{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:27:43Z","timestamp":1791275263714,"version":"4.1.0"},"reference-count":203,"publisher":"Portland Press Ltd.","issue":"12","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:p>Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor) receptor. The HGF\/Met pathway has a prominent role in cardiovascular remodelling after tissue injury. The present review provides a synopsis of the cellular and molecular mechanisms underlying the effects of HGF\/Met in the heart and blood vessels. In\u00a0vivo, HGF\/Met function is particularly important for the protection of the heart in response to both acute and chronic insults, including ischaemic injury and doxorubicin-induced cardiotoxicity. Accordingly, conditional deletion of Met in cardiomyocytes results in impaired organ defence against oxidative stress. After ischaemic injury, activation of Met provides strong anti-apoptotic stimuli for cardiomyocytes through PI3K (phosphoinositide 3-kinase)\/Akt and MAPK (mitogen-activated protein kinase) cascades. Recently, we found that HGF\/Met is also important for autophagy regulation in cardiomyocytes via the mTOR (mammalian target of rapamycin) pathway. HGF\/Met induces proliferation and migration of endothelial cells through Rac1 (Ras-related C3 botulinum toxin substrate 1) activation. In fibroblasts, HGF\/Met antagonizes the actions of TGF\u03b21 (transforming growth factor \u03b21) and AngII (angiotensin II), thus preventing fibrosis. Moreover, HGF\/Met influences the inflammatory response of macrophages and the immune response of dendritic cells, indicating its protective function against atherosclerotic and autoimmune diseases. The HGF\/Met axis also plays an important role in regulating self-renewal and myocardial regeneration through the enhancement of cardiac progenitor cells. HGF\/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellular and molecular mechanisms underlying repair function in the heart and blood vessels are common and include pro-angiogenic, anti-inflammatory and anti-fibrotic actions. Thus administration of HGF or HGF mimetics may represent a promising therapeutic agent for the treatment of both coronary and peripheral artery disease.<\/jats:p>","DOI":"10.1042\/cs20150502","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T01:48:34Z","timestamp":1447292914000},"page":"1173-1193","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Cellular and molecular mechanisms of HGF\/Met in the cardiovascular system"],"prefix":"10.1042","volume":"129","author":[{"given":"Simona","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Oncology, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Sala","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Turin, Turin, Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gatti","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Crepaldi","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"2021113010564217500_B1","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/0006-291X(84)91253-1","article-title":"Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113010564217500_B2","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1083\/jcb.111.5.2097","article-title":"Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells","volume":"111","author":"Weidner","year":"1990","journal-title":"J. Cell Biol."},{"key":"2021113010564217500_B3","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.1846706","article-title":"Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product","volume":"251","author":"Bottaro","year":"1991","journal-title":"Science"},{"key":"2021113010564217500_B4","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/j.1460-2075.1991.tb07836.x","article-title":"Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor","volume":"10","author":"Naldini","year":"1991","journal-title":"EMBO J."},{"key":"2021113010564217500_B5","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nrm1261","article-title":"Met, metastasis, motility and more","volume":"4","author":"Birchmeier","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021113010564217500_B6","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nrm3012","article-title":"MET signalling: principles and functions in development, organ regeneration and cancer","volume":"11","author":"Trusolino","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021113010564217500_B7","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1007\/s00018-011-0633-6","article-title":"Novel therapy for myocardial infarction: can HGF\/Met be beneficial?","volume":"68","author":"Sala","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"2021113010564217500_B8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3390\/biomedicines2040247","article-title":"HGF\/Met axis in heart function and cardioprotection","volume":"2","author":"Gallo","year":"2014","journal-title":"Biomedicines"},{"key":"2021113010564217500_B9","doi-asserted-by":"crossref","first-page":"9165","DOI":"10.1016\/S0021-9258(18)98327-4","article-title":"Hepatocyte growth factor\/scatter factor stimulates the Ras-guanine nucleotide exchanger","volume":"268","author":"Graziani","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B10","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1172\/JCI30651","article-title":"Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1\/ErbB signaling","volume":"117","author":"Nakaoka","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2021113010564217500_B11","doi-asserted-by":"publisher","first-page":"938","DOI":"10.2119\/molmed.2011.00512","article-title":"Signaling to cardiac hypertrophy: insights from human and mouse RASopathies","volume":"18","author":"Sala","year":"2012","journal-title":"Mol. Med."},{"key":"2021113010564217500_B12","doi-asserted-by":"publisher","first-page":"ra67","DOI":"10.1126\/scisignal.2003948","article-title":"Interference with Akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress","volume":"6","author":"Kerr","year":"2013","journal-title":"Sci. Signal."},{"key":"2021113010564217500_B13","doi-asserted-by":"publisher","first-page":"26445","DOI":"10.1074\/jbc.M314254200","article-title":"Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor","volume":"279","author":"Hashigasako","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B14","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S1097-2765(01)00378-1","article-title":"Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein","volume":"8","author":"Peschard","year":"2001","journal-title":"Mol. Cell"},{"key":"2021113010564217500_B15","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.3390\/cancers6041890","article-title":"Mechanisms of hepatocyte growth factor activation in cancer tissues","volume":"6","author":"Kawaguchi","year":"2014","journal-title":"Cancers (Basel)"},{"key":"2021113010564217500_B16","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1161\/01.RES.78.6.1028","article-title":"Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis","volume":"78","author":"Rappolee","year":"1996","journal-title":"Circ. Res."},{"key":"2021113010564217500_B17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/(SICI)1097-0177(199901)214:1&lt;92::AID-DVDY9&gt;3.0.CO;2-X","article-title":"Hepatocyte growth factor expression in the developing myocardium: evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression","volume":"214","author":"Song","year":"1999","journal-title":"Dev. Dyn."},{"key":"2021113010564217500_B18","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s11248-012-9667-2","article-title":"Gene expression profiling of HGF\/Met activation in neonatal mouse heart","volume":"22","author":"Gatti","year":"2013","journal-title":"Transgenic Res."},{"key":"2021113010564217500_B19","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1006\/bbrc.1996.0606","article-title":"Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction","volume":"221","author":"Matsumori","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113010564217500_B20","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1161\/01.CIR.95.11.2552","article-title":"Enhanced expression of hepatocyte growth factor\/c-Met by myocardial ischemia and reperfusion in a rat model","volume":"95","author":"Ono","year":"1997","journal-title":"Circulation"},{"key":"2021113010564217500_B21","doi-asserted-by":"publisher","first-page":"e14675","DOI":"10.1371\/journal.pone.0014675","article-title":"Activated Met signalling in the developing mouse heart leads to cardiac disease","volume":"6","author":"Leo","year":"2011","journal-title":"PLoS One"},{"key":"2021113010564217500_B22","doi-asserted-by":"publisher","first-page":"e1185","DOI":"10.1038\/cddis.2014.155","article-title":"Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagy","volume":"5","author":"Gallo","year":"2014","journal-title":"Cell Death Dis"},{"key":"2021113010564217500_B23","first-page":"F624","article-title":"Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms","volume":"277","author":"Liu","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2021113010564217500_B24","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1074\/jbc.M211616200","article-title":"Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells","volume":"278","author":"Kitta","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B25","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1161\/CIRCRESAHA.107.164749","article-title":"Activation of Notch-mediated protective signaling in the myocardium","volume":"102","author":"Gude","year":"2008","journal-title":"Circ. Res."},{"key":"2021113010564217500_B26","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.devcel.2012.01.014","article-title":"Coordinating tissue interactions: Notch signaling in cardiac development and disease","volume":"22","author":"de la Pompa","year":"2012","journal-title":"Dev. Cell"},{"key":"2021113010564217500_B27","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.cell.2005.07.002","article-title":"Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy","volume":"122","author":"Pattingre","year":"2005","journal-title":"Cell"},{"key":"2021113010564217500_B28","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1038\/sj.onc.1202722","article-title":"Bcl-2\/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2\/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability","volume":"18","author":"Imazu","year":"1999","journal-title":"Oncogene"},{"key":"2021113010564217500_B29","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.bbadis.2013.08.008","article-title":"Met signaling in cardiomyocytes is required for normal cardiac function in adult mice","volume":"1832","author":"Arechederra","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2021113010564217500_B30","doi-asserted-by":"publisher","first-page":"14581","DOI":"10.1074\/jbc.M707733200","article-title":"Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis","volume":"283","author":"Gomez-Quiroz","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B31","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1172\/JCI27236","article-title":"Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype","volume":"116","author":"Kaposi-Novak","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2021113010564217500_B32","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nrd2530","article-title":"Drug development of MET inhibitors: targeting oncogene addiction and expedience","volume":"7","author":"Comoglio","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021113010564217500_B33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.taap.2013.04.027","article-title":"Multi-parameter in\u00a0vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes","volume":"272","author":"Doherty","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021113010564217500_B34","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1177\/0192623310364027","article-title":"Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor","volume":"38","author":"Aguirre","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"2021113010564217500_B35","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1083\/jcb.119.3.629","article-title":"Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth","volume":"119","author":"Bussolino","year":"1992","journal-title":"J. Cell Biol."},{"key":"2021113010564217500_B36","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1073\/pnas.90.5.1937","article-title":"Scatter factor induces blood vessel formation in\u00a0vivo","volume":"90","author":"Grant","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010564217500_B37","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1182\/blood-2002-06-1731","article-title":"HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in\u00a0vitro","volume":"101","author":"Ding","year":"2003","journal-title":"Blood"},{"key":"2021113010564217500_B38","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1097\/00004872-200018100-00008","article-title":"Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells","volume":"18","author":"Nakagami","year":"2000","journal-title":"J. Hypertens."},{"key":"2021113010564217500_B39","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1097\/00004872-200111000-00007","article-title":"Association between carotid arterial remodeling and plasma concentration of circulating hepatocyte growth factor","volume":"19","author":"Yamamoto","year":"2001","journal-title":"J. Hypertens."},{"key":"2021113010564217500_B40","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1161\/01.HYP.37.2.581","article-title":"Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells","volume":"37","author":"Nakagami","year":"2001","journal-title":"Hypertension"},{"key":"2021113010564217500_B41","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1161\/01.CIR.97.4.381","article-title":"Potentiated angiogenic effect of scatter factor\/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis","volume":"97","author":"Belle","year":"1998","journal-title":"Circulation"},{"key":"2021113010564217500_B42","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/S0962-8924(03)00104-1","article-title":"How to make tubes: signaling by the Met receptor tyrosine kinase","volume":"13","author":"Rosario","year":"2003","journal-title":"Trends Cell Biol."},{"key":"2021113010564217500_B43","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/sj.bjp.0705494","article-title":"Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells","volume":"140","author":"Gerritsen","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"2021113010564217500_B44","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nature03987","article-title":"Pathophysiological consequences of VEGF-induced vascular permeability","volume":"437","author":"Weis","year":"2005","journal-title":"Nature"},{"key":"2021113010564217500_B45","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1096\/fj.01-0870com","article-title":"Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3\u03b2","volume":"16","author":"Liu","year":"2002","journal-title":"FASEB J"},{"key":"2021113010564217500_B46","doi-asserted-by":"publisher","first-page":"30643","DOI":"10.1074\/jbc.M702573200","article-title":"CD44 regulates hepatocyte growth factor-mediated vascular integrity: role of c-Met, Tiam1\/Rac1, dynamin 2, and cortactin","volume":"282","author":"Singleton","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1165\/rcmb.2008-0099OC","article-title":"Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF","volume":"40","author":"Birukova","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2021113010564217500_B48","doi-asserted-by":"publisher","first-page":"L452","DOI":"10.1152\/ajplung.00170.2014","article-title":"Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction","volume":"308","author":"Meng","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2021113010564217500_B49","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.1074\/jbc.M114.620377","article-title":"Hepatocyte growth factor-induced Asef\u2013IQGAP1 complex controls cytoskeletal remodeling and endothelial barrier","volume":"290","author":"Tian","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2021113010564217500_B50","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1128\/MCB.00248-14","article-title":"IQGAP1 regulates endothelial barrier function via EB1\u2013cortactin cross talk","volume":"34","author":"Tian","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"2021113010564217500_B51","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/BC20080221","article-title":"Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells","volume":"101","author":"Sulpice","year":"2009","journal-title":"Biol. Cell"},{"key":"2021113010564217500_B52","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1182\/blood-2007-04-084269","article-title":"Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity","volume":"111","author":"Sulpice","year":"2008","journal-title":"Blood"},{"key":"2021113010564217500_B53","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1161\/HYPERTENSIONAHA.108.120725","article-title":"Hepatocyte growth factor, but not vascular endothelial growth factor, attenuates angiotensin II-induced endothelial progenitor cell senescence","volume":"53","author":"Sanada","year":"2009","journal-title":"Hypertension"},{"key":"2021113010564217500_B54","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.yjmcc.2004.09.004","article-title":"Hepatocyte growth factor prevents ventricular remodeling and dysfunction in mice via Akt pathway and angiogenesis","volume":"37","author":"Wang","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B55","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/sj.gt.3301104","article-title":"Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets","volume":"7","author":"Aoki","year":"2000","journal-title":"Gene Ther."},{"key":"2021113010564217500_B56","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s11248-011-9485-y","article-title":"A mouse model for spatial and temporal expression of HGF in the heart","volume":"20","author":"Riess","year":"2011","journal-title":"Transgenic Res."},{"key":"2021113010564217500_B57","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1161\/01.HYP.33.6.1379","article-title":"Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy","volume":"33","author":"Morishita","year":"1999","journal-title":"Hypertension"},{"key":"2021113010564217500_B58","doi-asserted-by":"publisher","first-page":"II301","DOI":"10.1161\/01.CIR.100.suppl_2.II-301","article-title":"Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: downregulation of HGF in response to hypoxia in vascular cells","volume":"100","author":"Hayashi","year":"1999","journal-title":"Circulation"},{"key":"2021113010564217500_B59","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1182\/blood-2005-09-012807","article-title":"Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment","volume":"108","author":"Kobayashi","year":"2006","journal-title":"Blood"},{"key":"2021113010564217500_B60","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1161\/ATVBAHA.112.300041","article-title":"Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation","volume":"32","author":"Shimizu","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010564217500_B61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1677\/joe.0.1750217","article-title":"Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue","volume":"175","author":"Matsumoto","year":"2002","journal-title":"J. Endocrinol."},{"key":"2021113010564217500_B62","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s003800300003","article-title":"Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats","volume":"18","author":"Matsumoto","year":"2003","journal-title":"Heart Vessels"},{"key":"2021113010564217500_B63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00041552-199301000-00004","article-title":"The role of mechanical and humoral factors in growth regulation of vascular smooth muscle and cardiac myocytes","volume":"2","author":"Dzau","year":"1993","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"2021113010564217500_B64","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/S0006-291X(02)02397-5","article-title":"Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration","volume":"298","author":"Taher","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113010564217500_B65","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2353\/ajpath.2006.050379","article-title":"Hepatocyte growth factor\/scatter factor and MET are involved in arterial repair and atherogenesis","volume":"168","author":"McKinnon","year":"2006","journal-title":"Am. J. Pathol."},{"key":"2021113010564217500_B66","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2011.08.033","article-title":"HGF\/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in\u00a0vitro","volume":"219","author":"Liu","year":"2011","journal-title":"Atherosclerosis"},{"key":"2021113010564217500_B67","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1006\/jmcc.1997.0435","article-title":"Angiotensin II stimulated expression of transforming growth factor-\u03b21\u00a0in cardiac fibroblasts and myofibroblasts","volume":"29","author":"Campbell","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B68","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1016\/S0022-2828(95)91983-X","article-title":"Angiotensin II stimulates the autocrine production of transforming growth factor-\u03b21\u00a0in adult rat cardiac fibroblasts","volume":"27","author":"Lee","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B69","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0008-6363(00)00030-4","article-title":"Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis","volume":"46","author":"MacKenna","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"2021113010564217500_B70","first-page":"E426","article-title":"Trophic effects of angiotensin II on neonatal rat cardiac myocytes are mediated by cardiac fibroblasts","volume":"269","author":"Kim","year":"1995","journal-title":"Am. J. Physiol."},{"key":"2021113010564217500_B71","doi-asserted-by":"publisher","first-page":"H2131","DOI":"10.1152\/ajpheart.01239.2003","article-title":"Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts","volume":"288","author":"Nakamura","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113010564217500_B72","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1161\/01.CIR.102.2.246","article-title":"Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters","volume":"102","author":"Taniyama","year":"2000","journal-title":"Circulation"},{"key":"2021113010564217500_B73","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats","volume":"5","author":"Ueki","year":"1999","journal-title":"Nat. Med."},{"key":"2021113010564217500_B74","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1046\/j.1523-1755.2003.00202.x","article-title":"Hepatocyte growth factor regulates proteoglycan synthesis in interstitial fibroblasts","volume":"64","author":"Kobayashi","year":"2003","journal-title":"Kidney Int."},{"key":"2021113010564217500_B75","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1096\/fj.04-1535fje","article-title":"HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis","volume":"19","author":"Mizuno","year":"2005","journal-title":"FASEB J."},{"key":"2021113010564217500_B76","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/sj.gt.3302740","article-title":"Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy","volume":"13","author":"Azuma","year":"2006","journal-title":"Gene Ther."},{"key":"2021113010564217500_B77","doi-asserted-by":"publisher","first-page":"II230","DOI":"10.1161\/01.cir.0000087444.53354.66","article-title":"Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure","volume":"108","author":"Jayasankar","year":"2003","journal-title":"Circulation"},{"key":"2021113010564217500_B78","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.cardfail.2007.07.004","article-title":"In\u00a0vivo hepatocyte growth factor gene transfer reduces myocardial ischemia\u2013reperfusion injury through its multiple actions","volume":"13","author":"Chen","year":"2007","journal-title":"J. Card. Fail."},{"key":"2021113010564217500_B79","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1161\/01.HYP.0000020755.56955.BF","article-title":"Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy","volume":"40","author":"Taniyama","year":"2002","journal-title":"Hypertension"},{"key":"2021113010564217500_B80","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.bbadis.2012.02.012","article-title":"Loss of c-Met accelerates development of liver fibrosis in response to CCl4 exposure through deregulation of multiple molecular pathways","volume":"1822","author":"Marquardt","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"2021113010564217500_B81","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1161\/HYPERTENSIONAHA.111.183905","article-title":"Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial\u2013mesenchymal transition","volume":"59","author":"Okayama","year":"2012","journal-title":"Hypertension"},{"key":"2021113010564217500_B82","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0008-6363(02)00255-9","article-title":"Hepatocyte growth factor-induced endothelial cell motility is mediated by the upregulation of inducible nitric oxide synthase expression","volume":"54","author":"Purdie","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"2021113010564217500_B83","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1161\/01.HYP.30.6.1621","article-title":"Chronic angiotensin-converting enzyme inhibition and angiotensin II type\u00a01 receptor blockade: effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis","volume":"30","author":"Takemoto","year":"1997","journal-title":"Hypertension"},{"key":"2021113010564217500_B84","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1161\/01.HYP.32.2.273","article-title":"Early induction of transforming growth factor-\u03b2 via angiotensin II type\u00a01 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats","volume":"32","author":"Tomita","year":"1998","journal-title":"Hypertension"},{"key":"2021113010564217500_B85","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1182\/blood.V85.11.3093.bloodjournal85113093","article-title":"Hepatocyte growth factor as a hematopoietic regulator","volume":"85","author":"Nishino","year":"1995","journal-title":"Blood"},{"key":"2021113010564217500_B86","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.autrev.2014.11.013","article-title":"Hepatocyte growth factor: a regulator of inflammation and autoimmunity","volume":"14","author":"Molnarfi","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"2021113010564217500_B87","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.4049\/jimmunol.166.2.1241","article-title":"Hepatocyte growth factor is a regulator of monocyte\u2013macrophage function","volume":"166","author":"Galimi","year":"2001","journal-title":"J. Immunol."},{"key":"2021113010564217500_B88","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/glia.20945","article-title":"Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis","volume":"58","author":"Moransard","year":"2010","journal-title":"Glia"},{"key":"2021113010564217500_B89","doi-asserted-by":"publisher","first-page":"6424","DOI":"10.1073\/pnas.0912437107","article-title":"Hepatocyte growth factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25+Foxp3+ regulatory T cells","volume":"107","author":"Benkhoucha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010564217500_B90","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.4049\/jimmunol.175.7.4745","article-title":"A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function","volume":"175","author":"Okunishi","year":"2005","journal-title":"J. Immunol."},{"key":"2021113010564217500_B91","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/1521-4141(200207)32:7&lt;1832::AID-IMMU1832&gt;3.0.CO;2-2","article-title":"The impact of c-met\/scatter factor receptor on dendritic cell migration","volume":"32","author":"Kurz","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2021113010564217500_B92","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nature14407","article-title":"MET is required for the recruitment of anti-tumoural neutrophils","volume":"522","author":"Finisguerra","year":"2015","journal-title":"Nature"},{"key":"2021113010564217500_B93","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1182\/blood.V90.11.4450","article-title":"Neoexpression of the c-met\/hepatocyte growth factor-scatter factor receptor gene in activated monocytes","volume":"90","author":"Beilmann","year":"1997","journal-title":"Blood"},{"key":"2021113010564217500_B94","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1182\/blood.V95.12.3964.012k20_3964_3969","article-title":"Hepatocyte growth factor-stimulated invasiveness of monocytes","volume":"95","author":"Beilmann","year":"2000","journal-title":"Blood"},{"key":"2021113010564217500_B95","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1182\/blood-2005-08-3141","article-title":"Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low\/neg accessory cells with dendritic-cell features","volume":"108","author":"Rutella","year":"2006","journal-title":"Blood"},{"key":"2021113010564217500_B96","doi-asserted-by":"publisher","first-page":"e15384","DOI":"10.1371\/journal.pone.0015384","article-title":"Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases","volume":"5","author":"Coudriet","year":"2010","journal-title":"PLoS One"},{"key":"2021113010564217500_B97","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1161\/01.CIR.101.9.1019","article-title":"Crucial role of endogenous interleukin-10 production in myocardial ischemia\/reperfusion injury","volume":"101","author":"Yang","year":"2000","journal-title":"Circulation"},{"key":"2021113010564217500_B98","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/j.1440-1681.2009.05151.x","article-title":"Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization: a pilot gene therapy study in patients with coronary heart disease","volume":"36","author":"Yang","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2021113010564217500_B99","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1161\/01.RES.85.8.e17","article-title":"Protective role of interleukin-10\u00a0in atherosclerosis","volume":"85","author":"Mallat","year":"1999","journal-title":"Circ. Res."},{"key":"2021113010564217500_B100","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/S0008-6363(00)00287-X","article-title":"Effects of interleukin-10 on monocyte\/endothelial cell adhesion and MMP-9\/TIMP-1 secretion","volume":"49","author":"Mostafa Mtairag","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"2021113010564217500_B101","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1161\/hc3201.094973","article-title":"Serum levels of the antiinflammatory cytokine interleukin-10 are decreased in patients with unstable angina","volume":"104","author":"Smith","year":"2001","journal-title":"Circulation"},{"key":"2021113010564217500_B102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.RES.75.1.1","article-title":"Interleukin-8: a mitogen and chemoattractant for vascular smooth muscle cells","volume":"75","author":"Yue","year":"1994","journal-title":"Circ. Res."},{"key":"2021113010564217500_B103","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/19546","article-title":"MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions","volume":"398","author":"Gerszten","year":"1999","journal-title":"Nature"},{"key":"2021113010564217500_B104","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1042\/bj2990881","article-title":"Immunocomplexes stimulate different signalling events to chemoattractants in the neutrophil and regulate L-selectin and \u03b22-integrin expression differently","volume":"299","author":"Molad","year":"1994","journal-title":"Biochem J."},{"key":"2021113010564217500_B105","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1084\/jem.167.5.1547","article-title":"A novel neutrophil-activating factor produced by human mononuclear phagocytes","volume":"167","author":"Peveri","year":"1988","journal-title":"J. Exp. Med."},{"key":"2021113010564217500_B106","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.atherosclerosis.2011.02.025","article-title":"Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue","volume":"216","author":"Shintani","year":"2011","journal-title":"Atherosclerosis"},{"key":"2021113010564217500_B107","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.biocel.2014.05.032","article-title":"Implication of anti-inflammatory macrophages in regenerative moto-neuritogenesis: promotion of myoblast migration and neural chemorepellent semaphorin 3A expression in injured muscle","volume":"54","author":"Sakaguchi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021113010564217500_B108","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1161\/ATVBAHA.114.304652","article-title":"Monocytes in myocardial infarction","volume":"35","author":"Dutta","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010564217500_B109","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","article-title":"Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors","volume":"8","author":"De Palma","year":"2005","journal-title":"Cancer Cell"},{"key":"2021113010564217500_B110","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1161\/01.RES.0000163016.52653.2e","article-title":"Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines","volume":"96","author":"Futamatsu","year":"2005","journal-title":"Circ. Res."},{"key":"2021113010564217500_B111","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1161\/01.CIR.0000143052.45956.71","article-title":"Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy","volume":"110","author":"Yamaura","year":"2004","journal-title":"Circulation"},{"key":"2021113010564217500_B112","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nn.3109","article-title":"Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models","volume":"15","author":"Bai","year":"2012","journal-title":"Nat. Neurosci."},{"key":"2021113010564217500_B113","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1084\/jem.174.2.493","article-title":"Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction","volume":"174","author":"Dallman","year":"1991","journal-title":"J. Exp. Med."},{"key":"2021113010564217500_B114","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/00007890-200107270-00027","article-title":"A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis","volume":"72","author":"Saiura","year":"2001","journal-title":"Transplantation"},{"key":"2021113010564217500_B115","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1172\/JCI119564","article-title":"Interferon-\u03b3 deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts","volume":"100","author":"Nagano","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2021113010564217500_B116","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.yjmcc.2010.08.005","article-title":"Paracrine mechanisms of stem cell reparative and regenerative actions in the heart","volume":"50","author":"Mirotsou","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B117","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/CIRCRESAHA.109.210682","article-title":"Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice","volume":"106","author":"Chimenti","year":"2010","journal-title":"Circ. Res."},{"key":"2021113010564217500_B118","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/emmm.201201737","article-title":"Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart","volume":"5","author":"Malliaras","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"2021113010564217500_B119","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1634\/stemcells.22-3-405","article-title":"Functional expression of HGF and HGF receptor\/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing","volume":"22","author":"Neuss","year":"2004","journal-title":"Stem Cells"},{"key":"2021113010564217500_B120","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1634\/stemcells.2007-1104","article-title":"Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells","volume":"26","author":"Rosova","year":"2008","journal-title":"Stem Cells"},{"key":"2021113010564217500_B121","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/01.RES.0000183733.53101.11","article-title":"Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival","volume":"97","author":"Urbanek","year":"2005","journal-title":"Circ. Res."},{"key":"2021113010564217500_B122","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1161\/01.CIR.0000058702.69484.A0","article-title":"Peripheral blood \u201cendothelial progenitor cells\u201d are derived from monocyte\/macrophages and secrete angiogenic growth factors","volume":"107","author":"Rehman","year":"2003","journal-title":"Circulation"},{"key":"2021113010564217500_B123","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1084\/jem.20070166","article-title":"Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart","volume":"204","author":"Cho","year":"2007","journal-title":"J. Exp. Med."},{"key":"2021113010564217500_B124","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.yjmcc.2005.07.003","article-title":"Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells","volume":"39","author":"Urbich","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B125","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1634\/stemcells.2007-0388","article-title":"Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization","volume":"25","author":"Cai","year":"2007","journal-title":"Stem Cells"},{"key":"2021113010564217500_B126","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.jacc.2011.05.013","article-title":"Endogenous cardiac stem cell activation by insulin-like growth factor-1\/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart","volume":"58","author":"Ellison","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021113010564217500_B127","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12265-013-9518-4","article-title":"Sustained delivery of insulin-like growth factor-1\/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart","volume":"7","author":"Koudstaal","year":"2014","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"2021113010564217500_B128","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1038\/ncpcardio0409","article-title":"Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration","volume":"3","author":"Torella","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"2021113010564217500_B129","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.pcad.2007.03.005","article-title":"Endogenous cardiac stem cells","volume":"50","author":"Barile","year":"2007","journal-title":"Prog. Cardiovasc. Dis."},{"key":"2021113010564217500_B130","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1161\/CIRCRESAHA.116.303595","article-title":"Origin of cardiomyocytes in the adult heart","volume":"116","author":"Leri","year":"2015","journal-title":"Circ. Res."},{"key":"2021113010564217500_B131","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.cell.2005.01.025","article-title":"Pursuing cardiac progenitors: regeneration redux","volume":"120","author":"Parmacek","year":"2005","journal-title":"Cell"},{"key":"2021113010564217500_B132","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1152\/physrev.00013.2005","article-title":"Cardiac stem cells and mechanisms of myocardial regeneration","volume":"85","author":"Leri","year":"2005","journal-title":"Physiol. Rev."},{"key":"2021113010564217500_B133","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1161\/CIRCULATIONAHA.106.655209","article-title":"Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens","volume":"115","author":"Smith","year":"2007","journal-title":"Circulation"},{"key":"2021113010564217500_B134","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.scr.2014.09.001","article-title":"Cardiac stem cell niches","volume":"13","author":"Leri","year":"2014","journal-title":"Stem Cell Res."},{"key":"2021113010564217500_B135","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fphys.2014.00219","article-title":"Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function","volume":"5","author":"Pagliari","year":"2014","journal-title":"Front. Physiol."},{"key":"2021113010564217500_B136","doi-asserted-by":"publisher","first-page":"15529","DOI":"10.1073\/pnas.0808357105","article-title":"Notch1 regulates the fate of cardiac progenitor cells","volume":"105","author":"Boni","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010564217500_B137","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1002\/hep.24796","article-title":"Hepatocyte growth factor\/c-met signaling is required for stem-cell-mediated liver regeneration in mice","volume":"55","author":"Ishikawa","year":"2012","journal-title":"Hepatology"},{"key":"2021113010564217500_B138","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1083\/jcb.200701086","article-title":"c-Met is essential for wound healing in the skin","volume":"177","author":"Chmielowiec","year":"2007","journal-title":"J. Cell Biol."},{"key":"2021113010564217500_B139","doi-asserted-by":"publisher","first-page":"e81757","DOI":"10.1371\/journal.pone.0081757","article-title":"c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration","volume":"8","author":"Webster","year":"2013","journal-title":"PLoS One"},{"key":"2021113010564217500_B140","doi-asserted-by":"publisher","first-page":"9951","DOI":"10.1073\/pnas.1016912108","article-title":"c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010564217500_B141","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1158\/0008-5472.CAN-11-3490","article-title":"The MET oncogene is a functional marker of a glioblastoma stem cell subtype","volume":"72","author":"De Bacco","year":"2012","journal-title":"Cancer Res."},{"key":"2021113010564217500_B142","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.ccr.2012.03.041","article-title":"Lunatic fringe deficiency cooperates with the Met\/caveolin gene amplicon to induce basal-like breast cancer","volume":"21","author":"Xu","year":"2012","journal-title":"Cancer Cell"},{"key":"2021113010564217500_B143","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/onc.2012.154","article-title":"Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer","volume":"32","author":"Gastaldi","year":"2013","journal-title":"Oncogene"},{"key":"2021113010564217500_B144","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/nature10188","article-title":"De novo cardiomyocytes from within the activated adult heart after injury","volume":"474","author":"Smart","year":"2011","journal-title":"Nature"},{"key":"2021113010564217500_B145","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.yjmcc.2009.11.008","article-title":"Myocardial infarction induces embryonic reprogramming of epicardial c-kit+ cells: role of the pericardial fluid","volume":"48","author":"Limana","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021113010564217500_B146","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/cvr\/cvv168","article-title":"Human epicardial cell-conditioned medium contains HGF\/IgG complexes that phosphorylate RYK and protect against vascular injury","volume":"107","author":"Rao","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"2021113010564217500_B147","doi-asserted-by":"publisher","first-page":"833","DOI":"10.2217\/rme.12.82","article-title":"Stem cell recruitment after injury: lessons for regenerative medicine","volume":"7","author":"Rennert","year":"2012","journal-title":"Regen. Med."},{"key":"2021113010564217500_B148","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1161\/01.RES.0000150856.47324.5b","article-title":"Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction","volume":"95","author":"Kucia","year":"2004","journal-title":"Circ. Res."},{"key":"2021113010564217500_B149","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1634\/stemcells.2005-0271","article-title":"Migration of bone marrow and cord blood mesenchymal stem cells in\u00a0vitro is regulated by stromal-derived factor-1\u2013CXCR4 and hepatocyte growth factor\u2013c-met axes and involves matrix metalloproteinases","volume":"24","author":"Son","year":"2006","journal-title":"Stem Cells"},{"key":"2021113010564217500_B150","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ceb.2014.09.008","article-title":"MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure","volume":"31","author":"Boccaccio","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"2021113010564217500_B151","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrc1912","article-title":"Invasive growth: a MET-driven genetic programme for cancer and stem cells","volume":"6","author":"Boccaccio","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2021113010564217500_B152","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.scr.2014.06.001","article-title":"Signaling through three chemokine receptors triggers the migration of transplanted neural precursor cells in a model of multiple sclerosis","volume":"13","author":"Cohen","year":"2014","journal-title":"Stem Cell Res"},{"key":"2021113010564217500_B153","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1089\/scd.2011.0575","article-title":"Activation of diverse signaling pathways by ex-vivo delivery of multiple cytokines for myocardial repair","volume":"22","author":"Konoplyannikov","year":"2013","journal-title":"Stem Cells Dev."},{"key":"2021113010564217500_B154","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.stem.2014.01.009","article-title":"CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis","volume":"14","author":"Todaro","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2021113010564217500_B155","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.celrep.2013.11.001","article-title":"Combined Wnt\/\u03b2-catenin, Met, and CXCL12\/CXCR4 signals characterize basal breast cancer and predict disease outcome","volume":"5","author":"Holland","year":"2013","journal-title":"Cell Rep."},{"key":"2021113010564217500_B156","doi-asserted-by":"publisher","first-page":"e459","DOI":"10.1038\/cddis.2012.199","article-title":"The decreased metastatic potential of rhabdomyosarcoma cells obtained through MET receptor downregulation and the induction of differentiation","volume":"4","author":"Miekus","year":"2013","journal-title":"Cell Death Dis."},{"key":"2021113010564217500_B157","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.immuni.2015.05.014","article-title":"Hepatocyte growth factor receptor c-Met instructs T cell cardiotropism and promotes T cell migration to the heart via autocrine chemokine release","volume":"42","author":"Komarowska","year":"2015","journal-title":"Immunity"},{"key":"2021113010564217500_B158","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.athoracsur.2004.10.051","article-title":"Control-released hepatocyte growth factor prevents the progression of heart failure in stroke-prone spontaneously hypertensive rats","volume":"79","author":"Sakaguchi","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"2021113010564217500_B159","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.biomaterials.2014.12.021","article-title":"Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction","volume":"45","author":"Sonnenberg","year":"2015","journal-title":"Biomaterials"},{"key":"2021113010564217500_B160","doi-asserted-by":"publisher","first-page":"e50980","DOI":"10.1371\/journal.pone.0050980","article-title":"Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats","volume":"7","author":"Salimath","year":"2012","journal-title":"PLoS One"},{"key":"2021113010564217500_B161","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/icvts\/ivt512","article-title":"Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin","volume":"18","author":"Nakano","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"2021113010564217500_B162","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1016\/j.biomaterials.2010.02.026","article-title":"The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model","volume":"31","author":"Ruvinov","year":"2010","journal-title":"Biomaterials"},{"key":"2021113010564217500_B163","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1067\/mtc.2002.123809","article-title":"Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor","volume":"124","author":"Funatsu","year":"2002","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"2021113010564217500_B164","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/S0003-4975(02)04677-5","article-title":"Gene transfer of hepatocyte growth factor improves angiogenesis and function of chronic ischemic myocardium in canine heart","volume":"75","author":"Ahmet","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"2021113010564217500_B165","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/j.1745-7254.2006.00306.x","article-title":"Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"2021113010564217500_B166","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/gt.2011.128","article-title":"Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model","volume":"19","author":"Jin","year":"2012","journal-title":"Gene Ther."},{"key":"2021113010564217500_B167","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1161\/01.CIR.0000065579.19126.B8","article-title":"Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice","volume":"107","author":"Li","year":"2003","journal-title":"Circulation"},{"key":"2021113010564217500_B168","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1067\/mtc.2002.126655","article-title":"Gene transfection of hepatocyte growth factor attenuates cardiac remodeling in the canine heart: a novel gene therapy for cardiomyopathy","volume":"124","author":"Ahmet","year":"2002","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"2021113010564217500_B169","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/hc4401.098470","article-title":"Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes","volume":"104","author":"Taniyama","year":"2001","journal-title":"Circulation"},{"key":"2021113010564217500_B170","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/ATVBAHA.110.219550","article-title":"Phase I\/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia","volume":"31","author":"Morishita","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010564217500_B171","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1161\/ATVBAHA.111.244632","article-title":"Long-term follow-up evaluation of results from clinical trial using hepatocyte growth factor gene to treat severe peripheral arterial disease","volume":"32","author":"Makino","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010564217500_B172","first-page":"629","article-title":"Short-term safety and curative effect of recombinant adenovirus carrying hepatocyte growth factor gene on ischemic cardiac disease","volume":"22","author":"Yuan","year":"2008","journal-title":"In\u00a0Vivo"},{"key":"2021113010564217500_B173","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s11033-008-9315-3","article-title":"Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease","volume":"36","author":"Yang","year":"2009","journal-title":"Mol. Biol. Rep."},{"key":"2021113010564217500_B174","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.ijcard.2012.06.052","article-title":"MSCs transfected with hepatocyte growth factor or vascular endothelial growth factor improve cardiac function in the infarcted porcine heart by increasing angiogenesis and reducing fibrosis","volume":"167","author":"Lu","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"2021113010564217500_B175","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/cbf.2836","article-title":"Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts","volume":"30","author":"Wang","year":"2012","journal-title":"Cell Biochem. Funct."},{"key":"2021113010564217500_B176","doi-asserted-by":"publisher","first-page":"e111246","DOI":"10.1371\/journal.pone.0111246","article-title":"Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"2021113010564217500_B177","doi-asserted-by":"publisher","first-page":"e93645","DOI":"10.1371\/journal.pone.0093645","article-title":"Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"2021113010564217500_B178","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/jcbfm.2015.23","article-title":"Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice","volume":"35","author":"Chaparro","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2021113010564217500_B179","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1124\/jpet.114.218735","article-title":"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor\/c-met system","volume":"351","author":"Benoist","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021113010564217500_B180","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/jcs.111.2.237","article-title":"Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF","volume":"111","author":"Prat","year":"1998","journal-title":"J. Cell Sci."},{"key":"2021113010564217500_B181","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ahj.2005.03.047","article-title":"Prognostic significance of circulating levels of angiogenic cytokines in patients with congestive heart failure","volume":"150","author":"Lamblin","year":"2005","journal-title":"Am. Heart J."},{"key":"2021113010564217500_B182","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.exger.2013.07.009","article-title":"Vascular cell adhesion molecule 1, soluble Fas and hepatocyte growth factor as predictors of mortality in nonagenarians: the Vitality 90+ study","volume":"48","author":"Kamppa","year":"2013","journal-title":"Exp. Gerontol."},{"key":"2021113010564217500_B183","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1291\/hypres.22.161","article-title":"Hepatocyte growth factor (HGF) as a potential index of severity of hypertension","volume":"22","author":"Morishita","year":"1999","journal-title":"Hypertens. Res."},{"key":"2021113010564217500_B184","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1097\/00004872-199816121-00025","article-title":"Hepatocyte growth factor as a potential index of complication in diabetes mellitus","volume":"16","author":"Nakamura","year":"1998","journal-title":"J. Hypertens."},{"key":"2021113010564217500_B185","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1054\/jcaf.2001.27686","article-title":"Serum hepatocyte growth factor levels are increased in patients with congestive heart failure","volume":"7","author":"Ueno","year":"2001","journal-title":"J. Card. Fail."},{"key":"2021113010564217500_B186","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1136\/hrt.2010.220228","article-title":"Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure","volume":"97","author":"Rychli","year":"2011","journal-title":"Heart"},{"key":"2021113010564217500_B187","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.ijcard.2012.11.052","article-title":"A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure","volume":"168","author":"Richter","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"2021113010564217500_B188","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1006\/bbrc.1997.7800","article-title":"A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension","volume":"242","author":"Nakamura","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113010564217500_B189","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1161\/01.HYP.28.3.409","article-title":"A vascular modulator, hepatocyte growth factor, is associated with systolic pressure","volume":"28","author":"Nakamura","year":"1996","journal-title":"Hypertension"},{"key":"2021113010564217500_B190","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1291\/hypres.25.655","article-title":"Hepatocyte growth factor and 24-hour ambulatory blood pressure monitoring","volume":"25","author":"Hayashi","year":"2002","journal-title":"Hypertens. Res."},{"key":"2021113010564217500_B191","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/03014460701822003","article-title":"Genetic and environmental determinants of hepatocyte growth factor levels and their association with obesity and blood pressure","volume":"35","author":"Vistoropsky","year":"2008","journal-title":"Ann. Hum. Biol."},{"key":"2021113010564217500_B192","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1291\/hypres.25.661","article-title":"Plasma hepatocyte growth factor and the relationship between risk factors and carotid atherosclerosis","volume":"25","author":"Yamamoto","year":"2002","journal-title":"Hypertens. Res."},{"key":"2021113010564217500_B193","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1536\/ihj.51.252","article-title":"Fixed-dose telmisartan\/hydrochlorothiazide in comparison with losartan\/hydrochlorothiazide in decreasing serum hepatocyte growth factor and improving endothelial dysfunction in hypertensive patients","volume":"51","author":"Hu","year":"2010","journal-title":"Int. Heart J."},{"key":"2021113010564217500_B194","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0895-7061(02)02274-4","article-title":"Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients","volume":"15","author":"Komai","year":"2002","journal-title":"Am. J. Hypertens."},{"key":"2021113010564217500_B195","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1161\/01.HYP.0000046919.41112.4B","article-title":"Hepatocyte growth factor and left ventricular geometry in end-stage renal disease","volume":"41","author":"Malatino","year":"2003","journal-title":"Hypertension"},{"key":"2021113010564217500_B196","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1097\/00004872-199917090-00014","article-title":"Involvement of receptor-type tyrosine kinase gene families in cardiac hypertrophy","volume":"17","author":"Akiyama","year":"1999","journal-title":"J. Hypertens."},{"key":"2021113010564217500_B197","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1161\/HYPERTENSIONAHA.112.198986","article-title":"Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in\u00a0vivo","volume":"61","author":"Messaoudi","year":"2013","journal-title":"Hypertension"},{"key":"2021113010564217500_B198","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1136\/hrt.2010.220228","article-title":"Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure","volume":"97","author":"Rychli","year":"2011","journal-title":"Heart"},{"key":"2021113010564217500_B199","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/heart.83.4.450","article-title":"Production of hepatocyte growth factor during acute myocardial infarction","volume":"83","author":"Zhu","year":"2000","journal-title":"Heart"},{"key":"2021113010564217500_B200","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0006-291X(92)92375-8","article-title":"Up-regulation of hepatocyte growth factor gene expression by interleukin-1\u00a0in human skin fibroblasts","volume":"188","author":"Matsumoto","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113010564217500_B201","doi-asserted-by":"publisher","first-page":"588","DOI":"10.2183\/pjab.86.588","article-title":"The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine","volume":"86","author":"Nakamura","year":"2010","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"2021113010564217500_B202","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.molonc.2014.09.002","article-title":"TNF-\u03b1 promotes invasive growth through the MET signaling pathway","volume":"9","author":"Bigatto","year":"2015","journal-title":"Mol. Oncol."},{"key":"2021113010564217500_B203","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cyto.2014.07.255","article-title":"Evaluation of hepatocyte growth factor as a local acute phase response marker in the bowel: the clinical impact of a rapid diagnostic test for immediate identification of acute bowel inflammation","volume":"71","author":"Sorour","year":"2015","journal-title":"Cytokine"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/129\/12\/1173\/448416\/cs1291173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/129\/12\/1173\/448416\/cs1291173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:43:20Z","timestamp":1718192600000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/129\/12\/1173\/71806\/Cellular-and-molecular-mechanisms-of-HGF-Met-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,11]]},"references-count":203,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20150502","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,11]]}}}