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Conversely, high doses of Mg2+ salts, frequently administered as an antacid or a laxative, may lead to hypermagnesaemia causing various cardiovascular and neuromuscular abnormalities. A better understanding of the molecular mechanisms underlying the adverse effects of these medications on Mg2+ balance will indicate ways of prevention and treatment of these adverse effects and could potentially provide more insight into Mg2+ homoeostasis.<\/jats:p>","DOI":"10.1042\/cs20120045","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T13:23:23Z","timestamp":1331645003000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Drug-induced alterations in Mg2+ homoeostasis"],"prefix":"10.1042","volume":"123","author":[{"given":"Anke\u00a0L.","family":"Lameris","sequence":"first","affiliation":[{"name":"Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo\u00a0A.","family":"Monnens","sequence":"additional","affiliation":[{"name":"Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9\u00a0J.","family":"Bindels","sequence":"additional","affiliation":[{"name":"Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost\u00a0G.\u00a0J.","family":"Hoenderop","sequence":"additional","affiliation":[{"name":"Department of Physiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2012,3,12]]},"reference":[{"key":"2021113010224739600_B1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1681\/ASN.2005070700","article-title":"The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens","volume":"17","author":"Groenestege","year":"2006","journal-title":"J. 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