{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:32:11Z","timestamp":1790728331796,"version":"4.1.0"},"reference-count":208,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":2680,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:p>Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2\u20135% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu.<\/jats:p>","DOI":"10.1042\/cs20110627","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T23:42:09Z","timestamp":1332546129000},"page":"53-72","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies"],"prefix":"10.1042","volume":"123","author":[{"given":"Esther\u00a0F.","family":"Davis","sequence":"first","affiliation":[{"name":"Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Newton","sequence":"additional","affiliation":[{"name":"Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."},{"name":"Wellcome Trust Centre for Human Genetics, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam\u00a0J.","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merzaka","family":"Lazdam","sequence":"additional","affiliation":[{"name":"Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda\u00a0A.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosios","family":"Kyriakou","sequence":"additional","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Leeson","sequence":"additional","affiliation":[{"name":"Oxford Cardiovascular Clinical Research Facility, Department of Cardiovascular Medicine, University of Oxford, Oxford, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,3,23]]},"reference":[{"key":"2021113010231368500_B1","doi-asserted-by":"crossref","first-page":"45.e41","DOI":"10.1016\/j.ajog.2007.06.067","article-title":"Folic acid supplementation in early second trimester and the risk of preeclampsia","volume":"198","author":"Wen","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"2021113010231368500_B3","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/bmj.39335.385301.BE","article-title":"Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis","volume":"335","author":"Bellamy","year":"2007","journal-title":"BMJ"},{"key":"2021113010231368500_B4","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ahj.2008.06.042","article-title":"Cardiovascular sequelae of preeclampsia\/eclampsia: a systematic review and meta-analyses","volume":"156","author":"McDonald","year":"2008","journal-title":"Am. Heart J."},{"key":"2021113010231368500_B5","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1097\/HJH.0b013e328331b8c6","article-title":"Preeclampsia and increased blood pressure in the offspring: meta-analysis and critical review of the evidence","volume":"27","author":"Ferreira","year":"2009","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/STROKEAHA.108.538025","article-title":"Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki Birth Cohort Study","volume":"40","author":"Kajantie","year":"2009","journal-title":"Stroke"},{"key":"2021113010231368500_B7","first-page":"529","article-title":"Intrauterine exposure to preeclampsia and adolescent blood pressure, body size, and age at menarche in female offspring","volume":"101","author":"Vatten","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"2021113010231368500_B8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/adc.2008.150870","article-title":"Pubertal anthropometry in sons and daughters of women with preeclamptic or normotensive pregnancies","volume":"94","author":"Ogland","year":"2009","journal-title":"Arch. Dis. Child."},{"key":"2021113010231368500_B9","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3109\/00016349.2010.519378","article-title":"Dietary intake and physical activity in women and offspring after pregnancies complicated by preeclampsia or diabetes mellitus","volume":"89","author":"Kvehaugen","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2021113010231368500_B10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/CIRCULATIONAHA.110.936674","article-title":"Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal Study of Parents and Children","volume":"122","author":"Geelhoed","year":"2010","journal-title":"Circulation"},{"key":"2021113010231368500_B11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/CIRCULATIONAHA.110.941203","article-title":"Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia","volume":"122","author":"Jayet","year":"2010","journal-title":"Circulation"},{"key":"2021113010231368500_B12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/HYPERTENSIONAHA.110.150235","article-title":"Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?","volume":"56","author":"Lazdam","year":"2010","journal-title":"Hypertension"},{"key":"2021113010231368500_B13","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1471-0528.1991.tb15339.x","article-title":"Pre-eclampsia and offspring's blood pressure, cognitive ability and physical development at 17-years-of-age","volume":"98","author":"Seidman","year":"1991","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"2021113010231368500_B14","first-page":"1217","article-title":"Blood pressure, serum lipids, fasting insulin, and adrenal hormones in 12-year-old children born with maternal preeclampsia. J. Clin. Endocrinol","volume":"88","author":"Tenhola","year":"2003","journal-title":"Metab."},{"key":"2021113010231368500_B15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/eurheartj\/ehr300","article-title":"Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children","volume":"33","author":"Lawlor","year":"2012","journal-title":"Eur. Heart J."},{"key":"2021113010231368500_B16","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1097\/HJH.0b013e328330052a","article-title":"Blood pressure in early adolescence in the offspring of preeclamptic and normotensive pregnancies","volume":"27","author":"\u00d8gl\u00e6nd","year":"2009","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B17","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1542\/peds.2007-0833","article-title":"Pediatric prevention of atherosclerosis: targeting early variation in vascular biology","volume":"119","author":"Leeson","year":"2007","journal-title":"Pediatrics"},{"key":"2021113010231368500_B18","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2011-3093","article-title":"Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review","author":"Davis","year":"2012","journal-title":"Pediatrics"},{"key":"2021113010231368500_B19","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1161\/CIRCULATIONAHA.107.730366","article-title":"Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis","volume":"117","author":"Chen","year":"2008","journal-title":"Circulation"},{"key":"2021113010231368500_B20","volume-title":"Hypertension (Update)","author":"NICE","year":"2011"},{"key":"2021113010231368500_B21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bpobgyn.2011.02.007","article-title":"The genetics of pre-eclampsia and other hypertensive disorders of pregnancy","volume":"25","author":"Williams","year":"2011","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"2021113010231368500_B22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/BJ20091861","article-title":"Mechanisms involved in the developmental programming of adulthood disease","volume":"427","author":"Warner","year":"2010","journal-title":"Biochem. J."},{"key":"2021113010231368500_B23","first-page":"38","article-title":"Programming by early nutrition in man","volume":"156","author":"Lucas","year":"1991","journal-title":"Ciba Found. Symp."},{"key":"2021113010231368500_B24","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ajh.2008.241","article-title":"Being born too small, too early, or both: does it matter for risk of hypertension in the elderly?","volume":"21","author":"Bonamy","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"2021113010231368500_B25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/bmj.311.6998.171","article-title":"Fetal origins of coronary heart disease","volume":"311","author":"Barker","year":"1995","journal-title":"Br. Med. J."},{"key":"2021113010231368500_B26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/bmj.301.6746.259","article-title":"Fetal and placental size and risk of hypertension in adult life","volume":"301","author":"Barker","year":"1990","journal-title":"Br. Med. J."},{"key":"2021113010231368500_B27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF00399095","article-title":"Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth","volume":"36","author":"Barker","year":"1993","journal-title":"Diabetologia"},{"key":"2021113010231368500_B28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1053\/j.semperi.2010.02.009","article-title":"Preterm birth: an emerging risk factor for adult hypertension?","volume":"34","author":"Norman","year":"2010","journal-title":"Semin. Perinatol."},{"key":"2021113010231368500_B29","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/00004872-200018070-00002","article-title":"The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature","volume":"18","author":"Huxley","year":"2000","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B30","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/10641950903572282","article-title":"Are early and late preeclampsia distinct subclasses of the disease-what does the placenta reveal?","volume":"29","author":"van der Merwe","year":"2010","journal-title":"Hypertens. Pregnancy"},{"key":"2021113010231368500_B31","first-page":"124","article-title":"Endothelial vasodilatation in newborns is related to body size and maternal hypertension","volume":"31","author":"Touwslager","year":"2011","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B32","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0140-6736(01)06276-6","article-title":"Preterm birth, vascular function, and risk factors for atherosclerosis","volume":"358","author":"Singhal","year":"2001","journal-title":"Lancet"},{"key":"2021113010231368500_B33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/ki.2009.284","article-title":"The biology of preeclampsia","volume":"76","author":"Kanasaki","year":"2009","journal-title":"Kidney Int."},{"key":"2021113010231368500_B34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0897.2010.00831.x","article-title":"Immunology of pre-eclampsia","volume":"63","author":"Redman","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"2021113010231368500_B35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2008.11.021","article-title":"Placental stress and pre-eclampsia: a revised view","volume":"30","author":"Redman","year":"2009","journal-title":"Placenta"},{"key":"2021113010231368500_B36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.atherosclerosis.2004.01.038","article-title":"Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?","volume":"175","author":"Rodie","year":"2004","journal-title":"Atherosclerosis"},{"key":"2021113010231368500_B37","first-page":"69","article-title":"Endothelial dysfunction in pre-eclampsia","volume":"58","author":"Poston","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"2021113010231368500_B38","doi-asserted-by":"crossref","first-page":"123717","DOI":"10.1155\/2011\/123717","article-title":"Disrupted balance of angiogenic and antiangiogenic signalings in preeclampsia","volume":"2011","author":"Furuya","year":"2011","journal-title":"J. Pregnancy"},{"key":"2021113010231368500_B39","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1600-0897.2010.00929.x","article-title":"Animal models of pre-eclampsia","volume":"65","author":"Sunderland","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"2021113010231368500_B40","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.placenta.2011.03.010","article-title":"Animal models of preeclampsia; uses and limitations","volume":"32","author":"McCarthy","year":"2011","journal-title":"Placenta"},{"key":"2021113010231368500_B41","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0026-0495(99)90225-1","article-title":"Evidence of a state of increased insulin resistance in preeclampsia","volume":"48","author":"Kaaja","year":"1999","journal-title":"Metab. Clin. Exp."},{"key":"2021113010231368500_B42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jri.2009.04.009","article-title":"The link between insulin resistance and preeclampsia: new perspectives","volume":"82","author":"Scioscia","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"2021113010231368500_B43","first-page":"113","article-title":"Animal models for small for gestational age and fetal programming of adult disease","volume":"68","author":"Vuguin","year":"2007","journal-title":"Horm. Res."},{"key":"2021113010231368500_B44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3181\/00379727-43-11091P","article-title":"Rise of blood pressure during ischemia of the gravid uterus","volume":"43","author":"Ogden","year":"1940","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"2021113010231368500_B45","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0002-9378(76)90169-1","article-title":"Production of experimental toxemia in the pregnant rabbit","volume":"124","author":"Abitbol","year":"1976","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B46","first-page":"H297","article-title":"A model for studying chronic reduction in uterine blood flow in pregnant sheep","volume":"242","author":"Clark","year":"1982","journal-title":"Am. J. Physiol."},{"key":"2021113010231368500_B47","first-page":"174","article-title":"Experimental toxemia in the pregnant guinea pig (Cavia porcellus)","volume":"30","author":"Golden","year":"1980","journal-title":"Lab. Anim. Sci."},{"key":"2021113010231368500_B48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0002-9378(77)90296-4","article-title":"Experimental toxemia in the pregnant primate","volume":"128","author":"Cavanagh","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B49","first-page":"537","article-title":"Production of experimental toxemia in the pregnant dog","volume":"48","author":"Abitbol","year":"1976","journal-title":"Obstet. Gynecol."},{"key":"2021113010231368500_B50","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.HYP.37.4.1191","article-title":"Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide","volume":"37","author":"Alexander","year":"2001","journal-title":"Hypertension"},{"key":"2021113010231368500_B51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/HYPERTENSIONAHA.109.132191","article-title":"Plasma-mediated vascular dysfunction in the reduced uterine perfusion pressure model of preeclampsia","volume":"54","author":"Walsh","year":"2009","journal-title":"Hypertension"},{"key":"2021113010231368500_B52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/01.HYP.35.1.367","article-title":"Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat","volume":"35","author":"Crews","year":"2000","journal-title":"Hypertension"},{"key":"2021113010231368500_B53","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/HYPERTENSIONAHA.107.096594","article-title":"Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble Fms-like tyrosine kinase-1 expression","volume":"50","author":"Gilbert","year":"2007","journal-title":"Hypertension"},{"key":"2021113010231368500_B54","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1161\/01.HYP.0000084990.88147.0C","article-title":"Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion","volume":"42","author":"Payne","year":"2003","journal-title":"Hypertension"},{"key":"2021113010231368500_B55","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/1099800408324127","article-title":"Placental insufficiency: programming of leptin secretion, blood pressure, and postnatal growth in two generations of Sprague-Dawley rats","volume":"10","author":"Anderson","year":"2009","journal-title":"Biol. Res. Nurs."},{"key":"2021113010231368500_B56","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1258\/ebm.2010.009357","article-title":"Chronic placental ischemia alters amniotic fluid milieu and results in impaired glucose tolerance, insulin resistance and hyperleptinemia in young rats","volume":"235","author":"Heltemes","year":"2010","journal-title":"Exp. Biol. Med."},{"key":"2021113010231368500_B57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ki.2008.153","article-title":"Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats","volume":"74","author":"Wlodek","year":"2008","journal-title":"Kidney Int."},{"key":"2021113010231368500_B58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.HYP.0000053448.95913.3D","article-title":"Placental insufficiency leads to development of hypertension in growth-restricted offspring","volume":"41","author":"Alexander","year":"2003","journal-title":"Hypertension"},{"key":"2021113010231368500_B59","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1440-1681.2007.04754.x","article-title":"Early renal denervation prevents development of hypertension in growth-restricted offspring","volume":"34","author":"Ojeda","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2021113010231368500_B60","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/HYPERTENSIONAHA.107.091785","article-title":"Estrogen protects against increased blood pressure in postpubertal female growth restricted offspring","volume":"50","author":"Ojeda","year":"2007","journal-title":"Hypertension"},{"key":"2021113010231368500_B61","doi-asserted-by":"crossref","first-page":"R804","DOI":"10.1152\/ajpregu.00725.2006","article-title":"Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring","volume":"293","author":"Grigore","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B62","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.HYP.0000153319.20340.2a","article-title":"Renal denervation abolishes hypertension in low-birth-weight offspring from pregnant rats with reduced uterine perfusion","volume":"45","author":"Alexander","year":"2005","journal-title":"Hypertension"},{"key":"2021113010231368500_B63","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1113\/jphysiol.2010.187849","article-title":"Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring","volume":"588","author":"Mazzuca","year":"2010","journal-title":"J. Physiol."},{"key":"2021113010231368500_B64","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1203\/PDR.0b013e3181761859","article-title":"Increased elastic tissue defect formation in the growth restricted brown Norway rat: a potential link between in utero condition and cardiovascular disease","volume":"64","author":"Pascoe","year":"2008","journal-title":"Pediatr. Res."},{"key":"2021113010231368500_B65","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1113\/jphysiol.2009.170407","article-title":"Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats","volume":"587","author":"Moritz","year":"2009","journal-title":"J. Physiol."},{"key":"2021113010231368500_B66","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/152702903322022785","article-title":"The placenta at high altitude","volume":"4","author":"Zamudio","year":"2003","journal-title":"High Alt. Med. Biol."},{"key":"2021113010231368500_B67","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2005-0078","article-title":"Molecular evidence of placental hypoxia in preeclampsia","volume":"90","author":"Soleymanlou","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021113010231368500_B68","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/HYPERTENSIONAHA.110.163329","article-title":"A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice","volume":"57","author":"Lai","year":"2011","journal-title":"Hypertension"},{"key":"2021113010231368500_B69","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1152\/japplphysiol.01174.2010","article-title":"Flow-mediated vasodilation is impaired in adult rat offspring exposed to prenatal hypoxia","volume":"110","author":"Morton","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"2021113010231368500_B70","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/jphysiol.2005.084889","article-title":"Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring","volume":"565","author":"Williams","year":"2005","journal-title":"J. Physiol."},{"key":"2021113010231368500_B71","doi-asserted-by":"crossref","first-page":"H674","DOI":"10.1152\/ajpheart.00191.2005","article-title":"Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy","volume":"289","author":"Hemmings","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010231368500_B72","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s00424-001-0766-9","article-title":"Long-lasting adverse effects of prenatal hypoxia on developing autonomic nervous system and cardiovascular parameters in rats","volume":"443","author":"Peyronnet","year":"2002","journal-title":"Pfl\u00fcgers Arch."},{"key":"2021113010231368500_B73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2007.04.009","article-title":"Molecular mechanisms of preeclampsia","volume":"75","author":"Mutter","year":"2008","journal-title":"Microvasc. Res."},{"key":"2021113010231368500_B74","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2021113010231368500_B75","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"Ahmad","year":"2004","journal-title":"Circ. Res."},{"key":"2021113010231368500_B76","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2021113010231368500_B77","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.ajog.2006.12.024","article-title":"The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice","volume":"196","author":"Lu","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B78","doi-asserted-by":"crossref","first-page":"418.e1","DOI":"10.1016\/j.ajog.2007.06.064","article-title":"Gender-specific effect of overexpression of sFlt-1 in pregnant mice on fetal programming of blood pressure in the offspring later in life","volume":"197","author":"Lu","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B79","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.59.110106.214058","article-title":"Preeclampsia and angiogenic imbalance","volume":"59","author":"Maynard","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"2021113010231368500_B80","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang","year":"1995","journal-title":"Nature"},{"key":"2021113010231368500_B81","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1067\/mob.2001.118142","article-title":"Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy","volume":"185","author":"Shesely","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B82","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/01.HYP.0000257876.87284.3c","article-title":"Maternal endothelial nitric oxide synthase genotype influences offspring blood pressure and activity in mice","volume":"49","author":"Van Vliet","year":"2007","journal-title":"Hypertension"},{"key":"2021113010231368500_B83","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/HYPERTENSIONAHA.107.099721","article-title":"Aortic diameter, wall stiffness, and wave reflection in systolic hypertension","volume":"51","author":"Mitchell","year":"2008","journal-title":"Hypertension"},{"key":"2021113010231368500_B84","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/aps.2010.123","article-title":"Arterial stiffness: a brief review","volume":"31","author":"Shirwany","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"2021113010231368500_B85","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1161\/ATVBAHA.111.227298","article-title":"Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac function","volume":"31","author":"Lewandowski","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010231368500_B86","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ajog.2004.01.050","article-title":"Cardiovascular and renal disease in the adolescent guinea pig after chronic placental insufficiency","volume":"191","author":"Briscoe","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B87","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000330666","article-title":"Morphological and functional alterations in the aorta of the chronically hypoxic fetal rat","volume":"49","author":"Herrera","year":"2011","journal-title":"J. Vasc. Res."},{"key":"2021113010231368500_B88","doi-asserted-by":"crossref","first-page":"495.e24","DOI":"10.1016\/j.ajog.2010.06.046","article-title":"Partial contributions of developmental hypoxia and undernutrition to prenatal alterations in somatic growth and cardiovascular structure and function","volume":"203","author":"Camm","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B89","doi-asserted-by":"crossref","first-page":"H1321","DOI":"10.1152\/ajpheart.00440.2008","article-title":"Hypoxia during pregnancy in rats leads to early morphological changes of atherosclerosis in adult offspring","volume":"296","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010231368500_B90","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1161\/HYPERTENSIONAHA.109.192639","article-title":"Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association","volume":"54","author":"Urbina","year":"2009","journal-title":"Hypertension"},{"key":"2021113010231368500_B91","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis","volume":"115","author":"Lorenz","year":"2007","journal-title":"Circulation"},{"key":"2021113010231368500_B92","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1515\/jpem.2010.179","article-title":"The relationship between abdominal aortic intima-media thickness and lipid profile in neonates born to mothers with preeclampsia","volume":"23","author":"Akcakus","year":"2010","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"2021113010231368500_B93","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0895-7061(00)01245-0","article-title":"Diastolic dysfunction precedes myocardial hypertrophy in the development of hypertension","volume":"14","author":"Aeschbacher","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"2021113010231368500_B94","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cvr\/cvq363","article-title":"Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia\/reperfusion","volume":"90","author":"Rueda-Clausen","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2021113010231368500_B95","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvn341","article-title":"Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood","volume":"81","author":"Rueda-Clausen","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2021113010231368500_B96","doi-asserted-by":"crossref","first-page":"H2113","DOI":"10.1152\/ajpheart.00356.2011","article-title":"Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats","volume":"301","author":"Tong","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010231368500_B97","doi-asserted-by":"crossref","first-page":"R583","DOI":"10.1152\/ajpregu.00771.2007","article-title":"Early fetal hypoxia leads to growth restriction and myocardial thinning","volume":"295","author":"Ream","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B98","doi-asserted-by":"crossref","first-page":"H983","DOI":"10.1152\/ajpheart.00005.2003","article-title":"Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart","volume":"285","author":"Bae","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010231368500_B99","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1071-55760300074-1","article-title":"Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat","volume":"10","author":"Li","year":"2003","journal-title":"J. Soc. Gynecol. Investig."},{"key":"2021113010231368500_B100","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1096\/fj.05-4917fje","article-title":"Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring","volume":"20","author":"Xu","year":"2006","journal-title":"FASEB J."},{"key":"2021113010231368500_B101","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.110.221259","article-title":"Chronic prenatal hypoxia induces epigenetic programming of PKC\u03f5 gene repression in rat hearts: novelty and significance","volume":"107","author":"Patterson","year":"2010","journal-title":"Circ. Res."},{"key":"2021113010231368500_B102","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1042\/BST0351052","article-title":"Mitochondrial protein kinase C\u03f5 (PKC\u03f5): emerging role in cardiac protection from ischaemic damage","volume":"35","author":"Budas","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"2021113010231368500_B103","doi-asserted-by":"crossref","first-page":"178.e12","DOI":"10.1016\/j.ajog.2010.09.004","article-title":"Placental microRNA expression in pregnancies complicated by preeclampsia","volume":"204","author":"Enquobahrie","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B104","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004872-199401000-00013","article-title":"Five-year follow-up of blood pressure and left ventricular mass in children with different maternal histories of hypertension: the Hypertension in Pregnancy Offspring Study","volume":"12","author":"Himmelmann","year":"1994","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.earlhumdev.2011.04.006","article-title":"Myocardial function in offspring 5\u20138\u00a0years after pregnancy complicated by preeclampsia","volume":"87","author":"Fugelseth","year":"2011","journal-title":"Early Hum. Dev."},{"key":"2021113010231368500_B106","first-page":"183","article-title":"Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"2021113010231368500_B107","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/CIRCULATIONAHA.108.765701","article-title":"Endothelial function predicts progression of carotid intima-media thickness","volume":"119","author":"Halcox","year":"2009","journal-title":"Circulation"},{"key":"2021113010231368500_B108","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJM199404143301511","article-title":"The endothelium and cardiovascular disease: a complex relation","volume":"330","author":"Luscher","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"2021113010231368500_B109","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ajh.2011.176","article-title":"Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype","volume":"25","author":"Lazdam","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"2021113010231368500_B110","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1161\/01.HYP.0000111832.47667.13","article-title":"Decreased endothelium-dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet","volume":"43","author":"Payne","year":"2004","journal-title":"Hypertension"},{"key":"2021113010231368500_B111","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1016\/j.ajog.2007.10.558","article-title":"Fetal programming of adult vascular function in a preeclampsia-like animal model is gender-specific","volume":"197","author":"Lu","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B112","doi-asserted-by":"crossref","first-page":"H297","DOI":"10.1152\/ajpheart.01284.2010","article-title":"Effect of age and gender on the progression of adult vascular dysfunction in a mouse model of fetal programming lacking endothelial nitric oxide synthase","volume":"301","author":"Chiossi","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010231368500_B113","doi-asserted-by":"crossref","first-page":"R1114","DOI":"10.1152\/ajpregu.00367.2004","article-title":"Fetal origins of adult vascular dysfunction in mice lacking endothelial nitric oxide synthase","volume":"288","author":"Longo","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B114","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/HYPERTENSIONAHA.111.172387","article-title":"Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia","volume":"58","author":"Kvehaugen","year":"2011","journal-title":"Hypertension"},{"key":"2021113010231368500_B115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/HJH.0b013e32834d75c6","article-title":"Endothelial vasodilatation in newborns is related to body size and maternal hypertension","volume":"30","author":"Touwslager","year":"2012","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B116","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9378(96)70045-5","article-title":"Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women","volume":"175","author":"Davidge","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B117","doi-asserted-by":"crossref","first-page":"R930","DOI":"10.1152\/ajpregu.00641.2009","article-title":"Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted","volume":"298","author":"Morton","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B118","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/1933719110385131","article-title":"Enhanced angiogenic capacity of human umbilical vein endothelial cells from women with preeclampsia","volume":"18","author":"Moyes","year":"2011","journal-title":"Reprod. Sci."},{"key":"2021113010231368500_B119","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejogrb.2004.11.015","article-title":"Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia","volume":"122","author":"Staff","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2021113010231368500_B120","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1542\/peds.2004-2240","article-title":"Excess soluble fms-like tyrosine kinase 1 and low platelet counts in premature neonates of preeclamptic mothers","volume":"116","author":"Tsao","year":"2005","journal-title":"Pediatrics"},{"key":"2021113010231368500_B121","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/tropej\/44.1.47","article-title":"Endothelin-1 levels in mothers with eclampsia-pre-eclampsia and their newborns","volume":"44","author":"Orbak","year":"1998","journal-title":"J. Trop. Pediatr."},{"key":"2021113010231368500_B122","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10238-010-0112-7","article-title":"Gene delivery of soluble vascular endothelial growth factor receptor-1 (sFlt-1) inhibits intra-plaque angiogenesis and suppresses development of atherosclerotic plaque","volume":"11","author":"Wang","year":"2011","journal-title":"Clin. Exp. Med."},{"key":"2021113010231368500_B123","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.placenta.2010.12.001","article-title":"The effects of oxygen on normal and pre-eclamptic placental tissue\u2013insights from metabolomics","volume":"32","author":"Heazell","year":"2011","journal-title":"Placenta"},{"key":"2021113010231368500_B124","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00125-006-0558-z","article-title":"Pre-eclampsia and the later development of type\u00a02 diabetes in mothers and their children: an intergenerational study from the Walker cohort","volume":"50","author":"Libby","year":"2007","journal-title":"Diabetologia"},{"key":"2021113010231368500_B125","first-page":"277","article-title":"Macrosomic newborns of diabetic mothers are associated with increased aortic intima-media thickness and lipid concentrations","volume":"67","author":"Akcakus","year":"2007","journal-title":"Horm. Res."},{"key":"2021113010231368500_B126","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/00016340802085318","article-title":"Fetal lipoprotein changes in pre-eclampsia","volume":"87","author":"Catarino","year":"2008","journal-title":"Acta Obstetr. Gynecol. Scand."},{"key":"2021113010231368500_B127","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/tropej\/fmp025","article-title":"Oxidative stress and antioxidant status in neonates born to pre-eclamptic mother","volume":"55","author":"Howlader","year":"2009","journal-title":"J. Trop. Pediatr."},{"key":"2021113010231368500_B128","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1080\/00016340600697272","article-title":"Newborns of pre-eclamptic women: a biochemical difference present in utero","volume":"85","author":"Ophir","year":"2006","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2021113010231368500_B129","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.atherosclerosis.2004.04.026","article-title":"Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction","volume":"176","author":"Rodie","year":"2004","journal-title":"Atherosclerosis"},{"key":"2021113010231368500_B130","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1080\/08035250600589017","article-title":"Cord blood lipoprotein profile after magnesium sulphate treatment in pre-eclamptic patients","volume":"95","author":"Yavuz","year":"2006","journal-title":"Acta Paediatr."},{"key":"2021113010231368500_B131","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/db10-1239","article-title":"Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome","volume":"60","author":"Rueda-Clausen","year":"2011","journal-title":"Diabetes"},{"key":"2021113010231368500_B132","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejogrb.2006.10.005","article-title":"Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis","volume":"131","author":"Medica","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2021113010231368500_B133","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2393-6-7","article-title":"Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis","volume":"6","author":"Yu","year":"2006","journal-title":"BMC Pregnancy Childbirth"},{"key":"2021113010231368500_B134","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1586\/eog.10.58","article-title":"Environmental induction of the fetal epigenome","volume":"5","author":"Odom","year":"2010","journal-title":"Expert Rev. Obstet. Gynecol."},{"key":"2021113010231368500_B135","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ejhg.2010.63","article-title":"DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia","volume":"18","author":"Yuen","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"2021113010231368500_B136","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/hr.2011.9","article-title":"Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas","volume":"34","author":"Gao","year":"2011","journal-title":"Hypertens. Res."},{"key":"2021113010231368500_B137","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.placenta.2009.02.011","article-title":"The H19 gene imprinting in normal pregnancy and pre-eclampsia","volume":"30","author":"Yu","year":"2009","journal-title":"Placenta"},{"key":"2021113010231368500_B138","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nature04048","article-title":"Reversing histone methylation","volume":"436","author":"Bannister","year":"2005","journal-title":"Nature"},{"key":"2021113010231368500_B139","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1523\/JNEUROSCI.3652-05.2005","article-title":"Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life","volume":"25","author":"Weaver","year":"2005","journal-title":"J. Neurosci."},{"key":"2021113010231368500_B140","first-page":"21","article-title":"From gene to epigene-based therapies targeting the vascular endothelium","volume":"21","author":"Lewandowski","year":"2011","journal-title":"Curr. Vasc. Pharmacol."},{"key":"2021113010231368500_B141","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1095\/biolreprod.105.045807","article-title":"Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring","volume":"74","author":"Anderson","year":"2006","journal-title":"Biol. Reprod."},{"key":"2021113010231368500_B142","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/HCO.0b013e328345986e","article-title":"Epigenetics in cardiovascular disease","volume":"26","author":"Shirodkar","year":"2011","journal-title":"Curr. Opin. Cardiol."},{"key":"2021113010231368500_B143","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.bcp.2004.05.042","article-title":"Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-\u03baB and pro-inflammatory gene expression","volume":"68","author":"Rahman","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"2021113010231368500_B144","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"von Zglinicki","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"2021113010231368500_B145","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.freeradbiomed.2010.07.011","article-title":"Oxidative stress in development: Nature or nurture?","volume":"49","author":"Dennery","year":"2010","journal-title":"Free Radical Biol. Med."},{"key":"2021113010231368500_B146","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000052913","article-title":"Lipid peroxidation and antioxidant status in maternal and cord blood","volume":"51","author":"Arikan","year":"2001","journal-title":"Gynecol. Obstet. Invest."},{"key":"2021113010231368500_B147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00404-011-1993-8","article-title":"Comparative study of oxidative stress in maternal blood with that of cord blood and maternal milk","volume":"285","author":"Erdem","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"2021113010231368500_B148","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.placenta.2011.02.004","article-title":"Placental oxidative DNA damage and its repair in preeclamptic women with fetal growth restriction","volume":"32","author":"Fujimaki","year":"2011","journal-title":"Placenta"},{"key":"2021113010231368500_B149","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.siny.2010.04.001","article-title":"Maturation of the antioxidant system and the effects on preterm birth","volume":"15","author":"Davis","year":"2010","journal-title":"Semin. Fetal Neonatal Med."},{"key":"2021113010231368500_B150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/1933719109351597","article-title":"Preeclampsia and HELLP syndrome: impaired mitochondrial function in umbilical endothelial cells","volume":"17","author":"Illsinger","year":"2010","journal-title":"Reprod. Sci."},{"key":"2021113010231368500_B151","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11906-011-0191-1","article-title":"Sympathetic neural mechanisms in human blood pressure regulation","volume":"13","author":"Hart","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"2021113010231368500_B152","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","article-title":"The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors","volume":"141","author":"Thayer","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"2021113010231368500_B153","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1196\/annals.1367.027","article-title":"Birth weight, stress, and the metabolic syndrome in adult life","volume":"1083","author":"Phillips","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2021113010231368500_B154","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1203\/01.pdr.0000196734.54473.e3","article-title":"Maternal preeclampsia predicts elevated blood pressure in 12-year-old children: evaluation by ambulatory blood pressure monitoring","volume":"59","author":"Tenhola","year":"2006","journal-title":"Pediatr. Res."},{"key":"2021113010231368500_B155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/ham.2010.1040","article-title":"Adrenocortical suppression in highland chick embryos is restored during incubation at sea level","volume":"12","author":"Salinas","year":"2011","journal-title":"High Alt. Med. Biol."},{"key":"2021113010231368500_B156","doi-asserted-by":"crossref","first-page":"R1707","DOI":"10.1152\/ajpregu.00343.2005","article-title":"Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus","volume":"289","author":"Myers","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B157","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/1933719109336678","article-title":"Long-term hypoxia increases endothelial nitric oxide synthase expression in the ovine fetal adrenal","volume":"16","author":"Monau","year":"2009","journal-title":"Reprod. Sci."},{"key":"2021113010231368500_B158","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1385\/ENDO:13:1:111","article-title":"The effect of fetal hypoxia on adrenocortical function in the 7-day-old rat","volume":"13","author":"Raff","year":"2000","journal-title":"Endocrine"},{"key":"2021113010231368500_B159","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1681\/ASN.2007010015","article-title":"Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat","volume":"18","author":"Wlodek","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113010231368500_B160","doi-asserted-by":"crossref","first-page":"R1943","DOI":"10.1152\/ajpregu.00558.2006","article-title":"Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension","volume":"292","author":"Baserga","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B161","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.earlhumdev.2008.12.015","article-title":"Uteroplacental insufficiency affects kidney VEGF expression in a model of IUGR with compensatory glomerular hypertrophy and hypertension","volume":"85","author":"Baserga","year":"2009","journal-title":"Early Hum. Dev."},{"key":"2021113010231368500_B162","doi-asserted-by":"crossref","first-page":"R758","DOI":"10.1152\/ajpregu.00311.2006","article-title":"Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring","volume":"292","author":"Ojeda","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B163","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2215\/CJN.03050509","article-title":"Hypertension and the kidney: perspectives on the relationship of kidney disease and cardiovascular disease","volume":"4","author":"Weir","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2021113010231368500_B164","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/ejhg.2011.19","article-title":"Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease","volume":"19","author":"Johansson","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"2021113010231368500_B165","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd2783","article-title":"Unleashing the therapeutic potential of NOD-like receptors","volume":"8","author":"Geddes","year":"2009","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2021113010231368500_B166","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ncb1440","article-title":"SPPL2a and SPPL2b promote intramembrane proteolysis of TNF\u03b1 in activated dendritic cells to trigger IL-12 production","volume":"8","author":"Friedmann","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"2021113010231368500_B167","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","article-title":"Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies","volume":"330","author":"Duckitt","year":"2005","journal-title":"BMJ"},{"key":"2021113010231368500_B168","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/eji.200324469","article-title":"Introducing a mouse model for pre-eclampsia: adoptive transfer of activated Th1 cells leads to pre-eclampsia-like symptoms exclusively in pregnant mice","volume":"34","author":"Zenclussen","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2021113010231368500_B169","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.HYP.0000175476.26719.36","article-title":"Hypertension produced by reductions in uterine perfusion in the pregnant rat","volume":"46","author":"LaMarca","year":"2005","journal-title":"Hypertension"},{"key":"2021113010231368500_B170","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/01.HYP.0000169152.59854.36","article-title":"Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats","volume":"46","author":"LaMarca","year":"2005","journal-title":"Hypertension"},{"key":"2021113010231368500_B171","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni.2001","article-title":"The immune system in atherosclerosis","volume":"12","author":"Hansson","year":"2011","journal-title":"Nat. Immunol."},{"key":"2021113010231368500_B172","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cjca.2010.12.040","article-title":"Chronic inflammatory diseases and cardiovascular risk: a systematic review","volume":"27","author":"Roifman","year":"2011","journal-title":"Can. J. Cardiol."},{"key":"2021113010231368500_B173","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/14767050701412719","article-title":"Comparative analysis of the maternal and umbilical interleukin-8 levels in normal pregnancies and in pregnancies complicated by preeclampsia with intrauterine normal growth and intrauterine growth retardation","volume":"20","author":"Laskowska","year":"2007","journal-title":"J. Matern.-Fetal Neonat. Med."},{"key":"2021113010231368500_B174","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/jmf.14.5.305.312","article-title":"Neonates born to pre-eclamptic mothers have a higher percentage of natural killer cells (CD3\u2212\/CD56+16+) in umbilical cord blood than those without pre-eclampsia","volume":"14","author":"Bujold","year":"2003","journal-title":"J. Matern.-Fetal Neonat. Med."},{"key":"2021113010231368500_B175","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1203\/00006450-200112000-00019","article-title":"Fas and Fas ligand expression in maternal blood and in umbilical cord blood in preeclampsia","volume":"50","author":"Kuntz","year":"2001","journal-title":"Pediatr. Res."},{"key":"2021113010231368500_B176","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0897.1987.tb00129.x","article-title":"Lymphocyte subsets in the neonates of preeclamptic mothers","volume":"14","author":"Baker","year":"1987","journal-title":"Am. J. Reprod. Immunol. Microbiol."},{"key":"2021113010231368500_B177","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.HYP.2.4.130","article-title":"Prepregnant blood pressure, hypertension during pregnancy, and later blood pressure of mothers and offspring","volume":"2","author":"Langford","year":"1980","journal-title":"Hypertension"},{"key":"2021113010231368500_B178","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-3782(89)90061-3","article-title":"Blood pressure and growth at 6\u00a0years of age among offsprings of mothers with hypertension of pregnancy","volume":"19","author":"Palti","year":"1989","journal-title":"Early Hum. Dev."},{"key":"2021113010231368500_B179","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/oxfordjournals.aje.a112882","article-title":"Studies of blood pressure in Tecumseh, Michigan. I. Blood pressure in young people and its relationship to personal and familial characteristics and complications of pregnancy in mothers","volume":"111","author":"Higgins","year":"1980","journal-title":"Am. J. Epidemiol."},{"key":"2021113010231368500_B180","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/01.hjh.0000234114.33025.fd","article-title":"Intrauterine growth restriction increases blood pressure and central pulse pressure measured with telemetry in aging rats","volume":"24","author":"Schreuder","year":"2006","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B181","doi-asserted-by":"crossref","first-page":"398.e1","DOI":"10.1016\/j.ajog.2011.02.031","article-title":"Prepregnancy obesity and sFlt1-induced preeclampsia in mice: developmental programming model of metabolic syndrome","volume":"204","author":"Bytautiene","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B182","doi-asserted-by":"crossref","first-page":"250.e1","DOI":"10.1016\/j.ajog.2008.07.002","article-title":"Transgenerational effect of fetal programming on vascular phenotype and reactivity in endothelial nitric oxide synthase knockout mouse model","volume":"199","author":"Costantine","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B183","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/00003246-198307000-00010","article-title":"Heart rate and blood pressure in infants of pre-eclamptic mothers during the first hour of life","volume":"11","author":"Miller","year":"1983","journal-title":"Crit. Care Med."},{"key":"2021113010231368500_B184","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.3109\/00016349.2010.500368","article-title":"Anthropometry and cardiovascular risk factors in women and offspring after pregnancies complicated by preeclampsia or diabetes mellitus","volume":"89","author":"Kvehaugen","year":"2010","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2021113010231368500_B185","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1479-828X.2007.00696.x","article-title":"Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomised controlled trial","volume":"47","author":"Hiller","year":"2007","journal-title":"Aust. N.Z. J. Obstet. Gynaecol."},{"key":"2021113010231368500_B186","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ajog.2004.05.043","article-title":"Enhanced growth and improved vascular function in offspring from successive pregnancies in endothelial nitric oxide synthase knockout mice","volume":"191","author":"Longo","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B187","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3109\/14767058.2011.556204","article-title":"Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia","volume":"24","author":"Veas","year":"2011","journal-title":"J. Matern.-Fetal Neonatal. Med."},{"key":"2021113010231368500_B188","doi-asserted-by":"crossref","first-page":"432.e1","DOI":"10.1016\/j.ajog.2009.01.044","article-title":"The effect of prepregnancy obesity and sFlt-1-induced preeclampsia-like syndrome on fetal programming of adult vascular function in a mouse model","volume":"200","author":"Byers","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B189","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/jpm.2010.126","article-title":"Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers","volume":"39","author":"Cetinkaya","year":"2011","journal-title":"J. Perinat. Med."},{"key":"2021113010231368500_B190","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/cvr\/cvq303","article-title":"Foetal hypoxia increases cardiac AT2R expression and subsequent vulnerability to adult ischaemic injury","volume":"89","author":"Xue","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2021113010231368500_B191","doi-asserted-by":"crossref","first-page":"155.e7","DOI":"10.1016\/j.ajog.2011.03.015","article-title":"The role of oxidative stress in the developmental origin of adult hypertension","volume":"205","author":"Ghulmiyyah","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B192","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1203\/00006450-200110000-00009","article-title":"Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction","volume":"50","author":"Engelbregt","year":"2001","journal-title":"Pediatr. Res."},{"key":"2021113010231368500_B193","doi-asserted-by":"crossref","first-page":"R1421","DOI":"10.1152\/ajpregu.00096.2010","article-title":"Enhanced sensitivity to acute angiotensin II is testosterone dependent in adult male growth-restricted offspring","volume":"298","author":"Ojeda","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010231368500_B194","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2337\/diabetes.50.10.2279","article-title":"Intrauterine growth retardation leads to the development of Type\u00a02 diabetes in the rat","volume":"50","author":"Simmons","year":"2001","journal-title":"Diabetes"},{"key":"2021113010231368500_B195","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1210\/en.2007-0891","article-title":"Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation","volume":"149","author":"N\u00fcsken","year":"2008","journal-title":"Endocrinology"},{"key":"2021113010231368500_B196","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1096\/fj.10-158188","article-title":"Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring","volume":"25","author":"Camm","year":"2011","journal-title":"FASEB J."},{"key":"2021113010231368500_B197","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000086136","article-title":"Experimental intrauterine growth retardation in the rat causes a reduction of pancreatic \u03b2-cell mass, which persists into adulthood","volume":"88","author":"Styrud","year":"2005","journal-title":"Biol. Neonate"},{"key":"2021113010231368500_B198","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1071\/RD9951227","article-title":"Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia","volume":"7","author":"Goland","year":"1995","journal-title":"Reprod. Fertil. Dev."},{"key":"2021113010231368500_B199","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0028-2243(91)90136-9","article-title":"Corticotropin-releasing hormone in maternal and cord plasma in pre-eclampsia","volume":"39","author":"Laatikainen","year":"1991","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2021113010231368500_B200","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1097\/00004872-199917090-00002","article-title":"Effect of intrauterine growth restriction on blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3\u20134 months of age","volume":"17","author":"Jansson","year":"1999","journal-title":"J. Hypertens."},{"key":"2021113010231368500_B201","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.placenta.2009.01.012","article-title":"Differential placental gene expression in severe preeclampsia","volume":"30","author":"Sitras","year":"2009","journal-title":"Placenta"},{"key":"2021113010231368500_B202","doi-asserted-by":"crossref","first-page":"661.e1","DOI":"10.1016\/j.ajog.2008.12.045","article-title":"Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies","volume":"200","author":"Zhu","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B203","doi-asserted-by":"crossref","first-page":"787545","DOI":"10.1155\/2010\/787545","article-title":"Gene expression profiling of placentas affected by pre-eclampsia","volume":"2010","author":"Hoegh","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"2021113010231368500_B204","doi-asserted-by":"crossref","first-page":"472354","DOI":"10.1155\/2011\/472354","article-title":"Differential gene expression analysis of placentas with increased vascular resistance and pre-eclampsia using whole-genome microarrays","volume":"2011","author":"Centlow","year":"2011","journal-title":"J. Pregnancy"},{"key":"2021113010231368500_B205","doi-asserted-by":"crossref","first-page":"84.e1","DOI":"10.1016\/j.ajog.2010.08.043","article-title":"A transcriptional profile of the decidua in preeclampsia","volume":"204","author":"Loset","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021113010231368500_B206","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.placenta.2010.04.014","article-title":"Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar","volume":"32","author":"V\u00e1rkonyi","year":"2011","journal-title":"Placenta"},{"key":"2021113010231368500_B207","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1447-0756.2010.01346.x","article-title":"Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method","volume":"37","author":"Ozturk","year":"2011","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"2021113010231368500_B208","doi-asserted-by":"crossref","first-page":"418.e1","DOI":"10.1016\/j.ajog.2010.12.010","article-title":"Blood protein profiles of infants born before 28\u00a0weeks differ by pregnancy complication","volume":"204","author":"McElrath","year":"2011","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/123\/2\/53\/441547\/cs1230053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/123\/2\/53\/441547\/cs1230053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T10:52:38Z","timestamp":1638269558000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/123\/2\/53\/69023\/Pre-eclampsia-and-offspring-cardiovascular-health"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,23]]},"references-count":208,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20110627","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,23]]}}}