{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:21:13Z","timestamp":1773148873835,"version":"3.50.1"},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:p>PCOS (polycystic ovary syndrome) is associated with IR (insulin resistance), increased visceral fat and NAFLD (non-alcoholic fatty liver disease) all of which may contribute to endothelial dysfunction, an early marker of CVD (cardiovascular disease) risk. Our objective was to examine the relationships between endothelial dysfunction in PCOS, the volume of AT (adipose tissue) compartments and the size of intracellular TAG (triacylglycerol) pools in liver and skeletal muscle. A total of 19 women with PCOS (means\u00b1S.D.; 26\u00b16\u00a0years, 36\u00b15\u00a0kg\/m2) and 16 control women (31\u00b18\u00a0years, 30\u00b16\u00a0kg\/m2) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT (subcutaneous AT) volume were determined by whole body MRI, and liver and skeletal muscle TAG by 1H-MRS (proton magnetic resonance spectroscopy). Cardiorespiratory fitness and HOMA-IR (homoeostasis model assessment of IR) were also determined. Differences between groups were analysed using independent Student's t tests and ANCOVA (analysis of co-variance). FMD was impaired in PCOS by 4.6% [95% CI (confidence interval), 3.0\u20137.7; P&amp;lt;0.001], and this difference decreased only slightly to 4.2% (95% CI, 2.4\u20136.1; P&amp;lt;0.001) when FMD was adjusted for individual differences in visceral and SAT and HOMA-IR. This magnitude of impairment was also similar in lean and obese PCOS women. The results suggest that endothelial dysfunction in PCOS is not explained by body fat distribution or volume. FMD might be a useful independent prognostic tool to assess CVD risk in this population.<\/jats:p>","DOI":"10.1042\/cs20130186","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T08:22:47Z","timestamp":1373271767000},"page":"67-74","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition"],"prefix":"10.1042","volume":"126","author":[{"given":"Victoria\u00a0S.","family":"Sprung","sequence":"first","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher\u00a0J. A.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U.K."},{"name":"School of Sports Science, Exercise and Health, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil\u00a0F.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Liverpool Women's Hospital, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Daousi","sequence":"additional","affiliation":[{"name":"Department of Obesity and Endocrinology, University of Liverpool, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham\u00a0J.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Magnetic Resonance and Image Analysis Research Centre (MARIARC), University of Liverpool, Liverpool, U.K."},{"name":"Department of Musculoskeletal Biology, University of Liverpool, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0J.","family":"Green","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U.K."},{"name":"School of Sports Science, Exercise and Health, University of Western Australia, Crawley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.\u00a0Timothy","family":"Cable","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0J.","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"Department of Obesity and Endocrinology, University of Liverpool, Liverpool, U.K."},{"name":"Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"2021113010303952600_B1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2010.217","article-title":"Polycystic ovary syndrome: etiology, pathogenesis and diagnosis","volume":"7","author":"Goodarzi","year":"2011","journal-title":"Nat. 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