{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:30:46Z","timestamp":1790425846503,"version":"4.1.0"},"reference-count":58,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:p>The rupture of an atherosclerotic plaque is one of the main causes of coronary artery thrombotic occlusion, leading to myocardial infarction. However, the exact mechanism and causal risk factors for plaque rupture remain unclear. To identify a potential molecule that can influence atherosclerotic plaque rupture, we investigated protein expression in serum from patients with acute myocardial infarction (AMI) and stable angina (SA), using proteomic analysis. The expression of six proteins, including fibrinogen, fetuin-B, keratin 9, proapolipoprotein and fibrinogen, were altered in serum from patients with AMI compared with serum from those with SA. Of these, fetuin-B, proapolipoprotein, fibrinogen \u03b3-B-chain precursors and fibrinogen expression were greater in serum from patients with AMI than from patients with SA. Increased fetuin-B expression in serum from AMI patients was also confirmed by Western blot analysis. Treatment with recombinant human fetuin-B increased the migration in monocytes and macrophages in a concentration-dependent manner. Fetuin-B also affected vascular plaque-stabilizing factors, including lipid deposition and cytokine production in macrophages, the activation of matrix metalloproteinase (MMP)-2\u00a0in monocytes, and the activation of apoptosis and MMP-2\u00a0in vascular smooth muscle cells. Moreover, in\u00a0vivo administration of fetuin-B decreased the collagen accumulation and smooth muscle cell content and showed an increased number of macrophages in the vascular plaque. From these results, we suggest that fetuin-B may act as a modulator in the development of AMI. This study may provide a therapeutic advantage for patients at high risk of AMI.<\/jats:p>","DOI":"10.1042\/cs20140462","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T17:04:11Z","timestamp":1423760651000},"page":"27-38","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The serum protein fetuin-B is involved in the development of acute myocardial infarction"],"prefix":"10.1042","volume":"129","author":[{"given":"Seung\u00a0Hyo","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Jong","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u00a0Pa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hye","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan\u00a0Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science, College of Natural Science, Hoseo University, Asan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u00a0Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, Kyungbok University, Pochen, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u00a0Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bokyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,4,1]]},"reference":[{"key":"2021113010390242800_B1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2021113010390242800_B2","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","article-title":"Coronary plaque disruption","volume":"92","author":"Falk","year":"1995","journal-title":"Circulation"},{"key":"2021113010390242800_B3","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1038\/nm1102-1218","article-title":"Innate and acquired immunity in atherogenesis","volume":"8","author":"Binder","year":"2002","journal-title":"Nat. Med."},{"key":"2021113010390242800_B4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1160\/TH11-05-0321","article-title":"Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall","volume":"106","author":"Ketelhuth","year":"2011","journal-title":"Thromb. Haemost."},{"key":"2021113010390242800_B5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0008-6363(98)00286-7","article-title":"Fibrous cap formation or destruction\u2013the critical importance of vascular smooth muscle cell proliferation, migration and matrix formation","volume":"41","author":"Newby","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"2021113010390242800_B6","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1161\/01.ATV.0000178991.71605.18","article-title":"Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage","volume":"25","author":"Virmani","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010390242800_B7","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J. Clin. Invest."},{"key":"2021113010390242800_B8","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1073\/pnas.92.2.402","article-title":"Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases","volume":"92","author":"Galis","year":"1995","journal-title":"Proc. Natl. Acad Sci. U.S.A."},{"key":"2021113010390242800_B9","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1161\/hh2401.101272","article-title":"CD40 signaling and plaque instability","volume":"89","author":"Schonbeck","year":"2001","journal-title":"Circ. Res."},{"key":"2021113010390242800_B10","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1152\/physrev.00005.2003","article-title":"Role of monocytes in atherogenesis","volume":"83","author":"Osterud","year":"2003","journal-title":"Physiol. Rev."},{"key":"2021113010390242800_B11","first-page":"166","article-title":"Atherosclerotic lesions in humans. In situ immunophenotypic analysis suggesting an immune mediated response","volume":"61","author":"van der Wal","year":"1989","journal-title":"Lab. Invest."},{"key":"2021113010390242800_B12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/pmic.200900834","article-title":"3-Morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration","volume":"11","author":"Won","year":"2011","journal-title":"Proteomics"},{"key":"2021113010390242800_B13","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1002\/pmic.200800973","article-title":"Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"2021113010390242800_B14","doi-asserted-by":"publisher","first-page":"6455","DOI":"10.1002\/pmic.200600124","article-title":"Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle","volume":"6","author":"Lee","year":"2006","journal-title":"Proteomics"},{"key":"2021113010390242800_B15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.cbpa.2009.10.008","article-title":"The promise and challenge of \u2018-omic\u2019 approaches","volume":"13","author":"MacBeath","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2021113010390242800_B16","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1002\/ar.21198","article-title":"Biomarkers for the prediction of major adverse cardiovascular events in patients with acute coronary syndrome","volume":"293","author":"Zeng","year":"2010","journal-title":"Anat. Rec. (Hoboken)"},{"key":"2021113010390242800_B17","doi-asserted-by":"publisher","first-page":"4420","DOI":"10.1021\/pr1002017","article-title":"Analysis of the plasma proteome associated with acute coronary syndrome: does a permanent protein signature exist in the plasma of ACS patients?","volume":"9","author":"Dard\u00e9","year":"2010","journal-title":"J. Proteome Res."},{"key":"2021113010390242800_B18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.atherosclerosis.2012.02.024","article-title":"Differential proteomic distribution of TTR (pre-albumin) forms in serum and HDL of patients with high cardiovascular risk","volume":"222","author":"Cubedo","year":"2012","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B19","doi-asserted-by":"publisher","first-page":"920763","DOI":"10.1155\/2011\/920763","article-title":"Quantitative proteomics analysis by isobaric tags for relative and absolute quantitation identified Lumican as a potential marker for acute aortic dissection","volume":"2011","author":"Gu","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"2021113010390242800_B20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-1-60327-210-0","article-title":"Multi-component immunoaffinity subtraction and reversed-phase chromatography of human serum","volume":"425","author":"Martosella","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"2021113010390242800_B21","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2006.08.052","article-title":"Association of high alpha2-Heremans-Schmid glycoprotein\/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass","volume":"195","author":"Fiore","year":"2007","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1042\/BJ20030676","article-title":"Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A","volume":"376","author":"Denecke","year":"2003","journal-title":"Biochem. J."},{"key":"2021113010390242800_B23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0889-1591(03)00054-0","article-title":"Acute stress evokes selective mobilization of T cells that differ in chemokine receptor expression: a potential pathway linking immunologic reactivity to cardiovascular disease","volume":"17","author":"Bosch","year":"2003","journal-title":"Brain Behav. Immun."},{"key":"2021113010390242800_B24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.4161\/cam.1.4.5321","article-title":"Role of cell adhesion molecules and immune-cell migration in the initiation, onset and development of atherosclerosis","volume":"1","author":"Chi","year":"2007","journal-title":"Cell Adh. Migr."},{"key":"2021113010390242800_B25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","article-title":"Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion","volume":"75","author":"Galis","year":"1994","journal-title":"Circ. Res."},{"key":"2021113010390242800_B26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/jcb.21042","article-title":"Salvianolic acid B attenuates MMP-2 and MMP-9 expression in\u00a0vivo in apolipoprotein-E-deficient mouse aorta and in\u00a0vitro in LPS-treated human aortic smooth muscle cells","volume":"100","author":"Lin","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"2021113010390242800_B27","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0008-6363(98)00318-6","article-title":"Role of smooth muscle cell death in advanced coronary primary lesions: implications for plaque instability","volume":"41","author":"Bauriedel","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"2021113010390242800_B28","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/cvr\/cvs363","article-title":"DJ-1\/park7 protects against neointimal formation via the inhibition of vascular smooth muscle cell growth","volume":"97","author":"Won","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"2021113010390242800_B29","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1161\/01.ATV.0000219687.71607.f7","article-title":"A simple method of plaque rupture induction in apolipoprotein E-deficient mice","volume":"26","author":"Sasaki","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010390242800_B30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.atherosclerosis.2008.08.025","article-title":"Vascular remodeling in ApoE-deficient mice: diet dependent modulation after carotid ligation","volume":"204","author":"Eschert","year":"2009","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B31","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1056\/NEJM198405033101801","article-title":"Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death","volume":"310","author":"Davies","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"2021113010390242800_B32","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1161\/01.CIR.0000097121.95451.39","article-title":"Intravascular ultrasound assessment of ulcerated ruptured plaques: a comparison of culprit and nonculprit lesions of patients with acute coronary syndromes and lesions in patients without acute coronary syndromes","volume":"108","author":"Fujii","year":"2003","journal-title":"Circulation"},{"key":"2021113010390242800_B33","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0195-668X(02)00618-8","article-title":"Management of acute myocardial infarction in patients presenting with ST-segment elevation. The task force on the management of acute myocardial infarction of the European Society of Cardiology","volume":"24","author":"Van de Werf","year":"2003","journal-title":"Eur. Heart J."},{"key":"2021113010390242800_B34","doi-asserted-by":"publisher","first-page":"19991","DOI":"10.1074\/jbc.M112234200","article-title":"\u03b12-HS glycoprotein\/fetuin, a transforming growth factor-\u03b2\/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling","volume":"277","author":"Szweras","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021113010390242800_B35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00024382-200115030-00004","article-title":"Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan","volume":"15","author":"Ombrellino","year":"2001","journal-title":"Shock"},{"key":"2021113010390242800_B36","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1093\/ndt\/gfh891","article-title":"Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients","volume":"20","author":"Wang","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"2021113010390242800_B37","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1172\/JCI17202","article-title":"The serum protein \u03b12-Heremans-Schmid glycoprotein\/fetuin-A is a systemically acting inhibitor of ectopic calcification","volume":"112","author":"Schafer","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2021113010390242800_B38","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/ndt\/gfk045","article-title":"Study on the relationship of serum fetuin-A concentration with aortic stiffness in patients on dialysis","volume":"21","author":"Hermans","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"2021113010390242800_B39","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: pathobiological mechanisms and clinical implications","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ. Res."},{"key":"2021113010390242800_B40","first-page":"267","article-title":"Plaque morphology in sudden coronary death","volume":"43","author":"Virmani","year":"1998","journal-title":"Cardiologia"},{"key":"2021113010390242800_B41","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1161\/01.ATV.0000133194.94939.42","article-title":"Vascular calcification: mechanisms and clinical ramifications","volume":"24","author":"Abedin","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010390242800_B42","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1161\/01.CIR.103.8.1051","article-title":"The impact of calcification on the biomechanical stability of atherosclerotic plaques","volume":"103","author":"Huang","year":"2001","journal-title":"Circulation"},{"key":"2021113010390242800_B43","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1161\/hq0901.095554","article-title":"Kinlay S. Relationship of clinical presentation and calcification of culprit coronary artery stenoses","volume":"21","author":"Beckman","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010390242800_B44","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.2174\/1568026611208011166","article-title":"Matrix metalloproteinases and vulnerable atheromatous plaque","volume":"12","author":"Toutouzas","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"2021113010390242800_B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00048.2003","article-title":"Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture","volume":"85","author":"Newby","year":"2005","journal-title":"Physiol. Rev."},{"key":"2021113010390242800_B46","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/01.mol.0000245262.48258.b4","article-title":"Do metalloproteinases destabilize vulnerable atherosclerotic plaques?","volume":"17","author":"Newby","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"2021113010390242800_B47","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1161\/01.CIR.91.8.2125","article-title":"Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina","volume":"91","author":"Brown","year":"1995","journal-title":"Circulation"},{"key":"2021113010390242800_B48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2004.10.041","article-title":"Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques","volume":"180","author":"P\u00f6ll\u00e4nen","year":"2005","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B49","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1023\/A:1007037711339","article-title":"Bradykinin and alpha-thrombin increase human umbilical vein endothelial macromolecular permeability by different mechanisms","volume":"24","author":"Ehringer","year":"2000","journal-title":"Inflammation"},{"key":"2021113010390242800_B50","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nrc745","article-title":"New functions for the matrix metalloproteinases in cancer progression","volume":"2","author":"Egeblad","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"2021113010390242800_B51","first-page":"121","article-title":"Increased expression of 72-kd type\u00a0IV collagenase (MMP-2) in human aortic atherosclerotic lesions","volume":"148","author":"Li","year":"1996","journal-title":"Am. J. Pathol."},{"key":"2021113010390242800_B52","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.atherosclerosis.2009.12.006","article-title":"MMP2 genetic variation is associated with measures of fibrous cap thickness: The Atherosclerosis Risk in Communities Carotid MRI Study","volume":"210","author":"Volcik","year":"1990","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B53","doi-asserted-by":"crossref","first-page":"11077","DOI":"10.1016\/S0021-9258(19)38559-X","article-title":"Structure of the human type\u00a0IV collagenase gene","volume":"265","author":"Huhtala","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021113010390242800_B54","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/10623320600780942","article-title":"Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1\u00a0in patients with hypertension","volume":"13","author":"Derosa","year":"2006","journal-title":"Endothelium"},{"key":"2021113010390242800_B55","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.2337\/dc07-0162","article-title":"Matrix metalloproteinase-2 dysregulation in type\u00a01 diabetes","volume":"30","author":"Thrailkill","year":"2007","journal-title":"Diabetes Care"},{"key":"2021113010390242800_B56","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.atherosclerosis.2014.05.955","article-title":"DJ-1 protein regulates CD3+ T cell migration via overexpression of CXCR4 receptor","volume":"235","author":"Jung","year":"2014","journal-title":"Atherosclerosis"},{"key":"2021113010390242800_B57","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","article-title":"Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion","volume":"75","author":"Galis","year":"1994","journal-title":"Circ. Res."},{"key":"2021113010390242800_B58","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.abb.2012.09.007","article-title":"Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase alpha1 via a mitogen-activated protein kinase and c-Jun pathway","volume":"528","author":"Zhang","year":"2012","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/129\/1\/27\/447041\/cs1290027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/129\/1\/27\/447041\/cs1290027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:29:43Z","timestamp":1638271783000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/129\/1\/27\/71284\/The-serum-protein-fetuin-B-is-involved-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20140462","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,1]]}}}