{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:52:26Z","timestamp":1791280346203,"version":"4.1.0"},"reference-count":31,"publisher":"Portland Press Ltd.","issue":"7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:p>Epidemiological studies revealed an association between IUGR (intrauterine growth restriction) and an increased risk of developing CVDs (cardiovascular diseases), such as atherosclerosis or hypertension, in later life. Whether or not IUGR contributes to the development of atherosclerotic lesions, however, is unclear. We tested the hypothesis that IUGR aggravates experimentally induced vascular remodelling. IUGR was induced in rats by maternal protein restriction during pregnancy (8% protein diet). To detect possible differences in the development of vascular injury, a model of carotid artery ligation to induce vascular remodelling was applied in 8-week-old intrauterine-growth-restricted and control rat offspring. Histological and immunohistochemical analyses were performed in the ligated and non-ligated carotid arteries 8\u00a0weeks after ligation. IUGR alone neither caused overt histological changes nor significant dedifferentiation of VSMCs (vascular smooth muscle cells). After carotid artery ligation, however, neointima formation, media thickness and media\/lumen ratio were significantly increased in rats after IUGR compared with controls. Moreover, dedifferentiation of VSMCs and collagen deposition in the media were more prominent in ligated carotids from rats after IUGR compared with ligated carotids from control rats. We conclude that IUGR aggravates atherosclerotic vascular remodelling induced by a second injury later in life.<\/jats:p>","DOI":"10.1042\/cs20110637","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T08:36:23Z","timestamp":1335256583000},"page":"437-444","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats"],"prefix":"10.1042","volume":"123","author":[{"given":"Carlos","family":"Menendez-Castro","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Cordasic","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Fahlbusch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rascher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Nephropathology, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl\u00a0F.","family":"Hilgers","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hartner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, University of Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,6,7]]},"reference":[{"key":"2021113010251389400_B1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1542\/peds.2007-1801","article-title":"Intrauterine risk factors for precocious atherosclerosis","volume":"121","author":"Skilton","year":"2008","journal-title":"Pediatrics"},{"key":"2021113010251389400_B2","doi-asserted-by":"crossref","first-page":"H1321","DOI":"10.1152\/ajpheart.00440.2008","article-title":"Hypoxia during pregnancy in rats leads to early morphological changes of atherosclerosis in adult offspring","volume":"296","author":"Wang","year":"2009","journal-title":"Am. 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