{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:34:54Z","timestamp":1792708494925,"version":"4.5.0"},"reference-count":43,"publisher":"Portland Press Ltd.","issue":"22","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:p>Gut microbial-derived short-chain fatty acids (SCFA) are believed to affect host metabolism and cardiometabolic risk factors. The present study aim was to investigate the effects of proximal and distal colonic infusions with the SCFA acetate on fat oxidation and other metabolic parameters in men. In this randomized, double-blind crossover trial, six overweight\/obese men [body mass index (BMI) 25\u201335\u00a0kg\/m2] underwent two experimental periods: one with distal and one with proximal colonic sodium acetate infusions. A feeding catheter was endoscopically positioned at the beginning of each period and remained in the colon for three consecutive test days, enabling colonic acetate (100\u00a0or\u00a0180\u00a0mmol\/l) or placebo infusion during fasting conditions and after an oral glucose load (postprandial). Fat oxidation and energy expenditure were measured using an open-circuit ventilated hood system and blood samples were repeatedly collected for 2\u00a0h during fasting and postprandial conditions. Distal colonic 180\u00a0mmol\/l acetate infusions increased fasting fat oxidation (1.78\u00b10.28 compared with \u22120.78\u00b10.89\u00a0g fat 2 h\u22121, P=0.015), fasting peptide YY (PYY, P=0.01) and postprandial glucose and insulin concentrations (P&amp;lt;0.05), and tended to increase fasting plasma acetate (P=0.069) compared with placebo. Distal 100\u00a0mmol\/l acetate administration tended to decrease fasting tumour necrosis factor-\u03b1 (TNF-\u03b1; P=0.067) compared with placebo. In contrast, proximal colonic acetate infusions showed no effects on substrate metabolism, circulating hormones or inflammatory markers. In conclusion distal colonic acetate infusions affected whole-body substrate metabolism, with a pronounced increase in fasting fat oxidation and plasma PYY. Modulating colonic acetate may be a nutritional target to treat or prevent metabolic disorders.<\/jats:p>","DOI":"10.1042\/cs20160263","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T02:29:02Z","timestamp":1469068142000},"page":"2073-2082","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":223,"title":["Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight\/obese men"],"prefix":"10.1042","volume":"130","author":[{"given":"Christina\u00a0M.","family":"van der Beek","sequence":"first","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel\u00a0E.","family":"Canfora","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6229 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaatje","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy\u00a0J.","family":"Troost","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Internal Medicine, Division of Gastroenterology-Hepatology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6229 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.M.","family":"Olde Damink","sequence":"additional","affiliation":[{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands"},{"name":"Department of HPB Surgery and Liver Transplantation, Institute of Liver and Digestive Health, University College London, London WC1 6HX, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens\u00a0J.","family":"Holst","sequence":"additional","affiliation":[{"name":"NNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen 2200, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00a0A.M.","family":"Masclee","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Internal Medicine, Division of Gastroenterology-Hepatology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6229 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis\u00a0H.C.","family":"Dejong","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6299 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen\u00a0E.","family":"Blaak","sequence":"additional","affiliation":[{"name":"Top Institute Food and Nutrition, Wageningen, 6700 AN, The Netherlands"},{"name":"Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, 6229 ER, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"2021113010434854800_B1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1467-789X.2010.00797.x","article-title":"Do nutrient\u2013gut\u2013microbiota interactions play a role in human obesity, insulin resistance and type\u00a02 diabetes?","volume":"12","author":"Diamant","year":"2011","journal-title":"Obes. 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