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This brief review is to summarize the neural mechanisms of hypertension with a focus on neuroendocrine and neurotransmitter involvement, highlighting recent findings that suggest that hypothalamic inflammation disrupts key signalling pathways to affect the central control of blood pressure, and therefore suggesting future development of interventional strategies that exploit recent findings pertaining to the hypothalamic control of blood pressure as well as the inflammatory\u2013sympathetic mechanisms involved in hypertension.<\/jats:p>","DOI":"10.1042\/cs20160001","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:50:19Z","timestamp":1483649419000},"page":"211-223","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hypothalamic and inflammatory basis of hypertension"],"prefix":"10.1042","volume":"131","author":[{"given":"Sinan","family":"Khor","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."},{"name":"Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."},{"name":"Institute of Aging, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."},{"name":"Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."},{"name":"Institute of Aging, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"2021113010501097100_B1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.cjca.2015.01.009","article-title":"Global burden of cardiovascular disease and stroke: hypertension at the core","volume":"31","author":"Lackland","year":"2015","journal-title":"Can. 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