{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:22:56Z","timestamp":1761862976027},"reference-count":57,"publisher":"Portland Press Ltd.","issue":"12","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>Preprandial aerobic exercise lowers postprandial lipaemia (a risk factor for coronary heart disease); however, the mechanisms responsible are still not clear. The present study investigated whether blood flow to skeletal muscle and\/or the liver was increased in the postprandial period after exercise, relative to a control trial, and whether this resulted from increased cardiac output or redistribution of flow. Eight overweight inactive males, aged 49.4\u00b110.5\u00a0years (mean\u00b1S.D.), acted as their own controls in a counterbalanced design, either walking briskly for 90\u00a0min at 60% V\u0307O2max (maximal oxygen uptake), or resting in the lab, on the evening of day 1. The following morning, a fasting blood sample was collected, participants consumed a high-fat breakfast, and further venous blood samples were drawn hourly for 6\u00a0h. Immediately after blood sampling, Doppler ultrasound was used to measure cardiac output and blood flow through both the femoral artery of one leg and the hepatic portal vein, with the ultrasonographer blinded to trial order. The total postprandial triacylglycerol response was 22% lower after exercise (P=0.001). Blood flow through the femoral artery and the hepatic portal vein was increased by 19% (P&amp;lt;0.001) and 16% (P=0.033), respectively, during the 6-h postprandial period following exercise; however, postprandial cardiac output did not differ between trials (P=0.065). Redistribution of blood flow, to both exercised skeletal muscle and the liver, may therefore play a role in reducing the plasma triacylglycerol response to a high-fat meal on the day after an exercise bout.<\/jats:p>","DOI":"10.1042\/cs20100460","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T14:34:10Z","timestamp":1297953250000},"page":"537-548","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Is the beneficial effect of prior exercise on postprandial lipaemia partly due to redistribution of blood flow?"],"prefix":"10.1042","volume":"120","author":[{"given":"Nicholas\u00a0M.","family":"Hurren","sequence":"first","affiliation":[{"name":"School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George\u00a0M.","family":"Balanos","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew\u00a0K.","family":"Blannin","sequence":"additional","affiliation":[{"name":"School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2011,3,9]]},"reference":[{"key":"2021113010164107600_B1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.60.3.473","article-title":"Atherogenesis: a postprandial phenomenon","volume":"60","author":"Zilversmit","year":"1979","journal-title":"Circulation"},{"key":"2021113010164107600_B2","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/01.ATV.12.11.1336","article-title":"Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state","volume":"12","author":"Patsch","year":"1992","journal-title":"Arterioscler. Thromb."},{"key":"2021113010164107600_B3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0021-9150(98)00184-1","article-title":"Magnitude of alimentary lipemia is related to intima\u2013media thickness of the common carotid artery in middle-aged men","volume":"141","author":"Karpe","year":"1998","journal-title":"Atherosclerosis"},{"key":"2021113010164107600_B4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.298.3.299","article-title":"Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women","volume":"298","author":"Nordestgaard","year":"2007","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"2021113010164107600_B5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jama.298.3.309","article-title":"Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women","volume":"298","author":"Bansal","year":"2007","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"2021113010164107600_B6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0955-2863(02)00275-9","article-title":"Exercise and postprandial lipid metabolism: an update on potential mechanisms and interactions with high-carbohydrate diets","volume":"14","author":"Gill","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"2021113010164107600_B7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/meta.2003.50071","article-title":"Effects of prior exercise on postprandial lipemia: a quantitative review","volume":"52","author":"Petitt","year":"2003","journal-title":"Metab. Clin. Exp."},{"key":"2021113010164107600_B8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0026-0495(84)90147-1","article-title":"Acute increase in lipoprotein lipase following prolonged exercise","volume":"33","author":"Kantor","year":"1984","journal-title":"Metab. Clin. Exp."},{"key":"2021113010164107600_B9","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1001\/jama.1986.03380180114030","article-title":"Prolonged exercise augments plasma triglyceride clearance","volume":"256","author":"Sady","year":"1986","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"2021113010164107600_B10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/jappl.1998.85.3.1169","article-title":"Effects of four different single exercise sessions on lipids, lipoproteins, and lipoprotein lipase","volume":"85","author":"Ferguson","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1053\/meta.2001.24199","article-title":"Moderate exercise, postprandial lipaemia, and skeletal muscle lipoprotein lipase activity","volume":"50","author":"Herd","year":"2001","journal-title":"Metab. Clin. Exp."},{"key":"2021113010164107600_B12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00421-002-0788-9","article-title":"Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states","volume":"89","author":"Gill","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"2021113010164107600_B13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1152\/japplphysiol.00243.2003","article-title":"Effects of low and moderate exercise intensity on postprandial lipaemia and postheparin plasma lipoprotein lipase activity in physically active men","volume":"96","author":"Katsanos","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B14","doi-asserted-by":"crossref","first-page":"E1020","DOI":"10.1152\/ajpendo.2000.279.5.E1020","article-title":"Prior exercise and postprandial substrate extraction across the human leg. Am","volume":"279","author":"Malkova","year":"2000","journal-title":"J. Physiol. Endocrinol. Metab."},{"key":"2021113010164107600_B15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1042\/CS20000258","article-title":"Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity","volume":"100","author":"Gill","year":"2001","journal-title":"Clin. Sci."},{"key":"2021113010164107600_B16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ejlt.200300906","article-title":"Exercise and postprandial lipid metabolism \u2013 an analysis of the current evidence","volume":"106","author":"Gill","year":"2004","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"2021113010164107600_B17","doi-asserted-by":"crossref","first-page":"E355","DOI":"10.1152\/ajpendo.00259.2005","article-title":"Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men","volume":"290","author":"Magkos","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113010164107600_B18","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.metabol.2007.03.012","article-title":"A single bout of brisk walking increases basal very low-density lipoprotein triacylglycerol clearance in young men","volume":"56","author":"Tsekouras","year":"2007","journal-title":"Metab. Clin. Exp."},{"key":"2021113010164107600_B19","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/sj.ejcn.1601968","article-title":"Effect of prior exercise on lipemia after a meal of moderate fat content","volume":"58","author":"Kolifa","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"2021113010164107600_B20","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1152\/japplphysiol.01211.2004","article-title":"Is postexercise hypotension related to excess postexercise oxygen consumption through changes in leg blood flow?","volume":"98","author":"Williams","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0735-1097(00)01054-8","article-title":"Age-predicted maximal heart rate revisited","volume":"37","author":"Tanaka","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010164107600_B22","article-title":"Nutritional aspects of cardiovascular disease","volume-title":"Report of the Cardiovascular Review Group of the Committee on Medical Aspects of Food Policy","author":"Department of Health","year":"1994"},{"key":"2021113010164107600_B23","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1055\/s-2004-830512","article-title":"Measurement of substrate oxidation during exercise by means of gas exchange measurements","volume":"26","author":"Jeukendrup","year":"2005","journal-title":"Int. J. Sports. Med."},{"key":"2021113010164107600_B24","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.2337\/diacare.21.12.2191","article-title":"Correct homeostasis model assessment (HOMA) evaluation uses the computer program","volume":"21","author":"Levy","year":"1998","journal-title":"Diabetes Care"},{"key":"2021113010164107600_B25"},{"key":"2021113010164107600_B26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychological bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med. Sci. Sports Exercise"},{"key":"2021113010164107600_B27","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1172\/JCI105043","article-title":"Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man","volume":"43","author":"Rowell","year":"1964","journal-title":"J. Clin. Invest."},{"key":"2021113010164107600_B28","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1148\/radiology.155.3.3890004","article-title":"Portal venous hemodynamics in chronic liver disease: effects of posture change and exercise","volume":"155","author":"Ohnishi","year":"1985","journal-title":"Radiology"},{"key":"2021113010164107600_B29","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1097\/00005768-200109000-00017","article-title":"Effect of exercise on portal vein blood flow in man","volume":"33","author":"Rehrer","year":"2001","journal-title":"Med. Sci. Sports Exercise"},{"key":"2021113010164107600_B30","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0041-1345(03)00467-6","article-title":"Changes in portal blood flow following acute exercise in liver transplant patients","volume":"35","author":"Ersoz","year":"2003","journal-title":"Transplant. Proc."},{"key":"2021113010164107600_B31","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/hep.1840090604","article-title":"Effect of meal on portal hemodynamics in healthy humans and in patients with chronic liver disease","volume":"9","author":"Gaiani","year":"1989","journal-title":"Hepatology"},{"key":"2021113010164107600_B32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/hep.1840130417","article-title":"Evaluation of postprandial hyperemia in superior mesenteric artery and portal vein in healthy and cirrhotic humans: an operator-blind echo-Doppler study","volume":"13","author":"Sabb\u00e1","year":"1991","journal-title":"Hepatology"},{"key":"2021113010164107600_B33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1148\/radiology.201.3.8939220","article-title":"Postprandial splanchnic hemodynamic response in patients with cirrhosis of the liver: evaluation of \u2018triple-vessel\u2019 duplex US","volume":"201","author":"Iwao","year":"1996","journal-title":"Radiology"},{"key":"2021113010164107600_B34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0168-8278(98)80287-0","article-title":"The postprandial portal flow is related to the severity of portal hypertension and liver cirrhosis","volume":"28","author":"Ludwig","year":"1998","journal-title":"J. Hepatol."},{"key":"2021113010164107600_B35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/00042737-199805000-00007","article-title":"Direct measurement of post-prandial portal haemodynamics in cirrhotic patients with a transjugular intrahepatic portosystemic stent-shunt","volume":"10","author":"Stanley","year":"1998","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"2021113010164107600_B36","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/0016-5085(90)91097-P","article-title":"Observer variability in echo-Doppler measurements of portal flow in cirrhotic patients and normal volunteers","volume":"98","author":"Sabb\u00e1","year":"1990","journal-title":"Gastroenterology"},{"key":"2021113010164107600_B37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1440-1746.1996.tb00008.x","article-title":"Echo-Doppler measurements of portal vein and superior mesenteric artery blood flow in humans: inter- and intra-observer short-term reproducibility","volume":"11","author":"Iwao","year":"1996","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2021113010164107600_B38","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1148\/radiology.207.3.9609894","article-title":"Doppler sonography of the portal vein and hepatic artery: measurement of a prandial effect in healthy subjects","volume":"207","author":"Fisher","year":"1998","journal-title":"Radiology"},{"key":"2021113010164107600_B39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0168-8278(97)80045-1","article-title":"Variability of splanchnic blood flow measurements using MR velocity mapping under fasting and post-prandial conditions \u2013 comparisons with echo-Doppler","volume":"26","author":"Lycklama\u00a0\u00e0\u00a0Nijeholt","year":"1997","journal-title":"J. Hepatol."},{"key":"2021113010164107600_B40","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1113\/jphysiol.2007.135673","article-title":"Skeletal muscle vasodilatation at the onset of exercise","volume":"583","author":"Clifford","year":"2007","journal-title":"J. Physiol."},{"key":"2021113010164107600_B41","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1152\/jappl.1987.62.2.606","article-title":"Maximal vascular leg conductance in trained and untrained men","volume":"62","author":"Snell","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B42","first-page":"E248","article-title":"Effect of physical exercise on sensitivity and responsiveness to insulin in humans","volume":"254","author":"Mikines","year":"1988","journal-title":"Am. J. Physiol."},{"key":"2021113010164107600_B43","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJM199610313351804","article-title":"Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects","volume":"335","author":"Perseghin","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"2021113010164107600_B44","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1172\/JCI114644","article-title":"Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance","volume":"85","author":"Laakso","year":"1990","journal-title":"J. Clin. Invest."},{"key":"2021113010164107600_B45","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/01.CIR.97.21.2146","article-title":"Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension","volume":"97","author":"Laine","year":"1998","journal-title":"Circulation"},{"key":"2021113010164107600_B46","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1210\/jcem-70-6-1525","article-title":"Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity","volume":"70","author":"Baron","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113010164107600_B47","doi-asserted-by":"crossref","first-page":"E1191","DOI":"10.1152\/ajpendo.00497.2005","article-title":"Mixed meal and light exercise each recruit muscle capillaries in healthy humans","volume":"290","author":"Vincent","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021113010164107600_B48","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/ajcn\/88.1.51","article-title":"Endothelial function after high-sugar food ingestion improves with endurance exercise performed on the previous day","volume":"88","author":"Weiss","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"2021113010164107600_B49","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI118871","article-title":"Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells","volume":"98","author":"Zeng","year":"1996","journal-title":"J. Clin. Invest."},{"key":"2021113010164107600_B50","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jacc.2008.09.033","article-title":"Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise","volume":"53","author":"Tyldum","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010164107600_B51","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1152\/japplphysiol.00821.2006","article-title":"Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training","volume":"102","author":"Wadley","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B52","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2337\/db05-1574","article-title":"Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase","volume":"55","author":"Wang","year":"2006","journal-title":"Diabetes"},{"key":"2021113010164107600_B53","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1161\/CIRCRESAHA.108.189316","article-title":"Contribution of insulin and Akt1 signalling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure","volume":"104","author":"Symons","year":"2009","journal-title":"Circ. Res."},{"key":"2021113010164107600_B54","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1152\/japplphysiol.01329.2007","article-title":"Last word on Point:Counterpoint: there is\/is not capillary recruitment in active skeletal muscle during exercise","volume":"104","author":"Poole","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"2021113010164107600_B55","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1365-2125.2000.00278.x","article-title":"Capillaroscopy and the measurement of capillary pressure","volume":"50","author":"Shore","year":"2000","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2021113010164107600_B56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2337\/diabetes.51.1.42","article-title":"Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow","volume":"51","author":"Vincent","year":"2002","journal-title":"Diabetes"},{"key":"2021113010164107600_B57","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2337\/diabetes.53.2.447","article-title":"Insulin sensitivity of muscle capillary recruitment in vivo","volume":"53","author":"Zhang","year":"2004","journal-title":"Diabetes"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/120\/12\/537\/441682\/cs1200537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/120\/12\/537\/441682\/cs1200537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T10:32:49Z","timestamp":1638268369000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/120\/12\/537\/68822\/Is-the-beneficial-effect-of-prior-exercise-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,9]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20100460","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,9]]}}}