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It is thought that physical activity promotes mitochondrial biogenesis in skeletal muscle through increased expression of genes encoded in both the nuclear and the mitochondrial genome; however, how this process is co-ordinated at the cellular level is poorly understood. Nuclear receptors (NRs) are key signalling proteins capable of integrating environmental factors and mitochondrial function, thereby providing a potential link between exercise and mitochondrial biogenesis. The aim of this review is to highlight the function of NRs in skeletal muscle mitochondrial biogenesis and discuss the therapeutic potential of NRs for the management and treatment of chronic metabolic disease.<\/jats:p>","DOI":"10.1042\/cs20150246","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T02:44:48Z","timestamp":1436928288000},"page":"589-599","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease"],"prefix":"10.1042","volume":"129","author":[{"given":"Joaquin","family":"Perez-Schindler","sequence":"first","affiliation":[{"name":"MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Philp","sequence":"additional","affiliation":[{"name":"MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"2021113010481429000_B1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/511147a","article-title":"Non-communicable diseases: Healthy living needs global governance","volume":"511","author":"Gostin","year":"2014","journal-title":"Nature"},{"key":"2021113010481429000_B2","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1038\/508S50a","article-title":"Public health: society at large","volume":"508","author":"Scully","year":"2014","journal-title":"Nature"},{"key":"2021113010481429000_B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S2213-8587(13)70112-8","article-title":"Diabetes: a 21st century challenge","volume":"2","author":"Zimmet","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2021113010481429000_B4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.cell.2014.11.034","article-title":"Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock","volume":"159","author":"Muoio","year":"2014","journal-title":"Cell"},{"key":"2021113010481429000_B5","doi-asserted-by":"publisher","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc. 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