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Recent evidence suggests that both NOX1 and DUOX2 species produce ROS in the gastrointestinal tract as a result of chronic inflammatory stress; cytokine induction (by interferon-\u03b3, tumour necrosis factor \u03b1, and interleukins IL-4 and IL-13) of NOX1 and DUOX2 may contribute to the development of colorectal and pancreatic carcinomas in patients with inflammatory bowel disease and chronic pancreatitis, respectively. NOX4 expression is increased in pre-malignant fibrotic states which may lead to carcinomas of the lung and liver. NOX5 is highly expressed in malignant melanomas, prostate cancer and Barrett's oesophagus-associated adenocarcinomas, and in the last it is related to chronic gastro-oesophageal reflux and inflammation. Over-expression of functional NOX proteins in many tissues helps to explain tissue injury and DNA damage from ROS that accompany pre-malignant conditions, as well as elucidating the potential mechanisms of NOX-related damage that contribute to both the initiation and the progression of a wide range of solid and haematopoietic malignancies.<\/jats:p>","DOI":"10.1042\/cs20140542","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T18:00:50Z","timestamp":1427479250000},"page":"863-875","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["NADPH oxidases and cancer"],"prefix":"10.1042","volume":"128","author":[{"given":"Krishnendu","family":"Roy","sequence":"first","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0L.","family":"Meitzler","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Juhasz","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamo","family":"Lu","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha","family":"Antony","sequence":"additional","affiliation":[{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0H.","family":"Doroshow","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."},{"name":"Developmental Therapeutics Branch of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"2019102601311028300_B1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.canlet.2013.08.014","article-title":"Molecular mechanisms underlying chronic inflammation-associated cancers","volume":"345","author":"Wu","year":"2014","journal-title":"Cancer Lett."},{"key":"2019102601311028300_B2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrc1046","article-title":"Radical causes of cancer","volume":"3","author":"Hussain","year":"2003","journal-title":"Nat. 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