{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:22Z","timestamp":1760549302073},"reference-count":36,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:p>In rats with experimental liver cirrhosis, the kidney contains reduced amounts of membrane-bound CaRs (calcium-sensing receptors), and the specific stimulation of CaRs causes the generation of PGE2 (prostaglandin E2), renal vasodilation and increased natriuresis. CaR content and function in the liver of cirrhotic rats are unknown. To assess the activity of this Ca2+-dependent vasomotor system, we evaluated the effects of intravenous administration of PolyAg (poly-L-arginine), a selective CaR agonist, on hormonal status, portal haemodynamics, MAP (mean arterial pressure) in rats with liver cirrhosis induced by chronic CCl4 (carbon tetrachloride) administration. Two groups of eight control rats received intravenously 1\u00a0ml of 5% (w\/v) glucose solution alone or containing 0.5\u00a0mg of PolyAg; two groups of ten cirrhotic rats were administered vehicle or PolyAg. Compared with controls, at baseline cirrhotic rats showed higher portal pressure (P&amp;lt;0.01), lower estimated functional liver plasma flow, measured as CICG (Indocyanine Green clearance) (P&amp;lt;0.03) and reduced hepatic protein content of CaRs (P&amp;lt;0.03), which were located mainly in sub-endothelial layers of portal venules and in myofibroblasts of fibrotic septa (immunohistochemistry and indirect immunofluorescence staining of liver sections). In cirrhotic animals, 0.5\u00a0mg of PolyAg decreased portal pressure (P&amp;lt;0.01) and increased CICG (P&amp;lt;0.05), without effects on arterial pressure and hormonal status. In conclusion, the present study provides evidence that in experimental cirrhosis agonists of liver CaRs elicit beneficial portal hypotensive effects by reducing intrahepatic resistance to portal flow. Moreover, these drugs are devoid of effects on systemic haemodynamics.<\/jats:p>","DOI":"10.1042\/cs20120476","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T10:17:53Z","timestamp":1360232273000},"page":"67-75","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis"],"prefix":"10.1042","volume":"125","author":[{"given":"Giovanni","family":"Sanso\u00e8","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Gradenigo Hospital, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Aragno","sequence":"additional","affiliation":[{"name":"Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Mastrocola","sequence":"additional","affiliation":[{"name":"Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Paternostro","sequence":"additional","affiliation":[{"name":"Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Parola","sequence":"additional","affiliation":[{"name":"Unit of Experimental Medicine and Clinical Pathology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"2021113010282504600_B1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/jhep.2002.31432","article-title":"The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough","volume":"35","author":"Wiest","year":"2002","journal-title":"Hepatology"},{"key":"2021113010282504600_B2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1089-3261(05)70253-1","article-title":"Natural history of portal hypertension","volume":"1","author":"Boyer","year":"1997","journal-title":"Clin. 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