{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:14:31Z","timestamp":1789661671339,"version":"4.0.1"},"reference-count":54,"publisher":"Portland Press Ltd.","issue":"7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:p>Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery, acts as an agonist of transient receptor potential vanilloid 4 (TRPV4). However, whether apigenin reduces hypertension-induced renal fibrosis, as well as the underlying mechanism, remains elusive. In the present study, the deoxycorticosterone acetate (DOCA)\u2013salt hypertension model was established in male Sprague-Dawley rats that were treated with apigenin or vehicle for 4\u00a0weeks. Apigenin significantly attenuated the DOCA\u2013salt-induced structural and functional damage to the kidney, which was accompanied by reduced expression of transforming growth factor-\u03b21 (TGF-\u03b21)\/Smad2\/3 signaling pathway and extracellular matrix proteins. Immunochemistry, cell-attached patch clamp and fluorescent Ca2+ imaging results indicated that TRPV4 was expressed and activated by apigenin in both the kidney and renal cells. Importantly, knockout of TRPV4\u00a0in mice abolished the beneficial effects of apigenin that were observed in the DOCA\u2013salt hypertensive rats. Additionally, apigenin directly inhibited activation of the TGF-\u03b21\/Smad2\/3 signaling pathway in different renal tissues through activation of TRPV4 regardless of the type\u00a0of pro-fibrotic stimulus. Moreover, the TRPV4-mediated intracellular Ca2+ influx activated the AMP-activated protein kinase (AMPK)\/sirtuin 1 (SIRT1) pathway, which inhibited the TGF-\u03b21\/Smad2\/3 signaling pathway. In summary, dietary apigenin has beneficial effects on hypertension-induced renal fibrosis through the TRPV4-mediated activation of AMPK\/SIRT1 and inhibition of the TGF-\u03b21\/Smad2\/3 signaling pathway. This work suggests that dietary apigenin may represent a promising lifestyle modification for the prevention of hypertension-induced renal damage in populations that consume a high-sodium diet.<\/jats:p>","DOI":"10.1042\/cs20160780","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T01:10:15Z","timestamp":1485911415000},"page":"567-581","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)\u2013salt-induced hypertension"],"prefix":"10.1042","volume":"131","author":[{"given":"Xing","family":"Wei","sequence":"first","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Pu","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanting","family":"Cui","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Molecular Pharmacology, School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"2021113011071629100_B1","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1016\/S0140-6736(12)61272-0","article-title":"Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis","volume":"380","author":"Mahmoodi","year":"2012","journal-title":"Lancet"},{"key":"2021113011071629100_B2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s004670000461","article-title":"Molecular basis of renal fibrosis","volume":"15","author":"Eddy","year":"2000","journal-title":"Pediatr. Nephrol."},{"key":"2021113011071629100_B3","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.lfs.2006.05.017","article-title":"Role of dietary salt in hypertension","volume":"79","author":"Haddy","year":"2006","journal-title":"Life Sci"},{"key":"2021113011071629100_B4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0959-437X(98)80069-5","article-title":"SMADs: mediators and regulators of TGF-beta signaling","volume":"8","author":"Kretzschmar","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2021113011071629100_B5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0955-2235(92)90017-C","article-title":"In\u00a0vivo interactions of TGF-beta and extracellular matrix","volume":"4","author":"Noble","year":"1992","journal-title":"Prog. Growth Factor Res."},{"key":"2021113011071629100_B6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1001\/jamainternmed.2013.12700","article-title":"Renoprotective effect of renin-angiotensin-aldosterone system blockade in patients with predialysis advanced chronic kidney disease, hypertension, and anemia","volume":"174","author":"Hsu","year":"2014","journal-title":"JAMA Inter. Med."},{"key":"2021113011071629100_B7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ki.2011.313","article-title":"Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy","volume":"81","author":"Goraya","year":"2012","journal-title":"Kidney Int"},{"key":"2021113011071629100_B8","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/j.1476-5381.2010.01070.x","article-title":"Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFbeta1 expression and activation of p38-MAPK and ERK1\/2","volume":"162","author":"Pan","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"2021113011071629100_B9","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/ptr.2364","article-title":"Scutellarin-induced endothelium-independent relaxation in rat aorta","volume":"22","author":"Pan","year":"2008","journal-title":"Phytother. Res."},{"key":"2021113011071629100_B10","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1161\/01.RES.0000194321.60300.d6","article-title":"TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels","volume":"97","author":"Earley","year":"2005","journal-title":"Circ. Res."},{"key":"2021113011071629100_B11","doi-asserted-by":"publisher","first-page":"e827","DOI":"10.1371\/journal.pone.0000827","article-title":"Arterial response to shear stress critically depends on endothelial TRPV4 expression","volume":"2","author":"Hartmannsgruber","year":"2007","journal-title":"PLoS One"},{"key":"2021113011071629100_B12","doi-asserted-by":"publisher","first-page":"H466","DOI":"10.1152\/ajpheart.00854.2009","article-title":"TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress","volume":"298","author":"Mendoza","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011071629100_B13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.bbrc.2009.09.007","article-title":"Identification and characterization of novel TRPV4 modulators","volume":"389","author":"Vincent","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021113011071629100_B14","doi-asserted-by":"publisher","first-page":"H634","DOI":"10.1152\/ajpheart.00717.2011","article-title":"Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling","volume":"302","author":"Bubolz","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011071629100_B15","doi-asserted-by":"publisher","first-page":"H1096","DOI":"10.1152\/ajpheart.00241.2009","article-title":"TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure","volume":"297","author":"Earley","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021113011071629100_B16","doi-asserted-by":"publisher","first-page":"e00199","DOI":"10.1002\/phy2.199","article-title":"Characterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension","volume":"2","author":"Nishijima","year":"2014","journal-title":"Physiol. Rep."},{"key":"2021113011071629100_B17","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/apha.12051","article-title":"Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney","volume":"207","author":"Kassmann","year":"2013","journal-title":"Acta Physiol"},{"key":"2021113011071629100_B18","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1126\/science.1216283","article-title":"Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function","volume":"336","author":"Sonkusare","year":"2012","journal-title":"Science"},{"key":"2021113011071629100_B19","doi-asserted-by":"publisher","first-page":"304\u2013314 e2","DOI":"10.1053\/j.gastro.2010.04.010","article-title":"Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD","volume":"139","author":"Gradilone","year":"2010","journal-title":"Gastroenterology"},{"key":"2021113011071629100_B20","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1681\/ASN.2012050442","article-title":"TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease","volume":"24","author":"Zaika","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011071629100_B21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cmet.2005.05.009","article-title":"Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase","volume":"2","author":"Hawley","year":"2005","journal-title":"Cell Metab"},{"key":"2021113011071629100_B22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2005.06.005","article-title":"Ca2+\/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells","volume":"2","author":"Woods","year":"2005","journal-title":"Cell Metab"},{"key":"2021113011071629100_B23","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1016\/j.ajpath.2015.04.014","article-title":"Activation of AMP-activated protein kinase prevents TGF-beta1-induced epithelial-mesenchymal transition and myofibroblast activation","volume":"185","author":"Thakur","year":"2015","journal-title":"Am. J. Pathol."},{"key":"2021113011071629100_B24","doi-asserted-by":"publisher","first-page":"F1067","DOI":"10.1152\/ajprenal.00005.2010","article-title":"Role of the energy sensor AMP-activated protein kinase in renal physiology and disease","volume":"298","author":"Hallows","year":"2010","journal-title":"Am. J. Physiol-Renal."},{"key":"2021113011071629100_B25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1042\/CS20120190","article-title":"Sirtuins and renal diseases: relationship with aging and diabetic nephropathy","volume":"124","author":"Kitada","year":"2013","journal-title":"Clin. Sci."},{"key":"2021113011071629100_B26","doi-asserted-by":"publisher","first-page":"5225","DOI":"10.1172\/JCI75331","article-title":"TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice","volume":"124","author":"Rahaman","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2021113011071629100_B27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1161\/01.HYP.9.2.178","article-title":"Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats","volume":"9","author":"Owens","year":"1987","journal-title":"Hypertension"},{"key":"2021113011071629100_B28","doi-asserted-by":"publisher","first-page":"477","DOI":"10.4196\/kjpp.2016.20.5.477","article-title":"Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats","volume":"20","author":"Lee","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"2021113011071629100_B29","doi-asserted-by":"publisher","first-page":"22664","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021113011071629100_B30","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.2119\/molmed.2011.00063","article-title":"Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-beta\/Smad signaling in DOCA-salt hypertension","volume":"17","author":"Wang","year":"2011","journal-title":"Mol. Med."},{"key":"2021113011071629100_B31","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.cmet.2010.05.015","article-title":"Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension","volume":"12","author":"Yang","year":"2010","journal-title":"Cell Metab"},{"key":"2021113011071629100_B32","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/ki.1987.262","article-title":"The enhancement of aminonucleoside nephrosis by the co-administration of protamine","volume":"32","author":"Saito","year":"1987","journal-title":"Kidney Int"},{"key":"2021113011071629100_B33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-5-5","article-title":"Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C","volume":"5","author":"Cao","year":"2009","journal-title":"Mol. Pain."},{"key":"2021113011071629100_B34","doi-asserted-by":"publisher","first-page":"762","DOI":"10.2337\/db12-0570","article-title":"Telmisartan improves insulin resistance of skeletal muscle through peroxisome proliferator-activated receptor-delta activation","volume":"62","author":"Li","year":"2013","journal-title":"Diabetes"},{"key":"2021113011071629100_B35","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1046\/j.1523-1755.2003.00929.x","article-title":"Aldosterone\/salt induces renal inflammation and fibrosis in hypertensive rats","volume":"63","author":"Blasi","year":"2003","journal-title":"Kidney Int"},{"key":"2021113011071629100_B36","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1172\/JCI118867","article-title":"Role of aldosterone in the remnant kidney model in the rat","volume":"98","author":"Greene","year":"1996","journal-title":"J. Clin Invest."},{"key":"2021113011071629100_B37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00109-013-1111-4","article-title":"Overexpression of SIRT1\u00a0in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice","volume":"92","author":"Gao","year":"2014","journal-title":"J. Mol. Med."},{"key":"2021113011071629100_B38","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/jcb.24748","article-title":"Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-beta\/Smad3 pathway","volume":"115","author":"Huang","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"2021113011071629100_B39","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.celrep.2013.03.019","article-title":"SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis","volume":"3","author":"Simic","year":"2013","journal-title":"Cell Rep"},{"key":"2021113011071629100_B40","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1097\/01.ASN.0000127045.14709.75","article-title":"Development of chronic kidney disease and cardiovascular prognosis in essential hypertensive patients","volume":"15","author":"Segura","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011071629100_B41","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"2021113011071629100_B42","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1056\/NEJMoa1208799","article-title":"Cardiorenal end points in a trial of aliskiren for type\u00a02 diabetes","volume":"367","author":"Parving","year":"2012","journal-title":"New. Engl. J. Med."},{"key":"2021113011071629100_B43","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","article-title":"Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention","volume":"382","author":"Gansevoort","year":"2013","journal-title":"Lancet"},{"key":"2021113011071629100_B44","doi-asserted-by":"publisher","first-page":"d4366","DOI":"10.1136\/bmj.d4366","article-title":"Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial","volume":"343","author":"Slagman","year":"2011","journal-title":"BMJ"},{"key":"2021113011071629100_B45","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1681\/ASN.2007060693","article-title":"Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan","volume":"19","author":"Vogt","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011071629100_B46","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1046\/j.1523-1755.1999.00656.x","article-title":"Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in\u00a0vitro","volume":"56","author":"Fan","year":"1999","journal-title":"Kidney Int."},{"key":"2021113011071629100_B47","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1681\/ASN.2013101137","article-title":"Curtailing endothelial TGF-beta signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD","volume":"26","author":"Xavier","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011071629100_B48","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3389\/fphys.2015.00082","article-title":"TGF-beta\/Smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front. Physiol."},{"key":"2021113011071629100_B49","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1589\/jpts.27.303","article-title":"A review of deoxycorticosterone acetate-salt hypertension and its relevance for cardiovascular physiotherapy research","volume":"27","author":"Lee","year":"2015","journal-title":"J. Phys. Ther. Sci."},{"key":"2021113011071629100_B50","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nrneph.2010.30","article-title":"Aldosterone: effects on the kidney and cardiovascular system","volume":"6","author":"Briet","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"2021113011071629100_B51","doi-asserted-by":"publisher","first-page":"F1399","DOI":"10.1152\/ajprenal.00604.2012","article-title":"Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria","volume":"304","author":"Ardiles","year":"2013","journal-title":"Am. J. Physiol. Renal."},{"key":"2021113011071629100_B52","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1161\/HYPERTENSIONAHA.108.110197","article-title":"Deletion of transient receptor potential vanilloid type\u00a01 receptors exaggerates renal damage in deoxycorticosterone acetate-salt hypertension","volume":"52","author":"Wang","year":"2008","journal-title":"Hypertension"},{"key":"2021113011071629100_B53","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1161\/HYPERTENSIONAHA.114.03105","article-title":"Transient receptor potential vanilloid 1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel alpha subunit-mediated sodium reabsorption","volume":"64","author":"Li","year":"2014","journal-title":"Hypertension"},{"key":"2021113011071629100_B54","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1161\/HYPERTENSIONAHA.107.100339","article-title":"Downregulation of renal TRPM7 and increased inflammation and fibrosis in aldosterone-infused mice: effects of magnesium","volume":"51","author":"Sontia","year":"2008","journal-title":"Hypertension"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/131\/7\/567\/445442\/cs1310567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/131\/7\/567\/445442\/cs1310567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:04:16Z","timestamp":1638273856000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/131\/7\/567\/77818\/Activation-of-TRPV4-by-dietary-apigenin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20160780","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,17]]}}}