{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:42:55Z","timestamp":1769596975170,"version":"3.49.0"},"reference-count":145,"publisher":"Portland Press Ltd.","issue":"16","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:p>The term \u2018epigenetics\u2019 refers to heritable, reversible DNA or histone modifications that affect gene expression without modifying the DNA sequence. Epigenetic modulation of gene expression also includes the RNA interference mechanism. Epigenetic regulation of gene expression is fundamental during development and throughout life, also playing a central role in disease progression. The transforming growth factor \u03b21 (TGF-\u03b21) and its downstream effectors are key players in tissue repair and fibrosis, extracellular matrix remodelling, inflammation, cell proliferation and migration. TGF-\u03b21 can also induce cell switch in epithelial-to-mesenchymal transition, leading to myofibroblast transdifferentiation. Cellular pathways triggered by TGF-\u03b21 in thoracic ascending aorta dilatation have relevant roles to play in remodelling of the vascular wall by virtue of their association with monogenic syndromes that implicate an aortic aneurysm, including Loeys\u2013Dietz and Marfan's syndromes. Several studies and reviews have focused on the progression of aneurysms in the abdominal aorta, but research efforts are now increasingly being focused on pathogenic mechanisms of thoracic ascending aorta dilatation. The present review summarizes the most recent findings concerning the epigenetic regulation of effectors of TGF-\u03b21 pathways, triggered by sporadic dilative aortopathy of the thoracic ascending aorta in the presence of a tricuspid or bicuspid aortic valve, a congenital malformation occurring in 0.5\u20132% of the general population. A more in-depth comprehension of the epigenetic alterations associated with TGF-\u03b21 canonical and non-canonical pathways in dilatation of the ascending aorta could be helpful to clarify its pathogenesis, identify early potential biomarkers of disease, and, possibly, develop preventive and therapeutic strategies.<\/jats:p>","DOI":"10.1042\/cs20160222","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T01:23:53Z","timestamp":1467941033000},"page":"1389-1405","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Epigenetic regulation of TGF-\u03b21 signalling in dilative aortopathy of the thoracic ascending aorta"],"prefix":"10.1042","volume":"130","author":[{"given":"Amalia","family":"Forte","sequence":"first","affiliation":[{"name":"Experimental Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Galderisi","sequence":"additional","affiliation":[{"name":"Experimental Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Cipollaro","sequence":"additional","affiliation":[{"name":"Experimental Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"De Feo","sequence":"additional","affiliation":[{"name":"Cardiothoracic Sciences, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro\u00a0Della","family":"Corte","sequence":"additional","affiliation":[{"name":"Cardiothoracic Sciences, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"2021113010413996500_B1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00005082-200507000-00008","article-title":"Thoracic aortic aneurysms","volume":"20","author":"Klein","year":"2005","journal-title":"J. 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