{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:00:35Z","timestamp":1791064835029,"version":"4.1.0"},"reference-count":46,"publisher":"Portland Press Ltd.","issue":"11","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p>Obesity increases linearly with age and is associated with impaired vascular endothelial function and increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to impaired vascular endothelial function in cardiovascular disease; however, their role in uncomplicated human obesity is unknown. Because plasma aldosterone levels are elevated in obesity and adipocytes may be a source of aldosterone, we hypothesized that MRs modulate vascular endothelial function in older adults in an adiposity-dependent manner. To test this hypothesis, we administered MR blockade (eplerenone; 100\u00a0mg\/day) for 1 month in a balanced randomized double-blind placebo-controlled cross-over study to 22 older adults (ten men, 55\u201379\u00a0years) varying widely in adiposity [BMI (body mass index): 20\u201345\u00a0kg\/m2], but who were free from overt cardiovascular disease. We evaluated vascular endothelial function [brachial artery FMD (flow-mediated dilation)] via ultrasonography) and oxidative stress (plasma F2-isoprostanes and vascular endothelial cell protein expression of nitrotyrosine and NADPH oxidase p47phox) during placebo and MR blockade. In the whole group, oxidative stress (P&amp;gt;0.05) and FMD did not change with MR blockade (6.39\u00b10.67 compared with 6.23\u00b10.73%; P=0.7). However, individual improvements in FMD in response to eplerenone were associated with higher total body fat (BMI: r=0.45, P=0.02; and dual-energy X-ray absorptiometry-derived percentage body fat: r=0.50, P=0.009) and abdominal fat (total: r=0.61, P=0.005; visceral: r=0.67, P=0.002; and subcutaneous: r=0.48, P=0.03). In addition, greater improvements in FMD with eplerenone were related to higher baseline fasting glucose (r=0.53, P=0.01). MRs influence vascular endothelial function in an adiposity-dependent manner in healthy older adults.<\/jats:p>","DOI":"10.1042\/cs20130200","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T08:50:14Z","timestamp":1371804614000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Mineralocorticoid receptors modulate vascular endothelial function in human obesity"],"prefix":"10.1042","volume":"125","author":[{"given":"Moon-Hyon","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeung-Ki","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Luttrell","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology, Texas A&M University, College Station, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Kyul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u00a0H.","family":"Meade","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Scott & White Healthcare, Texas A&M University, College Station, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"English","sequence":"additional","affiliation":[{"name":"Department of Family & Community Medicine, Scott & White Healthcare, Texas A&M University Health Science Center, Bryan, TX, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0S.","family":"Segal","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Florida, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetra\u00a0D.","family":"Christou","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"2021113010265662800_B1","volume-title":"Obesity and overweight fact, Fact Sheet No. 311","author":"World Health Organization","year":"2013"},{"key":"2021113010265662800_B2","first-page":"1","article-title":"Prevalence of obesity in the United States, 2009\u20132010","author":"Ogden","year":"2012","journal-title":"NCHS Data Brief"},{"key":"2021113010265662800_B3","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.106.171016","article-title":"Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism","volume":"113","author":"Poirier","year":"2006","journal-title":"Circulation"},{"key":"2021113010265662800_B4","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.jacc.2011.04.049","article-title":"Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. 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