{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:19:36Z","timestamp":1762867176696},"reference-count":225,"publisher":"Portland Press Ltd.","issue":"14","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:p>Chronic kidney disease (CKD), affecting 10\u201312% of the world\u2019s adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death. Although a wide spectrum of causative factors has been identified and\/or suggested, there is still a large gap of knowledge regarding the underlying mechanisms and the complexity of the CKD phenotype. Epigenetic factors, which calibrate the genetic code, are emerging as important players in the CKD-associated pathophysiology. In this article, we review some of the current knowledge on epigenetic modifications and aspects on their role in the perturbed uraemic milieu, as well as the prospect of applying epigenotype-based diagnostics and preventive and therapeutic tools of clinical relevance to CKD patients. The practical realization of such a paradigm will require that researchers apply a holistic approach, including the full spectrum of the epigenetic landscape as well as the variability between and within tissues in the uraemic milieu.<\/jats:p>","DOI":"10.1042\/cs20160596","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:10:36Z","timestamp":1498867836000},"page":"1649-1667","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Current epigenetic aspects the clinical kidney researcher should embrace"],"prefix":"10.1042","volume":"131","author":[{"given":"Anna","family":"Witasp","sequence":"first","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaryllis\u00a0H.","family":"Van Craenenbroeck","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Nephrology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul\u00a0G.","family":"Shiels","sequence":"additional","affiliation":[{"name":"Institute of Cancer Sciences, MVLS, University of Glasgow, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas\u00a0J.","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Nordfors","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden"},{"name":"Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"2021113010573342200_B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30788-2","article-title":"Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy","author":"Levin","year":"2017","journal-title":"Lancet"},{"key":"2021113010573342200_B2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/01.EDE.0000071413.55296.c4","article-title":"Lifestyle factors, obesity and the risk of chronic kidney disease","volume":"14","author":"Stengel","year":"2003","journal-title":"Epidemiology"},{"key":"2021113010573342200_B3","doi-asserted-by":"crossref","first-page":"587983","DOI":"10.1155\/2015\/587983","article-title":"Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention","volume":"2015","author":"Romani","year":"2015","journal-title":"BioMed Res. 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