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The role of magnesium in cancer is also critically examined with regard to mitochondrial function, apoptosis and resistance to treatment. Finally, we bring together the latest experimental evidence indicating that alteration in the expression and\/or activity of magnesium channels is a frequent finding in cancer cells and human tumour tissues examined to date, and we discuss the potential implications for developing novel diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.1042\/cs20120086","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T09:12:12Z","timestamp":1339060332000},"page":"417-427","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Magnesium and its transporters in cancer: a novel paradigm in tumour development"],"prefix":"10.1042","volume":"123","author":[{"given":"Federica\u00a0I.","family":"Wolf","sequence":"first","affiliation":[{"name":"Istituto di Patologia Generale, Facolt\u00e0 di Medicina e Chirurgia \u201cA. Gemelli\u201d, Universit\u00e0 Cattolica del Sacro Cuore, Largo F. 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