{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:22:19Z","timestamp":1788895339685,"version":"build-2803163510"},"reference-count":74,"publisher":"Portland Press Ltd.","issue":"9","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":1224,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:p>Arthritis is a process of chronic inflammation that results in joint damage. IL (interleukin)-1\u03b2 is an inflammatory cytokine that acts as a key mediator of cartilage degradation, and is abundantly expressed in arthritis. Neovascularization is one of the pathological characteristics of arthritis. However, the role of IL-1\u03b2 in the angiogenesis of chondrocytes remains unknown. In the present study, we demonstrate that stimulating chondrocytes (ATDC5) with IL-1\u03b2 increased the expression of FGF (fibroblast growth factor)-2, a potent angiogenic inducer, and then promoted EPC (endothelial progenitor cell) tube formation and migration. In addition, FGF-2-neutralizing antibody abolished ATDC5-conditional medium-mediated angiogenesis in\u00a0vitro, as well as its angiogenic effects in the CAM (chick chorioallantoic membrane) assay and Matrigel plug nude mice model in\u00a0vivo. IHC (immunohistochemistry) staining from a CIA (collagen-induced arthritis) mouse model also demonstrates that arthritis increased the expression of IL-1\u03b2 and FGF-2, as well as EPC homing in articular cartilage. Moreover, IL-1\u03b2-induced FGF-2 expression via IL-1RI (type-1 IL-1 receptor), ROS (reactive oxygen species) generation, AMPK (AMP-activated protein kinase), p38 and NF-\u03baB (nuclear factor \u03baB) pathway has been demonstrated. On the basis of these findings, we conclude that IL-1\u03b2 promotes FGF-2 expression in chondrocytes through the ROS\/AMPK\/p38\/NF-\u03baB signalling pathway and subsequently increases EPC angiogenesis. Therefore IL-1\u03b2 serves as a link between inflammation and angiogenesis during arthritis.<\/jats:p>","DOI":"10.1042\/cs20150622","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T03:48:56Z","timestamp":1453780136000},"page":"667-681","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Interleukin-1\u03b2 induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes"],"prefix":"10.1042","volume":"130","author":[{"given":"Szu-Yu","family":"Chien","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun-Lin County, Taiwan"},{"name":"School of Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hao","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"},{"name":"Department of Orthopedic Surgery, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Medicine, China Medical University, Taichung, Taiwan"},{"name":"Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan"},{"name":"Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,3,18]]},"reference":[{"key":"2021113010482485000_B1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","article-title":"Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis","volume":"8","author":"Mapp","year":"2012","journal-title":"Nat. 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