{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:38:49Z","timestamp":1791999529404,"version":"4.4.0"},"reference-count":158,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":958,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>Endothelial cells that form the inner layer of blood and lymphatic vessels are important regulators of vascular functions and centrally involved in the pathogenesis of vascular diseases. In addition to the vascular endothelial growth factor (VEGF) receptor pathway, the angiopoietin (Ang)\u2013Tie system is a second endothelial cell specific ligand\u2013receptor signalling system necessary for embryonic cardiovascular and lymphatic development. The Ang\u2013Tie system also regulates postnatal angiogenesis, vessel remodelling, vascular permeability and inflammation to maintain vascular homoeostasis in adult physiology. This system is implicated in numerous diseases where the vasculature has an important contribution, such as cancer, sepsis, diabetes, atherosclerosis and ocular diseases. Furthermore, mutations in the TIE2 signalling pathway cause defects in vascular morphogenesis, resulting in venous malformations and primary congenital glaucoma. Here, we review recent advances in the understanding of the Ang\u2013Tie signalling system, including cross-talk with the vascular endothelial protein tyrosine phosphatase (VE-PTP) and the integrin cell adhesion receptors, focusing on the Ang\u2013Tie system in vascular development and pathogenesis of vascular diseases.<\/jats:p>","DOI":"10.1042\/cs20160129","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T22:20:48Z","timestamp":1481322048000},"page":"87-103","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":185,"title":["Angiopoietin\u2013Tie signalling in the cardiovascular and lymphatic systems"],"prefix":"10.1042","volume":"131","author":[{"given":"Lauri","family":"Eklund","sequence":"first","affiliation":[{"name":"Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, Aapistie 5A, FI-90014 Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Kangas","sequence":"additional","affiliation":[{"name":"Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu, Aapistie 5A, FI-90014 Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pipsa","family":"Saharinen","sequence":"additional","affiliation":[{"name":"Translational Cancer Biology Program, Research Programs Unit, University of Helsinki, and Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, P.O.B. 63, FI-00014 University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"2021113010502236200_B1","doi-asserted-by":"publisher","first-page":"a009183","DOI":"10.1101\/cshperspect.a009183","article-title":"Receptor tyrosine kinase-mediated angiogenesis","volume":"5","author":"Jeltsch","year":"2013","journal-title":"Cold. 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