{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:00:41Z","timestamp":1789189241934,"version":"build-2803163510"},"reference-count":150,"publisher":"Portland Press Ltd.","issue":"9","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:p>MR (mineralocorticoid receptor) activation in the heart plays a central role in the development of cardiovascular disease, including heart failure. The MR is present in many cell types\u00a0within the myocardium, including cardiomyocytes, macrophages and the coronary vasculature. The specific role of the MR in each of these cell types\u00a0in the initiation and progression of cardiac pathophysiology is not fully understood. Cardiomyocyte MRs are increasingly recognized to play a role in regulating cardiac function, electrical conduction and fibrosis, through direct signal mediation and through paracrine MR-dependent activity. Although MR blockade in the heart is an attractive therapeutic option for the treatment of heart failure and other forms of heart disease, current antagonists are limited by side effects owing to MR inactivation in other tissues (including renal targets). This has led to increased efforts to develop therapeutics that are more selective for cardiac MRs and which may have reduced the occurrence of side effects in non-cardiac tissues. A major clinical consideration in the treatment of cardiovascular disease is of the differences between males and females in the incidence and outcomes of cardiac events. There is clinical evidence that female sensitivity to endogenous MRs is more pronounced, and experimentally that MR-targeted interventions may be more efficacious in females. Given that sex differences have been described in MR signalling in a range of experimental settings and that the MR and oestrogen receptor pathways share some common signalling intermediates, it is becoming increasingly apparent that the mechanisms of MRs need to be evaluated in a sex-selective manner. Further research targeted to identify sex differences in cardiomyocyte MR activation and signalling processes has the potential to provide the basis for the development of cardiac-specific MR therapies that may also be sex-specific.<\/jats:p>","DOI":"10.1042\/cs20130050","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T11:16:51Z","timestamp":1372331811000},"page":"409-421","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mineralocorticoid receptors and the heart, multiple cell types\u00a0and multiple mechanisms: a focus on the cardiomyocyte"],"prefix":"10.1042","volume":"125","author":[{"given":"Laura\u00a0A.","family":"Bienvenu","sequence":"first","affiliation":[{"name":"Prince Henry's Institute of Medical Research, Clayton, VIC 3168, Australia"},{"name":"Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa\u00a0E.","family":"Reichelt","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea\u00a0M. D.","family":"Delbridge","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag\u00a0J.","family":"Young","sequence":"additional","affiliation":[{"name":"Prince Henry's Institute of Medical Research, Clayton, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"2021113010284998600_B1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2021113010284998600_B2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"2021113010284998600_B3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"2021113010284998600_B4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1042\/CS20060275","article-title":"Mineralocorticoid receptor activation and cardiac fibrosis","volume":"112","author":"Young","year":"2007","journal-title":"Clin. Sci."},{"key":"2021113010284998600_B5","doi-asserted-by":"crossref","first-page":"12A","DOI":"10.1016\/0002-9149(93)90239-9","article-title":"Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension","volume":"71","author":"Brilla","year":"1993","journal-title":"Am. J. Cardiol."},{"key":"2021113010284998600_B6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0896-6273(88)90136-5","article-title":"The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response","volume":"1","author":"Arriza","year":"1988","journal-title":"Neuron"},{"key":"2021113010284998600_B7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/j.1440-1681.1987.tb02422.x","article-title":"High affinity aldosterone binding sites (type I receptors) in rat heart","volume":"14","author":"Pearce","year":"1987","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2021113010284998600_B8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.71.3.503","article-title":"Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor","volume":"71","author":"Lombes","year":"1992","journal-title":"Circ. Res."},{"key":"2021113010284998600_B9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/01.CIR.92.2.175","article-title":"Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 \u03b2-hydroxysteroid dehydrogenase in the human heart","volume":"92","author":"Lombes","year":"1995","journal-title":"Circulation"},{"key":"2021113010284998600_B10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1210\/endo.143.1.8583","article-title":"11\u03b2-Hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart","volume":"143","author":"Sheppard","year":"2002","journal-title":"Endocrinology"},{"key":"2021113010284998600_B11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mce.2011.07.020","article-title":"Tissue-specific modulation of mineralocorticoid receptor function by 11\u03b2-hydroxysteroid dehydrogenases: an overview","volume":"350","author":"Odermatt","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113010284998600_B12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1677\/JME-09-0031","article-title":"The mineralocorticoid receptor and its coregulators","volume":"43","author":"Yang","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"2021113010284998600_B13","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/en.2010-0099","article-title":"The mineralocorticoid receptor is a constitutive nuclear factor in cardiomyocytes due to hyperactive nuclear localization signals","volume":"151","author":"Hernandez-Diaz","year":"2010","journal-title":"Endocrinology"},{"key":"2021113010284998600_B14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1210\/en.2005-0860","article-title":"Development of a panel of monoclonal antibodies against the mineralocorticoid receptor","volume":"147","author":"Gomez-Sanchez","year":"2006","journal-title":"Endocrinology"},{"key":"2021113010284998600_B15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/01.RES.76.6.973","article-title":"Nongenomic effects of aldosterone on intracellular Ca2+ in vascular smooth muscle cells","volume":"76","author":"Wehling","year":"1995","journal-title":"Circ. Res."},{"key":"2021113010284998600_B16","doi-asserted-by":"crossref","first-page":"C5","DOI":"10.1016\/0303-7207(92)90092-K","article-title":"Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids","volume":"90","author":"Wehling","year":"1992","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113010284998600_B17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.mce.2011.07.019","article-title":"Non-genomic actions of aldosterone: from receptors and signals to membrane targets","volume":"350","author":"Dooley","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113010284998600_B18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1210\/er.2005-0004","article-title":"The nongenomic actions of aldosterone","volume":"26","author":"Funder","year":"2005","journal-title":"Endocr. Rev."},{"key":"2021113010284998600_B19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jsbmb.2007.09.005","article-title":"Rapid responses to aldosterone in the kidney and colon","volume":"108","author":"Harvey","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2021113010284998600_B20","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.steroids.2008.01.013","article-title":"Aldosterone-induced signalling and cation transport in the distal nephron","volume":"73","author":"Thomas","year":"2008","journal-title":"Steroids"},{"key":"2021113010284998600_B21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-physiol-012110-142222","article-title":"Mechanisms underlying rapid aldosterone effects in the kidney","volume":"73","author":"Thomas","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"2021113010284998600_B22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1139\/y11-062","article-title":"Delineating the receptor mechanisms underlying the rapid vascular contractile effects of aldosterone and estradiol","volume":"89","author":"Gros","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2021113010284998600_B23","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/HYPERTENSIONAHA.110.165076","article-title":"GPR30, mineralocorticoid receptors, and the rapid vascular effects of aldosterone","volume":"57","author":"Funder","year":"2011","journal-title":"Hypertension"},{"key":"2021113010284998600_B24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/HYPERTENSIONAHA.110.161653","article-title":"GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone","volume":"57","author":"Gros","year":"2011","journal-title":"Hypertension"},{"key":"2021113010284998600_B25","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.steroids.2011.12.023","article-title":"Nongenomic actions of aldosterone and progesterone revisited","volume":"77","author":"Wendler","year":"2012","journal-title":"Steroids"},{"key":"2021113010284998600_B26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tcm.2010.05.001","article-title":"Estrogen receptor activation and cardioprotection in ischemia reperfusion injury","volume":"20","author":"Deschamps","year":"2010","journal-title":"Trends Cardiovasc. Med."},{"key":"2021113010284998600_B27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.3037703","article-title":"Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor","volume":"237","author":"Arriza","year":"1987","journal-title":"Science"},{"key":"2021113010284998600_B28","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/endo-128-4-2129","article-title":"Localization of renal 11 \u03b2-dehydrogenase by in situ hybridization: autocrine not paracrine protector of the mineralocorticoid receptor","volume":"128","author":"Stewart","year":"1991","journal-title":"Endocrinology"},{"key":"2021113010284998600_B29","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(88)90742-8","article-title":"Localisation of 11 \u03b2-hydroxysteroid dehydrogenase: tissue specific protector of the mineralocorticoid receptor","volume":"2","author":"Edwards","year":"1988","journal-title":"Lancet"},{"key":"2021113010284998600_B30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.2845584","article-title":"Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated","volume":"242","author":"Funder","year":"1988","journal-title":"Science"},{"key":"2021113010284998600_B31","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1016\/0303-7207(94)90176-7","article-title":"Cloning and tissue distribution of the human 11 \u03b2-hydroxysteroid dehydrogenase type\u00a02 enzyme","volume":"105","author":"Albiston","year":"1994","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113010284998600_B32","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0039-128X(94)90087-6","article-title":"Isozymes of 11 \u03b2-hydroxysteroid dehydrogenase: which enzyme endows mineralocorticoid specificity?","volume":"59","author":"Krozowski","year":"1994","journal-title":"Steroids"},{"key":"2021113010284998600_B33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1073\/pnas.0503878102","article-title":"Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity","volume":"103","author":"Berger","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010284998600_B34","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1210\/endo.137.12.8940344","article-title":"Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in\u00a0vivo binding studies","volume":"137","author":"Funder","year":"1996","journal-title":"Endocrinology"},{"key":"2021113010284998600_B35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/HYPERTENSIONAHA.108.119966","article-title":"Reconsidering the roles of the mineralocorticoid receptor","volume":"53","author":"Funder","year":"2009","journal-title":"Hypertension"},{"key":"2021113010284998600_B36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1161\/hc3001.091458","article-title":"Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries","volume":"104","author":"Ward","year":"2001","journal-title":"Circulation"},{"key":"2021113010284998600_B37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1042\/CS20080247","article-title":"Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart","volume":"116","author":"Wilson","year":"2009","journal-title":"Clin. Sci."},{"key":"2021113010284998600_B38","doi-asserted-by":"crossref","first-page":"F181","DOI":"10.1152\/ajprenal.2001.280.2.F181","article-title":"Multiple aspects of mineralocorticoid selectivity","volume":"280","author":"Farman","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021113010284998600_B39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0303-7207(02)00413-6","article-title":"Interdomain interactions in the mineralocorticoid receptor","volume":"200","author":"Rogerson","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"2021113010284998600_B40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1677\/JME-08-0093","article-title":"Structure\u2013function relationships in the mineralocorticoid receptor","volume":"41","author":"Pippal","year":"2008","journal-title":"J. Mol. Endocrinol."},{"key":"2021113010284998600_B41","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/eurheartj\/ehm091","article-title":"A propensity-matched study of the association of low serum potassium levels and mortality in chronic heart failure","volume":"28","author":"Ahmed","year":"2007","journal-title":"Eur. Heart J."},{"key":"2021113010284998600_B42","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/01.CIR.0000091405.00772.6E","article-title":"Effects of eplerenone, enalapril, and eplerenone\/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study","volume":"108","author":"Pitt","year":"2003","journal-title":"Circulation"},{"key":"2021113010284998600_B43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2021113010284998600_B44","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/eurjhf\/hfs067","article-title":"Eplerenone and new-onset diabetes in patients with mild heart failure: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)","volume":"14","author":"Preiss","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"2021113010284998600_B45","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/eurjhf\/hfq049","article-title":"Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF)","volume":"12","author":"Zannad","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"2021113010284998600_B46","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jacc.2011.11.063","article-title":"Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study","volume":"59","author":"Swedberg","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010284998600_B47","first-page":"50","article-title":"Aldosterone and aldosterone antagonists in cardiac disease: what is known, what is new","volume":"2","author":"Catena","year":"2012","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"2021113010284998600_B48","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cardfail.2011.04.007","article-title":"Results of the Randomized Aldosterone Antagonism in Heart Failure with Preserved Ejection Fraction trial (RAAM-PEF)","volume":"17","author":"Deswal","year":"2011","journal-title":"J. Card. Fail."},{"key":"2021113010284998600_B49","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.numecd.2010.02.012","article-title":"Effect of canrenone on left ventricular mechanics in patients with mild systolic heart failure and metabolic syndrome: the AREA-in-CHF study","volume":"21","author":"de Simone","year":"2011","journal-title":"Nutr., Metab. Cardiovasc. Dis."},{"key":"2021113010284998600_B50","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.0000138680.89536.A9","article-title":"Effect of aldosterone antagonism on myocardial dysfunction in hypertensive patients with diastolic heart failure","volume":"110","author":"Mottram","year":"2004","journal-title":"Circulation"},{"key":"2021113010284998600_B51","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/cmdc.201200081","article-title":"Discovery of BAY 94\u20138862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases","volume":"7","author":"Barfacker","year":"2012","journal-title":"ChemMedChem"},{"key":"2021113010284998600_B52","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/eurjhf\/hfs061","article-title":"Rationale and design of ARTS: a randomized, double-blind study of BAY 94\u20138862\u00a0in patients with chronic heart failure and mild or moderate chronic kidney disease","volume":"14","author":"Pitt","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"2021113010284998600_B53","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jacc.2009.09.045","article-title":"Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation","volume":"55","author":"Tsai","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010284998600_B54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archinternmed.2007.33","article-title":"Cardiovascular outcomes in patients with primary aldosteronism after treatment","volume":"168","author":"Catena","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"2021113010284998600_B55","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism","volume":"45","author":"Milliez","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010284998600_B56","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.amjcard.2010.07.037","article-title":"Effect of combined spironolactone-beta-blocker\u00b1enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study)","volume":"106","author":"Dabrowski","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"2021113010284998600_B57","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/clc.20762","article-title":"The effect of aldosterone antagonists for ventricular arrhythmia: a meta-analysis","volume":"33","author":"Wei","year":"2010","journal-title":"Clin. Cardiol."},{"key":"2021113010284998600_B58","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1472-8206.2010.00873.x","article-title":"Gender-specific aspects in the clinical presentation of cardiovascular disease","volume":"24","author":"Leuzzi","year":"2010","journal-title":"Fundam. Clin. Pharmacol."},{"key":"2021113010284998600_B59","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11897-012-0107-7","article-title":"Gender differences in the pathophysiology, clinical presentation, and outcomes of ischemic heart failure","volume":"9","author":"Dunlay","year":"2012","journal-title":"Curr. Heart Fail. Rep."},{"key":"2021113010284998600_B60","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0008-6363(00)00005-5","article-title":"The roles of gender, the menopause and hormone replacement on cardiovascular function","volume":"46","author":"Hayward","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"2021113010284998600_B61","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"Mendelsohn","year":"2005","journal-title":"Science"},{"key":"2021113010284998600_B62","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jacc.2004.11.054","article-title":"Gender and myocardial salvage after reperfusion treatment in acute myocardial infarction","volume":"45","author":"Mehilli","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010284998600_B63","first-page":"865","article-title":"Heart protein expression related to age and sex in mice and humans","volume":"20","author":"Diedrich","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"2021113010284998600_B64","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/eurheartj\/ehi397","article-title":"Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases","volume":"26","author":"Jochmann","year":"2005","journal-title":"Eur. Heart J."},{"key":"2021113010284998600_B65","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1124\/mol.109.056705","article-title":"Sex differences in the expression of hepatic drug metabolizing enzymes","volume":"76","author":"Waxman","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"2021113010284998600_B66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/1470320311414453","article-title":"Suppression of aldosterone mediates regression of left ventricular hypertrophy in patients with hypertension","volume":"12","author":"Pouleur","year":"2011","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"2021113010284998600_B67","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1210\/en.2002-220120","article-title":"Selective aldosterone blockade prevents angiotensin II\/salt-induced vascular inflammation in the rat heart","volume":"143","author":"Rocha","year":"2002","journal-title":"Endocrinology"},{"key":"2021113010284998600_B68","doi-asserted-by":"crossref","first-page":"H1802","DOI":"10.1152\/ajpheart.01096.2001","article-title":"Aldosterone induces a vascular inflammatory phenotype in the rat heart","volume":"283","author":"Rocha","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010284998600_B69","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart: role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2021113010284998600_B70","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/FJC.0b013e318258f8ce","article-title":"Additive amelioration of oxidative stress and cardiac function by combined mineralocorticoid and angiotensin receptor blockers in postinfarct failing hearts","volume":"60","author":"Noda","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021113010284998600_B71","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/HYPERTENSIONAHA.111.185520","article-title":"Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes: role of small GTPase Rac1","volume":"59","author":"Nagase","year":"2012","journal-title":"Hypertension"},{"key":"2021113010284998600_B72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCULATIONAHA.110.983023","article-title":"Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction","volume":"123","author":"Fraccarollo","year":"2011","journal-title":"Circulation"},{"key":"2021113010284998600_B73","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/HYPERTENSIONAHA.112.203158","article-title":"Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone\/salt-mediated inflammation and cardiac fibrosis","volume":"60","author":"Rickard","year":"2012","journal-title":"Hypertension"},{"key":"2021113010284998600_B74","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/HYPERTENSIONAHA.110.163287","article-title":"Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function","volume":"57","author":"Lother","year":"2011","journal-title":"Hypertension"},{"key":"2021113010284998600_B75","doi-asserted-by":"crossref","first-page":"H2035","DOI":"10.1152\/ajpheart.00552.2010","article-title":"Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression","volume":"300","author":"Favre","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010284998600_B76","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1210\/en.2012-1780","article-title":"Corticosteroids, heart failure, and hypertension: a role for immune cells?","volume":"153","author":"Shen","year":"2012","journal-title":"Endocrinology"},{"key":"2021113010284998600_B77","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.109.131110","article-title":"Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone\/salt-induced cardiac fibrosis and increased blood pressure","volume":"54","author":"Rickard","year":"2009","journal-title":"Hypertension"},{"key":"2021113010284998600_B78","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1210\/en.2011-2098","article-title":"Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis","volume":"153","author":"Bienvenu","year":"2012","journal-title":"Endocrinology"},{"key":"2021113010284998600_B79","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1172\/JCI41080","article-title":"Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice","volume":"120","author":"Usher","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2021113010284998600_B80","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1677\/JME-08-0144","article-title":"Corticosteroid receptors, macrophages and cardiovascular disease","volume":"42","author":"Rickard","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"2021113010284998600_B81","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1476-5381.2010.01199.x","article-title":"Glucocorticosteroids: current and future directions","volume":"163","author":"Barnes","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"2021113010284998600_B82","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/rheumatology\/ker215","article-title":"Dynamic regulation of glucocorticoid signalling in health and disease","volume":"51","author":"Biddie","year":"2012","journal-title":"Rheumatology"},{"key":"2021113010284998600_B83","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.RES.0000080521.15238.E5","article-title":"Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure","volume":"93","author":"Qin","year":"2003","journal-title":"Circ. Res."},{"key":"2021113010284998600_B84","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.steroids.2005.02.004","article-title":"Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system","volume":"70","author":"Mihailidou","year":"2005","journal-title":"Steroids"},{"key":"2021113010284998600_B85","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1161\/HYPERTENSIONAHA.108.114223","article-title":"Corticosteroids and redox potential modulate spontaneous contractions in isolated rat ventricular cardiomyocytes","volume":"52","author":"Rossier","year":"2008","journal-title":"Hypertension"},{"key":"2021113010284998600_B86","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1210\/en.2010-0237","article-title":"Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart","volume":"151","author":"Latouche","year":"2010","journal-title":"Endocrinology"},{"key":"2021113010284998600_B87","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/HYPERTENSIONAHA.112.198986","article-title":"Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in\u00a0vivo","volume":"61","author":"Messaoudi","year":"2013","journal-title":"Hypertension"},{"key":"2021113010284998600_B88","first-page":"893","article-title":"Mineralocorticoid excess, dietary sodium, and myocardial fibrosis","volume":"120","author":"Brilla","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"2021113010284998600_B89","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1172\/JCI117269","article-title":"Mineralocorticoids, hypertension, and cardiac fibrosis","volume":"93","author":"Young","year":"1994","journal-title":"J. Clin. Invest."},{"key":"2021113010284998600_B90","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1056\/NEJMra000050","article-title":"Aldosterone in congestive heart failure","volume":"345","author":"Weber","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2021113010284998600_B91","first-page":"E657","article-title":"Determinants of cardiac fibrosis in experimental hypermineralocorticoid states","volume":"269","author":"Young","year":"1995","journal-title":"Am. J. Physiol."},{"key":"2021113010284998600_B92","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1210\/en.2004-0005","article-title":"Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone\/salt-treated rats","volume":"145","author":"Young","year":"2004","journal-title":"Endocrinology"},{"key":"2021113010284998600_B93","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.HYP.26.6.971","article-title":"Biological determinants of aldosterone-induced cardiac fibrosis in rats","volume":"26","author":"Robert","year":"1995","journal-title":"Hypertension"},{"key":"2021113010284998600_B94","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/endo.142.8.8339","article-title":"Experimental cardiac fibrosis: differential time course of responses to mineralocorticoid-salt administration","volume":"142","author":"Fujisawa","year":"2001","journal-title":"Endocrinology"},{"key":"2021113010284998600_B95","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","article-title":"Cardiac interstitium in health and disease: the fibrillar collagen network","volume":"13","author":"Weber","year":"1989","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010284998600_B96","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1999.79.1.215","article-title":"Molecular mechanisms of myocardial remodeling","volume":"79","author":"Swynghedauw","year":"1999","journal-title":"Physiol. Rev."},{"key":"2021113010284998600_B97","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1006\/jmcc.2000.1129","article-title":"Induction of cardiac fibrosis by aldosterone","volume":"32","author":"Lijnen","year":"2000","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113010284998600_B98","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0039-128X(96)00020-7","article-title":"Mineralocorticoids, salt, hypertension: effects on the heart","volume":"61","author":"Young","year":"1996","journal-title":"Steroids"},{"key":"2021113010284998600_B99","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/HYPERTENSIONAHA.110.159277","article-title":"Dietary sodium, aldosterone, and left ventricular mass changes during long-term inhibition of the renin-angiotensin system","volume":"56","author":"du Cailar","year":"2010","journal-title":"Hypertension"},{"key":"2021113010284998600_B100","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1172\/JCI115849","article-title":"Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage","volume":"90","author":"Baylis","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2021113010284998600_B101","first-page":"298","article-title":"Chronic inhibition of nitric oxide synthesis","volume":"20","author":"Ribeiro","year":"1992","journal-title":"A new model of arterial hypertension. Hypertension"},{"key":"2021113010284998600_B102","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1172\/JCI115906","article-title":"Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase","volume":"90","author":"Arnal","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2021113010284998600_B103","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1097\/00004872-199212000-00019","article-title":"Deficient production of nitric oxide induces volume-dependent hypertension","volume":"10","author":"Lahera","year":"1992","journal-title":"J. Hypertens."},{"key":"2021113010284998600_B104","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10557-006-8130-0","article-title":"The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats","volume":"20","author":"Tsukamoto","year":"2006","journal-title":"Cardiovasc. Drugs Ther."},{"key":"2021113010284998600_B105","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1161\/01.HYP.0000176236.55322.18","article-title":"Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes","volume":"46","author":"Rude","year":"2005","journal-title":"Hypertension"},{"key":"2021113010284998600_B106","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/cvr\/28.12.1863","article-title":"Aldosterone and cardiac fibrosis: in\u00a0vitro studies","volume":"28","author":"Fullerton","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"2021113010284998600_B107","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(97)01179-4","article-title":"Cardiac myocytes and fibroblasts contain functional estrogen receptors","volume":"416","author":"Grohe","year":"1997","journal-title":"FEBS Lett."},{"key":"2021113010284998600_B108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/humupd\/6.3.225","article-title":"Steroid hormone receptors: an update","volume":"6","author":"Beato","year":"2000","journal-title":"Hum. Reprod. Update."},{"key":"2021113010284998600_B109","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/HYPERTENSIONAHA.110.166157","article-title":"Estrogen receptor-\u03b2 signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice","volume":"57","author":"Gurgen","year":"2011","journal-title":"Hypertension"},{"key":"2021113010284998600_B110","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/HYPERTENSIONAHA.111.00276","article-title":"Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model","volume":"61","author":"Gurgen","year":"2013","journal-title":"Hypertension"},{"key":"2021113010284998600_B111","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/HYPERTENSIONAHA.107.107938","article-title":"Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism","volume":"51","author":"Karatas","year":"2008","journal-title":"Hypertension"},{"key":"2021113010284998600_B112","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/01.HYP.31.1.403","article-title":"Role of the adrenal medullae in male and female DOCA-salt hypertensive rats","volume":"31","author":"Lange","year":"1998","journal-title":"Hypertension"},{"key":"2021113010284998600_B113","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.HYP.9.2.172","article-title":"Sex difference in the development of deoxycorticosterone-salt hypertension in the rat","volume":"9","author":"Ouchi","year":"1987","journal-title":"Hypertension"},{"key":"2021113010284998600_B114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-0031-1299774","article-title":"Sex-specific effects of spironolactone on blood pressure in gonadectomized male and female Wistar rats","volume":"44","author":"Michaelis","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"2021113010284998600_B115","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/01.HYP.0000124253.98863.86","article-title":"Is the female heart more sensitive to aldosterone for early remodeling?","volume":"43","author":"Duprez","year":"2004","journal-title":"Hypertension"},{"key":"2021113010284998600_B116","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1161\/01.HYP.0000124251.06056.8e","article-title":"Relations of serum aldosterone to cardiac structure: gender-related differences in the Framingham Heart Study","volume":"43","author":"Vasan","year":"2004","journal-title":"Hypertension"},{"key":"2021113010284998600_B117","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/hrt.77.1.24","article-title":"Associations between circulating components of the renin-angiotensin-aldosterone system and left ventricular mass","volume":"77","author":"Schunkert","year":"1997","journal-title":"Heart"},{"key":"2021113010284998600_B118","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1210\/en.2009-1375","article-title":"Contribution of mineralocorticoid and glucocorticoid receptors to the chronotropic and hypertrophic actions of aldosterone in neonatal rat ventricular myocytes","volume":"151","author":"Rossier","year":"2010","journal-title":"Endocrinology"},{"key":"2021113010284998600_B119","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1210\/en.2008-1727","article-title":"Role of the T-type calcium channel CaV3.2\u00a0in the chronotropic action of corticosteroids in isolated rat ventricular myocytes","volume":"150","author":"Maturana","year":"2009","journal-title":"Endocrinology"},{"key":"2021113010284998600_B120","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1161\/CIRCULATIONAHA.108.805804","article-title":"Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins","volume":"119","author":"Gomez","year":"2009","journal-title":"Circulation"},{"key":"2021113010284998600_B121","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1161\/CIRCULATIONAHA.104.503706","article-title":"Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias","volume":"111","author":"Ouvrard-Pascaud","year":"2005","journal-title":"Circulation"},{"key":"2021113010284998600_B122","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.CIR.0000138973.55605.38","article-title":"Mineralocorticoid receptor antagonism prevents the electrical remodeling that precedes cellular hypertrophy after myocardial infarction","volume":"110","author":"Perrier","year":"2004","journal-title":"Circulation"},{"key":"2021113010284998600_B123","doi-asserted-by":"crossref","first-page":"H310","DOI":"10.1152\/ajpheart.01137.2009","article-title":"Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model","volume":"299","author":"Stein","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"2021113010284998600_B124","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/01.RES.85.12.1139","article-title":"Aldosterone upregulates Ca2+ current in adult rat cardiomyocytes","volume":"85","author":"Benitah","year":"1999","journal-title":"Circ. Res."},{"key":"2021113010284998600_B125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-7793.2001.0151k.x","article-title":"Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes","volume":"537","author":"Benitah","year":"2001","journal-title":"J. Physiol."},{"key":"2021113010284998600_B126","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00424-008-0518-1","article-title":"Aldosterone-induced changes in the cardiac L-type Ca2+ current can be prevented by antioxidants in\u00a0vitro and are absent in rats on low salt diet","volume":"457","author":"Wagner","year":"2008","journal-title":"Pflugers Arch."},{"key":"2021113010284998600_B127","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00424-007-0387-z","article-title":"Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes","volume":"456","author":"Rougier","year":"2008","journal-title":"Pflugers Arch."},{"key":"2021113010284998600_B128","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cardiores.2005.05.009","article-title":"Aldosterone increases T-type calcium channel expression and in\u00a0vitro beating frequency in neonatal rat cardiomyocytes","volume":"67","author":"Lalevee","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"2021113010284998600_B129","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/cvr\/cvq087","article-title":"Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency","volume":"87","author":"Le Menuet","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"2021113010284998600_B130","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/cs0950687","article-title":"Aldosterone blunts the baroreflex response in man","volume":"95","author":"Yee","year":"1998","journal-title":"Clin. Sci."},{"key":"2021113010284998600_B131","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/ar.21081","article-title":"Chronic heart rate reduction facilitates cardiomyocyte survival after myocardial infarction","volume":"293","author":"Zhang","year":"2010","journal-title":"Anat. Rec."},{"key":"2021113010284998600_B132","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2885.2009.01122.x","article-title":"Aldosterone receptor antagonists: how cardiovascular actions may explain their beneficial effects in heart failure","volume":"33","author":"Ovaert","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"2021113010284998600_B133","doi-asserted-by":"crossref","first-page":"H555","DOI":"10.1152\/ajpheart.00847.2010","article-title":"Central interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension","volume":"300","author":"Xue","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010284998600_B134","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00395-009-0059-6","article-title":"Aldosterone improves contractile function of adult rat ventricular cardiomyocytes in a non-acute way: potential relationship to the calcium paradox of aldosteronism","volume":"105","author":"Wenzel","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"2021113010284998600_B135","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1139\/Y07-017","article-title":"Non-genomic effects of aldosterone on intracellular ion regulation and cell volume in rat ventricular myocytes","volume":"85","author":"Matsui","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2021113010284998600_B136","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/HYPERTENSIONAHA.109.136242","article-title":"Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction","volume":"54","author":"Mihailidou","year":"2009","journal-title":"Hypertension"},{"key":"2021113010284998600_B137","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.HYP.0000025879.29822.24","article-title":"Rapid effects of aldosterone and spironolactone in the isolated working rat heart","volume":"40","author":"Barbato","year":"2002","journal-title":"Hypertension"},{"key":"2021113010284998600_B138","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/01.HYP.0000144466.11568.7e","article-title":"Mechanisms for aldosterone and spironolactone-induced positive inotropic actions in the rat heart","volume":"44","author":"Barbato","year":"2004","journal-title":"Hypertension"},{"key":"2021113010284998600_B139","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/cvr\/cvq379","article-title":"T-type Ca2+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes","volume":"90","author":"Ferron","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2021113010284998600_B140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.yjmcc.2012.05.006","article-title":"T-type Ca2+ signalling downregulates MEK1\/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes","volume":"53","author":"Ruchon","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021113010284998600_B141","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.regpep.2008.06.003","article-title":"Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system","volume":"151","author":"De Mello","year":"2008","journal-title":"Regul. Pept."},{"key":"2021113010284998600_B142","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.HYP.0000205831.39339.a5","article-title":"Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?","volume":"47","author":"Chai","year":"2006","journal-title":"Hypertension"},{"key":"2021113010284998600_B143","doi-asserted-by":"crossref","first-page":"H971","DOI":"10.1152\/ajpheart.00374.2004","article-title":"Ischemic preconditioning protects by activating prosurvival kinases at reperfusion","volume":"288","author":"Hausenloy","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010284998600_B144","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/eurheartj\/ehp555","article-title":"Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion","volume":"31","author":"Schmidt","year":"2010","journal-title":"Eur. Heart J."},{"key":"2021113010284998600_B145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1752-8062.2009.00094.x","article-title":"Sex-specific impact of aldosterone receptor antagonism on ventricular remodeling and gene expression after myocardial infarction","volume":"2","author":"Kanashiro-Takeuchi","year":"2009","journal-title":"Clin. Transl. Sci."},{"key":"2021113010284998600_B146","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"key":"2021113010284998600_B147","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2174\/138161211795656891","article-title":"Gender specific aspects of cell death in the cardiovascular system","volume":"17","author":"Pierdominici","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"2021113010284998600_B148","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.CIR.0000135599.33787.CA","article-title":"Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways","volume":"110","author":"Mano","year":"2004","journal-title":"Circulation"},{"key":"2021113010284998600_B149","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/HYPERTENSIONAHA.111.190488","article-title":"Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction","volume":"59","author":"Loan Le","year":"2012","journal-title":"Hypertension"},{"key":"2021113010284998600_B150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1291\/hypres.31.363","article-title":"Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis","volume":"31","author":"Hayashi","year":"2008","journal-title":"Hypertens. Res."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/125\/9\/409\/442567\/cs1250409.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/125\/9\/409\/442567\/cs1250409.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:10:08Z","timestamp":1638270608000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/125\/9\/409\/69154\/Mineralocorticoid-receptors-and-the-heart-multiple"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":150,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20130050","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}