rat model of renal mass ablation. Male SD (Sprague\u2013Dawley) rats underwent STNx (subtotal nephrectomy) and were treated for 10\u00a0days with vehicle, the ACE inhibitor ramipril (oral 1\u00a0mg\u00b7kg\u22121 of body weight\u00b7day\u22121) or Ang-(1\u20137) (subcutaneous 24 \u03bcg\u00b7kg\u22121 of body weight\u00b7h\u22121) (all n = 15 per group). A control group (n = 10) of sham-operated rats were also studied. STNx rats were hypertensive (P&amp;lt;0.01) with renal impairment (P&amp;lt;0.001), cardiac hypertrophy (P&amp;lt;0.001) and fibrosis (P&amp;lt;0.05), and increased cardiac ACE (P&amp;lt;0.001) and ACE2 activity (P&amp;lt;0.05). Ramipril reduced blood pressure (P&amp;lt;0.01), improved cardiac hypertrophy (P&amp;lt;0.001) and inhibited cardiac ACE (P&amp;lt;0.001). By contrast, Ang-(1\u20137) infusion in STNx was associated with further increases in blood pressure (P&amp;lt;0.05), cardiac hypertrophy (P&amp;lt;0.05) and fibrosis (P&amp;lt;0.01). Ang-(1\u20137) infusion also increased cardiac ACE activity (P&amp;lt;0.001) and reduced cardiac ACE2 activity (P&amp;lt;0.05) compared with STNx-vehicle rats. Our results add to the increasing evidence that Ang-(1\u20137) may have deleterious cardiovascular effects in kidney failure and highlight the need for further in vivo studies of the ACE2\/Ang-(1\u20137)\/mas receptor axis in kidney disease.<\/jats:p>","DOI":"10.1042\/cs20100280","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T15:53:17Z","timestamp":1290181997000},"page":"335-345","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Angiotensin-(1\u20137) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy"],"prefix":"10.1042","volume":"120","author":[{"given":"Elena","family":"Velkoska","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael\u00a0G.","family":"Dean","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Burchill","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise\u00a0M.","family":"Burrell","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria 3081, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"2021113011061454300_B1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ncpneph1015","article-title":"The importance of the intrarenal renin-angiotensin system","volume":"5","author":"Velez","year":"2009","journal-title":"Nat. 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