{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:09:33Z","timestamp":1780358973088,"version":"3.54.1"},"reference-count":29,"publisher":"Portland Press Ltd.","issue":"7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:p>The homing ability and secretory function of mesenchymal stem cells (MSCs) are key factors that influence cell involvement in wound repair. These factors are controlled by multilayer regulatory circuitry, including adhesion molecules, core transcription factors (TFs) and certain other regulators. However, the role of adhesion molecules in this regulatory circuitry and their underlying mechanism remain undefined. In the present paper, we demonstrate that an adhesion molecule, junction adhesion molecule A (JAM-A), may function as a key promoter molecule to regulate skin wound healing by MSCs. In in\u00a0vivo experiments, we show that JAM-A up-regulation promoted both MSC homing to full-thickness skin wounds and wound healing-related cytokine secretion by MSCs. In\u00a0vitro experiments also showed that JAM-A promoted MSC proliferation and migration by activating T-cell lymphoma invasion and metastasis 1 (Tiam1). We suggest that JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects. These results may provide insights into a novel and potentially effective approach to improve the efficacy of MSC treatment.<\/jats:p>","DOI":"10.1042\/cs20140735","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T14:04:09Z","timestamp":1432303449000},"page":"575-588","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells"],"prefix":"10.1042","volume":"129","author":[{"given":"Minjuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Second Military Medical University, Shanghai, China"},{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhao","family":"Ji","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdong","family":"Kong","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Fang","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofan","family":"Xia","sequence":"additional","affiliation":[{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"2021113010483395900_B1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.stem.2012.02.003","article-title":"Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration","volume":"10","author":"Park","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2021113010483395900_B2","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1172\/JCI43230","article-title":"CTGF directs fibroblast differentiation from human mesenchymal stem\/stromal cells and defines connective tissue healing in a rodent injury model","volume":"120","author":"Lee","year":"2010","journal-title":"J. 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