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Recent data suggest that sterol-binding sensors, exchangers and transporters contribute to regulation of cellular cholesterol homoeostasis and that genetic overexpression or deletion, or mutations, in a number of these proteins are linked with diseases, including atherosclerosis, dyslipidaemia, diabetes, congenital lipoid adrenal hyperplasia, cancer, autosomal dominant hearing loss and male infertility. This review focuses on current evidence exploring the function of members of the \u2018START\u2019 (steroidogenic acute regulatory protein-related lipid transfer) and \u2018ORP\u2019 (oxysterol-binding protein-related proteins) families of sterol-binding proteins in sterol homoeostasis in eukaryotic cells, and the evidence that they represent valid therapeutic targets to alleviate human disease.<\/jats:p>","DOI":"10.1042\/cs20160339","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T01:28:55Z","timestamp":1474594135000},"page":"1843-1859","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Intracellular cholesterol transport proteins: roles in health and disease"],"prefix":"10.1042","volume":"130","author":[{"given":"Ugo","family":"Soffientini","sequence":"first","affiliation":[{"name":"Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"2021113010481819700_B1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.2741\/4216","article-title":"Physiological and pathological implications of cholesterol","volume":"19","author":"Cortes","year":"2014","journal-title":"Front. 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