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In this review, we focus on the Nox-mediated ROS signalling pathways involved in the regulation of \u2018longevity genes\u2019 and recapitulate their role in age-associated vascular changes and in the development of age-related cardiovascular diseases (CVDs). This review is predicated on burgeoning knowledge that Nox-derived ROS propagate tightly regulated yet varied signalling pathways, which, at the cellular level, may lead to diminished repair, the aging process and predisposition to CVDs. In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population.<\/jats:p>","DOI":"10.1042\/cs20150087","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T01:18:32Z","timestamp":1453857512000},"page":"317-335","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?"],"prefix":"10.1042","volume":"130","author":[{"given":"Sanghamitra","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel\u00a0N.","family":"Meijles","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick\u00a0J.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"2021113011064987700_B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1023\/A:1013797722156","article-title":"Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons","volume":"7","author":"Lakatta","year":"2002","journal-title":"Heart Fail. 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