{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:51:58Z","timestamp":1788951118753,"version":"build-2803163510"},"reference-count":65,"publisher":"Portland Press Ltd.","issue":"8","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:p>Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by CYP epoxygenases, and EETs are kidney protective in multiple pathologies. We determined the ability of an EET analogue, EET-A, to mitigate experimental radiation nephropathy. The kidney expression of the EET producing enzyme CYP2C11 was lower in rats that received total body irradiation (TBI rat) compared with non-irradiated control. At 12\u00a0weeks after TBI, the rats had higher systolic blood pressure and impaired renal afferent arteriolar function compared with control, and EET-A or captopril mitigated these abnormalities. The TBI rats had 3-fold higher blood urea nitrogen (BUN) compared with control, and EET-A or captopril decreased BUN by 40\u201360%. The urine albumin\/creatinine ratio was increased 94-fold in TBI rats, and EET-A or captopril attenuated that increase by 60\u201390%. In TBI rats, nephrinuria was elevated 30-fold and EET-A or captopril decreased it by 50\u201390%. Renal interstitial fibrosis, tubular and glomerular injury were present in the TBI rats, and each was decreased by EET-A or captopril. We further demonstrated elevated renal parenchymal apoptosis in TBI rats, which was mitigated by EET-A or captopril. Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53\/Fas\/FasL (Fas ligand) apoptotic pathway. The present study demonstrates a novel EET analogue-based strategy for mitigation of experimental radiation nephropathy by improving renal afferent arteriolar function and by decreasing renal apoptosis.<\/jats:p>","DOI":"10.1042\/cs20150778","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T02:23:05Z","timestamp":1452910985000},"page":"587-599","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy"],"prefix":"10.1042","volume":"130","author":[{"given":"Md. Abdul\u00a0Hye","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fish","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geneva","family":"Wahl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0R.","family":"Falck","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh\u00a0P.","family":"Paudyal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0E.","family":"Moulder","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0D.","family":"Imig","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric\u00a0P.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A."},{"name":"Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"2021113010472216900_B1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1053\/j.ajkd.2015.04.042","article-title":"Onco-nephrology: core curriculum","volume":"66","author":"Cohen","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"2021113010472216900_B2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ijrobp.2011.05.081","article-title":"Mitigation of late renal and pulmonary injury after hematopoietic stem cell transplantation","volume":"83","author":"Cohen","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"2021113010472216900_B3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1158\/1078-0432.CCR-10-1402","article-title":"Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators","volume":"17","author":"Movsas","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"2021113010472216900_B4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1067\/mlc.2002.122279","article-title":"The renin-angiotensin system in experimental radiation nephropathy","volume":"39","author":"Cohen","year":"2002","journal-title":"J. Lab. Clin. Med."},{"key":"2021113010472216900_B5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-3-540-49070-8","article-title":"Prevention and treatment of radiation injuries\u2013the role of the renin-angiotensin system","volume-title":"Late Effects of Cancer Treatment on Normal Tissues","author":"Cohen","year":"2008"},{"key":"2021113010472216900_B6","doi-asserted-by":"publisher","first-page":"F740","DOI":"10.1152\/ajprenal.00098.2009","article-title":"Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension","volume":"297","author":"Manhiani","year":"2009","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"2021113010472216900_B7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1042\/CS20080039","article-title":"Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats","volume":"116","author":"Olearczyk","year":"2009","journal-title":"Clin. Sci. (Lond)"},{"key":"2021113010472216900_B8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10565-008-9071-0","article-title":"Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase","volume":"25","author":"Parrish","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"2021113010472216900_B9","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1124\/mol.113.088302","article-title":"Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway","volume":"84","author":"Liu","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"2021113010472216900_B10","doi-asserted-by":"publisher","first-page":"F131","DOI":"10.1152\/ajprenal.00531.2014","article-title":"Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy","volume":"308","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021113010472216900_B11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/FJC.0b013e3181e96e0c","article-title":"Targeting epoxides for organ damage in hypertension","volume":"56","author":"Imig","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2021113010472216900_B12","doi-asserted-by":"crossref","first-page":"R579","DOI":"10.1152\/ajpregu.1994.267.2.R579","article-title":"Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats","volume":"267","author":"Ma","year":"1994","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010472216900_B13","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1161\/01.HYP.0000029240.44253.5E","article-title":"P450-dependent arachidonic acid metabolism and angiotensin II-induced renal damage","volume":"40","author":"Kaergel","year":"2002","journal-title":"Hypertension"},{"key":"2021113010472216900_B14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fphys.2010.00157","article-title":"Development of epoxyeicosatrienoic acid analogs with in\u00a0vivo anti-hypertensive actions","volume":"1","author":"Imig","year":"2010","journal-title":"Front. Physiol."},{"key":"2021113010472216900_B15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3389\/fphar.2014.00216","article-title":"Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury","volume":"5","author":"Khan","year":"2014","journal-title":"Front. Pharmacol."},{"key":"2021113010472216900_B16","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1096\/fj.12-218040","article-title":"Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity","volume":"27","author":"Khan","year":"2013","journal-title":"FASEB J."},{"key":"2021113010472216900_B17","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1161\/HYPERTENSIONAHA.113.01949","article-title":"Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat","volume":"62","author":"Hye Khan","year":"2013","journal-title":"Hypertension"},{"key":"2021113010472216900_B18","doi-asserted-by":"publisher","first-page":"13528","DOI":"10.1073\/pnas.1311565110","article-title":"Epoxyeicosanoids promote organ and tissue regeneration","volume":"110","author":"Panigrahy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010472216900_B19","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1046\/j.1523-1755.2000.00241.x","article-title":"Radiation nephropathy after bone marrow transplantation","volume":"58","author":"Cohen","year":"2000","journal-title":"Kidney Int."},{"key":"2021113010472216900_B20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/0002-9343(63)90120-7","article-title":"Early effects of radiation on renal function in man","volume":"34","author":"Avioli","year":"1963","journal-title":"Am. J. Med."},{"key":"2021113010472216900_B21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/08860229409045077","article-title":"Acute, subacute, and chronic X-ray effects on glomerular hemodynamics in rats","volume":"16","author":"Teixeira","year":"1994","journal-title":"Ren. Fail"},{"key":"2021113010472216900_B22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/0360-3016(92)90955-H","article-title":"Evidence for a renovascular component in hypertensive patients with late radiation nephropathy","volume":"30","author":"Verheij","year":"1994","journal-title":"Int. J. Radiat Oncol. Biol. Phys."},{"key":"2021113010472216900_B23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1259\/0007-1285-59-702-587","article-title":"Late radiation response of kidney assayed by tubule-cell survival","volume":"59","author":"Withers","year":"1986","journal-title":"Br. J. Radiol."},{"key":"2021113010472216900_B24","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1080\/09553008814552011","article-title":"Cell death by apoptosis following X-irradiation of the foetal and neonatal rat kidney","volume":"54","author":"Gob\u00e9","year":"1988","journal-title":"Int. J. Radiat. Biol."},{"key":"2021113010472216900_B25","doi-asserted-by":"publisher","first-page":"762","DOI":"10.3109\/09553002.2014.938375","article-title":"Mitigation of experimental radiation nephropathy by renin-equivalent doses of angiotensin converting enzyme inhibitors","volume":"90","author":"Moulder","year":"2014","journal-title":"Int. J. Radiat. Biol."},{"key":"2021113010472216900_B26","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/sj.bjp.0702662","article-title":"Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness","volume":"127","author":"Imig","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"2021113010472216900_B27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/10739680701456960","article-title":"Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ channels","volume":"15","author":"Imig","year":"2008","journal-title":"Microcirculation"},{"key":"2021113010472216900_B28","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1128\/MCB.15.6.3032","article-title":"Wild-type human p53 and a temperature-sensitive mutant induce Fas\/APO-1 expression","volume":"15","author":"Owen-Schaub","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"2021113010472216900_B29","doi-asserted-by":"publisher","first-page":"5774","DOI":"10.1038\/sj.onc.1206677","article-title":"p53 and radiation responses","volume":"22","author":"Fei","year":"2003","journal-title":"Oncogene"},{"key":"2021113010472216900_B30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000188587","article-title":"Bone marrow transplant nephropathy: radiation nephritis revisited","volume":"70","author":"Cohen","year":"1995","journal-title":"Nephron"},{"key":"2021113010472216900_B31","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0140-6736(15)00697-2","article-title":"Late-onset effects of radiation and chronic kidney disease","volume":"386","author":"Cohen","year":"2015","journal-title":"Lancet"},{"key":"2021113010472216900_B32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1067\/mlc.2002.122279","article-title":"The renin-angiotensin system in experimental radiation nephropathy","volume":"139","author":"Cohen","year":"2002","journal-title":"J. Lab. Clin. Med."},{"key":"2021113010472216900_B33","doi-asserted-by":"crossref","first-page":"AMP15","DOI":"10.1161\/hyp.66.suppl_1.mp15","article-title":"Afferent arteriolar endothelial-dependent dilation is impaired prior to the development of radiation-induced nephropathy and hypertension","volume":"66","author":"Imig","year":"2015","journal-title":"Hypertension"},{"key":"2021113010472216900_B34","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2307\/3577921","article-title":"A morphological study of radiation nephropathy in the pig","volume":"126","author":"Robbins","year":"1991","journal-title":"Radiat. Res."},{"key":"2021113010472216900_B35","first-page":"396","article-title":"Capillary endothelium. Target site of renal radiation injury","volume":"68","author":"Jaenke","year":"1993","journal-title":"Lab. Invest."},{"key":"2021113010472216900_B36","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1161\/01.HYP.30.3.672","article-title":"Abnormal endothelium-dependent responses in early radiation nephropathy","volume":"30","author":"Juncos","year":"1997","journal-title":"Hypertension"},{"key":"2021113010472216900_B37","first-page":"349","article-title":"Captopril preserves function and ultrastructure in experimental radiation nephropathy","volume":"75","author":"Cohen","year":"1996","journal-title":"Lab. Invest."},{"key":"2021113010472216900_B38","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1038\/ki.1989.132","article-title":"Delayed renal failure with extensive mesangiolysis following bone marrow transplantation","volume":"35","author":"Antignac","year":"1989","journal-title":"Kidney Int"},{"key":"2021113010472216900_B39","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1124\/jpet.109.159178","article-title":"Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk","volume":"332","author":"Donnini","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021113010472216900_B40","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1161\/HYPERTENSIONAHA.114.04187","article-title":"Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study","volume":"64","author":"Lankhorst","year":"2014","journal-title":"Hypertension"},{"key":"2021113010472216900_B41","first-page":"578","article-title":"Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries","volume":"7","author":"Campbell","year":"2001","journal-title":"Med. Sci. Monit."},{"key":"2021113010472216900_B42","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1161\/01.HYP.0000153462.06604.5d","article-title":"14,15-Epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries","volume":"45","author":"Gauthier","year":"2005","journal-title":"Hypertension"},{"key":"2021113010472216900_B43","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejphar.2010.12.016","article-title":"Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension","volume":"654","author":"Zhang","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"2021113010472216900_B44","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1159\/000051053","article-title":"Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin","volume":"38","author":"Imig","year":"2001","journal-title":"J. Vasc. Res."},{"key":"2021113010472216900_B45","doi-asserted-by":"publisher","first-page":"R1307","DOI":"10.1152\/ajpregu.00759.2010","article-title":"Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type\u00a01 diabetes","volume":"301","author":"Elmarakby","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021113010472216900_B46","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1161\/01.HYP.0000118053.42262.71","article-title":"Role of endothelium-derived hyperpolarizing factor in ACE inhibitor-induced renal vasodilation in\u00a0vivo","volume":"43","author":"Matsuda","year":"2004","journal-title":"Hypertension"},{"key":"2021113010472216900_B47","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1042\/CS20130479","article-title":"Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition","volume":"127","author":"Hye Khan","year":"2014","journal-title":"Clin. Sci. (Lond)"},{"key":"2021113010472216900_B48","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.mehy.2012.11.022","article-title":"Chronic oxidative stress after irradiation: an unproven hypothesis","volume":"80","author":"Cohen","year":"2013","journal-title":"Med. Hypotheses"},{"key":"2021113010472216900_B49","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1667\/RR1454.1","article-title":"Chronic oxidative stress as a mechanism for radiation nephropathy","volume":"171","author":"Lenarczyk","year":"2009","journal-title":"Radiat Res."},{"key":"2021113010472216900_B50","article-title":"Evaluation of genomic evidence for oxidative stress in experimental radiation nephropathy","volume":"2","author":"Cohen","year":"2013","journal-title":"J. Genet. Disord. Genet. Rep."},{"key":"2021113010472216900_B51","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1080\/02841860152708233","article-title":"Radiation nephropathy the link between functional damage and vascular mediated inflammatory and thrombotic changes","volume":"40","author":"Stewart","year":"2001","journal-title":"Acta Oncol."},{"key":"2021113010472216900_B52","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1080\/095530000138303","article-title":"Long-term effects of total-body irradiation on the kidney of Rhesus monkeys","volume":"76","author":"van Kleef","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"key":"2021113010472216900_B53","doi-asserted-by":"publisher","first-page":"G599","DOI":"10.1152\/ajpgi.00564.2004","article-title":"Polyamine depletion inhibits irradiation-induced apoptosis in intestinal epithelia","volume":"289","author":"Deng","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2021113010472216900_B54","first-page":"321","article-title":"Radiation-induced apoptosis of endothelial cells in the murine central nervous system: protection by fibroblast growth factor and sphingomyelinase deficiency","volume":"60","author":"Pena","year":"2000","journal-title":"Cancer Res."},{"key":"2021113010472216900_B55","first-page":"1197","article-title":"Early ultrastructural lesions of apoptosis induced in\u00a0vivo in two varieties of tissues (thymus and kidney) after a single whole body gamma irradiation of adult mice","volume":"43","author":"Ghassah","year":"1997","journal-title":"Cell Mol. Biol."},{"key":"2021113010472216900_B56","first-page":"86","article-title":"Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats","volume":"74","author":"Kajstura","year":"1996","journal-title":"Lab. Invest."},{"key":"2021113010472216900_B57","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/ki.2010.317","article-title":"Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure","volume":"79","author":"Linkermann","year":"2011","journal-title":"Kidney Int."},{"key":"2021113010472216900_B58","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.V94620","article-title":"Induction of apoptosis in ischemia-reperfusion model of mouse kidney: possible involvement of Fas","volume":"9","author":"Nogae","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113010472216900_B59","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/jnci\/djj335","article-title":"Irradiation-induced pneumonitis mediated by the CD95\/CD95-ligand system","volume":"98","author":"Heinzelmann","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"2021113010472216900_B60","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00066-013-0485-0","article-title":"Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy","volume":"190","author":"Thurner","year":"2014","journal-title":"Strahlenther Onkol"},{"key":"2021113010472216900_B61","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4161\/cc.1.3.118","article-title":"Linking DNA damage to cell cycle checkpoints","volume":"1","author":"Samuel","year":"2002","journal-title":"Cell Cycle"},{"key":"2021113010472216900_B62","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1084\/jem.188.11.2033","article-title":"p53 activates the CD95 (APO-1\/Fas) gene in response to DNA damage by anticancer drugs","volume":"188","author":"M\u00fcller","year":"1998","journal-title":"J. Exp. Med."},{"key":"2021113010472216900_B63","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.biocel.2014.02.020","article-title":"Inhibitory effect of 14,15-EET on endothelial senescence through activation of mTOR complex 2\/Akt signaling pathways","volume":"50","author":"Yang","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021113010472216900_B64","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000316703","article-title":"Role of Fosinopril and Valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells","volume":"33","author":"Zhou","year":"2010","journal-title":"Kidney Blood Press. Res."},{"key":"2021113010472216900_B65","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/nature14569","article-title":"Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment","volume":"523","author":"Li","year":"2015","journal-title":"Nature"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/130\/8\/587\/447310\/cs1300587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/130\/8\/587\/447310\/cs1300587.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T19:54:03Z","timestamp":1654113243000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/130\/8\/587\/71523\/Epoxyeicosatrienoic-acid-analogue-mitigates-kidney"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20150778","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]}}}