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Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the skeletal system, by manipulating extracellular signalling molecules involved therein by acting as a hub through a web. However, on the other hand, CCN2 occasionally plays profound roles in major human biological disorders, including fibrosis and malignancies in major organs and tissues, by modulating the actions of key molecules involved in these clinical entities. In this review, the physiological and pathological roles of this unique protein are comprehensively summarized from a molecular network-based viewpoint of CCN2 functionalities.<\/jats:p>","DOI":"10.1042\/cs20140264","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T09:17:23Z","timestamp":1412327843000},"page":"181-196","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Cellular and molecular actions of CCN2\/CTGF and its role under physiological and pathological conditions"],"prefix":"10.1042","volume":"128","author":[{"given":"Satoshi","family":"Kubota","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2014,10,3]]},"reference":[{"key":"2021113010345403200_B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s12079-011-0123-5","article-title":"The role of CCN2\u00a0in cartilage and bone development","volume":"5","author":"Kubota","year":"2011","journal-title":"J. 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