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New therapeutic options need to be identified for the treatment of hypertension in order to increase the percentage of individuals with controlled BP. There is a growing basic science literature regarding the role of T-cells in the pathogenesis of hypertension and BP control; however, the majority of this literature has been performed exclusively in males despite the fact that both men and women develop hypertension. This is especially problematic since hypertension is well recognized as having distinct sex differences in the prevalence, absolute BP values and molecular mechanisms contributing to the pathophysiology of the disease. The purpose of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation.<\/jats:p>","DOI":"10.1042\/cs20150620","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T01:20:08Z","timestamp":1459560008000},"page":"773-783","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["T-cell involvement in sex differences in blood pressure control"],"prefix":"10.1042","volume":"130","author":[{"given":"G.\u00a0Ryan","family":"Crislip","sequence":"first","affiliation":[{"name":"Department of Physiology, Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA 30912, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer\u00a0C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA 30912, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"2021113010393867700_B1","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart disease and stroke statistics-2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"2021113010393867700_B2","first-page":"51","article-title":"Hypertension epidemiology and economic burden: refining risk assessment to lower costs","volume":"18","author":"Cohen","year":"2009","journal-title":"Manag. 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