{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:31:36Z","timestamp":1787628696379,"version":"build-2736575974"},"reference-count":41,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>Mental clouding is an almost universal complaint among patients with postural tachycardia syndrome (POTS) but remains poorly understood. Thus, we have determined whether POTS patients exhibit deficits during neuropsychological testing relative to healthy subjects. A comprehensive battery of validated neuropsychological tests was administered to 28 female POTS patients and 24 healthy subjects in a semi-recumbent position. Healthy subjects were matched to POTS patients on age and gender. Selective attention, a primary outcome measure, and cognitive processing speed were reduced in POTS patients compared with healthy subjects (Ruff 2&amp;7 Speed t-score: 40\u00b19 compared with 49\u00b18; P=0.009; Symbol Digit Modalities Test t-score: 45\u00b112 compared with 51\u00b18; P=0.011). Measures of executive function were also lower in POTS patients (Trails B t-score: 46\u00b18 compared with 52\u00b18; P=0.007; Stroop Word Color t-score: 45\u00b110 compared with 56\u00b18; P=0.001), suggesting difficulties in tracking and mental flexibility. Measures of sustained attention, psychomotor speed, memory function or verbal fluency were not significantly different between groups. The present study provides evidence for deficits in selective attention and cognitive processing in patients with POTS, in the seated position when orthostatic stress is minimized. In contrast, other measures of cognitive function, including memory assessments, were not impaired in these patients, suggesting selectivity in these deficits. These findings provide new insight into the profile of cognitive dysfunction in POTS and provide the basis for further studies to identify clinical strategies to better manage the mental clouding associated with this condition.<\/jats:p>","DOI":"10.1042\/cs20140251","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T12:38:31Z","timestamp":1405514311000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Cognitive dysfunction in postural tachycardia syndrome"],"prefix":"10.1042","volume":"128","author":[{"given":"Amy\u00a0C.","family":"Arnold","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Haman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily\u00a0M.","family":"Garland","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William\u00a0D.","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Biaggioni","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Robertson","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."},{"name":"Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish\u00a0R.","family":"Raj","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."},{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"2021113010335744600_B1","first-page":"S19","article-title":"Postural tachycardia syndrome (POTS)","volume":"45","author":"Low","year":"1995","journal-title":"Neurology"},{"key":"2021113010335744600_B2","first-page":"84","article-title":"The Postural Tachycardia Syndrome (POTS): pathophysiology, diagnosis & management","volume":"6","author":"Raj","year":"2006","journal-title":"Indian Pacing Electrophysiol. 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