{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:38:55Z","timestamp":1790433535548,"version":"4.1.0"},"reference-count":146,"publisher":"Portland Press Ltd.","issue":"11","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:p>Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine\/chemokine release, production of reactive oxygen species (ROS), circulating and local formation of trophic factors and of renin\u2013angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney\u2013brain cross-talk. In addition, we hypothesize potential pathways for the interactions between kidney and brain and their pathophysiological role in neuropsychiatric and cognitive changes found in patients with CKD. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment and to develop new strategies for innovative pharmacological treatment.<\/jats:p>","DOI":"10.1042\/cs20160927","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:30:18Z","timestamp":1495067418000},"page":"1093-1105","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Kidney\u2013brain axis inflammatory cross-talk: from bench to bedside"],"prefix":"10.1042","volume":"131","author":[{"given":"Aline\u00a0Silva","family":"Miranda","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Brazil"},{"name":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica (LIIM), Faculdade de Medicina, UFMG, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago\u00a0Macedo","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica (LIIM), Faculdade de Medicina, UFMG, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Mucida","family":"dos Santos\u00a0Lacerda Soares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica (LIIM), Faculdade de Medicina, UFMG, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo\u00a0Novaes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurobiologia, Departamento de Morfologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00a0Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Investiga\u00e7\u00e3o M\u00e9dica (LIIM), Faculdade de Medicina, UFMG, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"2021113010512415500_B1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/POR.S97310","article-title":"Chronic kidney disease: identification and management in primary care","volume":"7","author":"Fraser","year":"2016","journal-title":"Pragmat. Obs. Res."},{"key":"2021113010512415500_B2","doi-asserted-by":"publisher","first-page":"e004251","DOI":"10.1136\/bmjopen-2013-004251","article-title":"Mortality in chronic kidney disease and renal replacement therapy: a population-based cohort study","volume":"4","author":"Neovius","year":"2014","journal-title":"BMJ Open"},{"key":"2021113010512415500_B3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12882-015-0189-z","article-title":"The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study","volume":"16","author":"Fraser","year":"2015","journal-title":"BMC Nephrol"},{"key":"2021113010512415500_B4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/ki.2015.228","article-title":"Comorbidity as a driver of adverse outcomes in people with chronic kidney disease","volume":"88","author":"Tonelli","year":"2015","journal-title":"Kidney Int."},{"key":"2021113010512415500_B5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1093\/pubmed\/fdt117","article-title":"Chronic kidney disease, albuminuria and socioeconomic status in the Health Surveys for England 2009 and 2010","volume":"36","author":"Fraser","year":"2014","journal-title":"J. Public Health (Oxf.)"},{"key":"2021113010512415500_B6","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"2021113010512415500_B7","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/ki.2011.368","article-title":"The contribution of chronic kidney disease to the global burden of major noncommunicable diseases","volume":"80","author":"Couser","year":"2011","journal-title":"Kidney Int"},{"key":"2021113010512415500_B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1053\/ajkd.2003.50007","article-title":"Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey","volume":"41","author":"Coresh","year":"2003","journal-title":"Am. J. Kidney Dis."},{"key":"2021113010512415500_B9","doi-asserted-by":"publisher","first-page":"e0118676","DOI":"10.1371\/journal.pone.0118676","article-title":"Exploration of chronic kidney disease prevalence estimates using new measures of kidney function in the health survey for England","volume":"10","author":"Fraser","year":"2015","journal-title":"PLoS One"},{"key":"2021113010512415500_B10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/qjmed\/hcn177","article-title":"The effect of ethnicity on the prevalence of diabetes and associated chronic kidney disease","volume":"102","author":"Dreyer","year":"2009","journal-title":"QJM"},{"key":"2021113010512415500_B11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/qjmed\/hcr153","article-title":"Social deprivation and prevalence of chronic kidney disease in the UK: workload implications for primary care","volume":"105","author":"Hossain","year":"2012","journal-title":"QJM"},{"key":"2021113010512415500_B12","doi-asserted-by":"publisher","first-page":"396","DOI":"10.5935\/0101-2800.20140056","article-title":"Neuropsychiatric disorders and renal diseases: an update","volume":"36","author":"Moreira","year":"2014","journal-title":"J. Bras. Nefrol."},{"key":"2021113010512415500_B13","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S0002-9343(98)00245-9","article-title":"Psychiatric illness in patients with end-stage renal disease","volume":"105","author":"Kimmel","year":"1998","journal-title":"Am. J. Med."},{"key":"2021113010512415500_B14","doi-asserted-by":"publisher","first-page":"484","DOI":"10.2215\/CJN.00040107","article-title":"Depression and anxiety in urban hemodialysis patients","volume":"2","author":"Cukor","year":"2007","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2021113010512415500_B15","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/ncpneph0359","article-title":"Depression in end-stage renal disease hemodialysis patients","volume":"2","author":"Cukor","year":"2006","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"2021113010512415500_B16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/ki.2010.336","article-title":"Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies","volume":"79","author":"Tamura","year":"2011","journal-title":"Kidney Int."},{"key":"2021113010512415500_B17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1681\/ASN.2012050536","article-title":"Cognitive disorders and dementia in CKD: the neglected kidney-brain axis","volume":"24","author":"Bugnicourt","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113010512415500_B18","first-page":"1208","article-title":"Assessment of cognitive dysfunction in kidney disease","volume":"23","author":"Nasser Mel","year":"2012","journal-title":"Saudi. J. Kidney Dis. Transpl."},{"key":"2021113010512415500_B19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4103\/0971-4065.42337","article-title":"Psychiatric issues in renal failure and dialysis","volume":"18","author":"De Sousa","year":"2008","journal-title":"Indian J. Nephrol."},{"key":"2021113010512415500_B20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrneph.2010.83","article-title":"Neuropsychiatric complications of chronic kidney disease","volume":"6","author":"McQuillan","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"2021113010512415500_B21","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1212\/WNL.0b013e31823b4765","article-title":"Chronic kidney disease, cognitive decline, and incident dementia: the 3C Study","volume":"77","author":"Helmer","year":"2011","journal-title":"Neurology"},{"key":"2021113010512415500_B22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1440-1797.2012.01572.x","article-title":"Oxidative stress, anti-oxidant therapies and chronic kidney disease","volume":"17","author":"Small","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"2021113010512415500_B23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1590\/S0101-28002011000300012","article-title":"Inflammation in chronic kidney disease: the role of cytokines","volume":"33","author":"Vianna","year":"2011","journal-title":"J. Bras. Nefrol."},{"key":"2021113010512415500_B24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/ajh\/hpu197","article-title":"Neuroprotective effects of angiotensin receptor blockers","volume":"28","author":"Villapol","year":"2015","journal-title":"Am. J. Hypertens."},{"key":"2021113010512415500_B25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.it.2006.11.004","article-title":"What is immune privilege (not)?","volume":"28","author":"Galea","year":"2007","journal-title":"Trends Immunol."},{"key":"2021113010512415500_B26","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088576-3\/50018-6","article-title":"Expression and action of cytokines in the brain: mechanisms and pathophysiological implications","volume-title":"In Psychoneuroimmunology","author":"Dantzer","year":"2007","edition":"4th edn"},{"key":"2021113010512415500_B27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1742-2094-11-73","article-title":"Peripheral inflammation is associated with remote global gene expression changes in the brain","volume":"11","author":"Thomson","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"2021113010512415500_B28","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/sj.mp.4000813","article-title":"Cytokine signals propagate through the brain","volume":"5","author":"Vitkovic","year":"2000","journal-title":"Mol. Psychiatry"},{"key":"2021113010512415500_B29","first-page":"499","article-title":"Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism","volume":"317","author":"Bluthe","year":"1994","journal-title":"C. R. Acad. Sci. III"},{"key":"2021113010512415500_B30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0006-8993(94)91742-6","article-title":"Neurocircuitry of illness-induced hyperalgesia","volume":"639","author":"Watkins","year":"1994","journal-title":"Brain Res"},{"key":"2021113010512415500_B31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0306-4522(97)00350-3","article-title":"Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide","volume":"83","author":"Quan","year":"1998","journal-title":"Neuroscience"},{"key":"2021113010512415500_B32","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/cne.20052","article-title":"Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli","volume":"472","author":"Konsman","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"2021113010512415500_B33","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1523\/JNEUROSCI.22-13-05606.2002","article-title":"Distinct brain vascular cell types\u00a0manifest inducible cyclooxygenase expression as a function of the strength and nature of immune insults","volume":"22","author":"Schiltz","year":"2002","journal-title":"J. Neurosci."},{"key":"2021113010512415500_B34","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ncl.2006.03.009","article-title":"The blood-brain barrier in psychoneuroimmunology","volume":"24","author":"Banks","year":"2006","journal-title":"Neurol. Clin."},{"key":"2021113010512415500_B35","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"2021113010512415500_B36","first-page":"60","article-title":"Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent? Auton","volume":"85","author":"Dantzer","year":"2000","journal-title":"Neurosci."},{"key":"2021113010512415500_B37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2021113010512415500_B38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","article-title":"Twenty years of research on cytokine-induced sickness behavior","volume":"21","author":"Dantzer","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"2021113010512415500_B39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1242\/jeb.073411","article-title":"Immune\u2013neural connections: how the immune system\u2018s response to infectious agents influences behavior","volume":"216","author":"McCusker","year":"2013","journal-title":"J. Exp. Biol."},{"key":"2021113010512415500_B40","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.2215\/CJN.03500412","article-title":"Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC","volume":"7","author":"Gupta","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2021113010512415500_B41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/978-3-319-09752-7","article-title":"The rs1800471 polymorphism of TGFB1 gene, serum TGF-beta1 level and chronic kidney disease progression","volume":"833","author":"Kilis-Pstrusinska","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"2021113010512415500_B42","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.smim.2013.10.023","article-title":"The interleukin-1 receptor family","volume":"25","author":"Boraschi","year":"2013","journal-title":"Semin. Immunol."},{"key":"2021113010512415500_B43","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0167-4889(02)00320-8","article-title":"Summary and comparison of the signaling mechanisms of the Toll\/interleukin-1 receptor family","volume":"1592","author":"Martin","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"2021113010512415500_B44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cyto.2015.06.017","article-title":"The interleukin (IL)-1 cytokine family\u2013balance between agonists and antagonists in inflammatory diseases","volume":"76","author":"Palomo","year":"2015","journal-title":"Cytokine"},{"key":"2021113010512415500_B45","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1\u00a0in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"2021113010512415500_B46","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1523\/JNEUROSCI.4361-12.2013","article-title":"Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model","volume":"33","author":"Ghosh","year":"2013","journal-title":"J. Neurosci."},{"key":"2021113010512415500_B47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3233\/JPD-130250","article-title":"The role of innate and adaptive immunity in Parkinson's disease","volume":"3","author":"Kannarkat","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"2021113010512415500_B48","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"2021113010512415500_B49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/PSY.0b013e3181907c1b","article-title":"Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis","volume":"71","author":"Howren","year":"2009","journal-title":"Psychosom. Med."},{"key":"2021113010512415500_B50","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6\u00a0in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021113010512415500_B51","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1182\/blood.V86.4.1243.bloodjournal8641243","article-title":"Interleukin-6 family of cytokines and gp130","volume":"86","author":"Kishimoto","year":"1995","journal-title":"Blood"},{"key":"2021113010512415500_B52","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.7150\/ijbs.4679","article-title":"Interleukin-6, a major cytokine in the central nervous system","volume":"8","author":"Erta","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"2021113010512415500_B53","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.brainresrev.2011.01.002","article-title":"Interleukin-6, a mental cytokine","volume":"67","author":"Spooren","year":"2011","journal-title":"Brain Res. Rev."},{"key":"2021113010512415500_B54","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/path.2287","article-title":"TNF-mediated inflammatory disease","volume":"214","author":"Bradley","year":"2008","journal-title":"J. Pathol."},{"key":"2021113010512415500_B55","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/S0140-6736(89)92394-5","article-title":"Cachectin\/tumour necrosis factor","volume":"1","author":"Tracey","year":"1989","journal-title":"Lancet"},{"key":"2021113010512415500_B56","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1067\/msy.2000.101584","article-title":"Inflammatory cytokines and cell response in surgery","volume":"127","author":"Lin","year":"2000","journal-title":"Surgery"},{"key":"2021113010512415500_B57","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","article-title":"TNF-alpha signalling and inflammation: interactions between old acquaintances","volume":"62","author":"Zelova","year":"2013","journal-title":"Inflamm. Res."},{"key":"2021113010512415500_B58","doi-asserted-by":"publisher","first-page":"610813","DOI":"10.1155\/2015\/610813","article-title":"Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2021113010512415500_B59","doi-asserted-by":"publisher","first-page":"861231","DOI":"10.1155\/2014\/861231","article-title":"Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity","volume":"2014","author":"Olmos","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"2021113010512415500_B60","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.drudis.2014.02.006","article-title":"Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease","volume":"19","author":"Sepers","year":"2014","journal-title":"Drug. Discov. Today"},{"key":"2021113010512415500_B61","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00702-013-1149-z","article-title":"A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease","volume":"121","author":"Ambrosi","year":"2014","journal-title":"J. Neural Transm. (Vienna)."},{"key":"2021113010512415500_B62","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2012.11.014","article-title":"Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease","volume":"62","author":"Yan","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"2021113010512415500_B63","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3233\/JAD-121990","article-title":"Slow excitotoxicity in Alzheimer's disease","volume":"35","author":"Ong","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"2021113010512415500_B64","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson's disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"2021113010512415500_B65","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"2021113010512415500_B66","doi-asserted-by":"publisher","first-page":"384","DOI":"10.5603\/EP.2013.0022","article-title":"Transforming growth factor \u03b21 (TGF\u03b21) in physiology and pathology","volume":"64","author":"Kajdaniuk","year":"2013","journal-title":"Endokrynol. Pol."},{"key":"2021113010512415500_B67","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.tins.2011.06.002","article-title":"More than being protective: functional roles for TGF-\u03b2\/activin signaling pathways at central synapses","volume":"34","author":"Krieglstein","year":"2011","journal-title":"Trends Neurosci."},{"key":"2021113010512415500_B68","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.4049\/jimmunol.149.7.2358","article-title":"Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha","volume":"149","author":"Aloisi","year":"1992","journal-title":"J. Immunol."},{"key":"2021113010512415500_B69","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0074-7696(04)37004-X","article-title":"Vertebrate thymus and the neurotrophin system","volume":"237","author":"Vega","year":"2004","journal-title":"Int. Rev. Cytol."},{"key":"2021113010512415500_B70","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/CS20050163","article-title":"Neurotrophin signalling in health and disease","volume":"110","author":"Chao","year":"2006","journal-title":"Clin. Sci. (Lond.)"},{"key":"2021113010512415500_B71","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12017-011-8154-x","article-title":"Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond","volume":"13","author":"Diniz","year":"2011","journal-title":"Neuromolecular Med"},{"key":"2021113010512415500_B72","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.1096\/fj.12-226555","article-title":"Neurotrophic factor expression in expandable cell populations from brain samples in living patients with Parkinson's disease","volume":"27","author":"Xu","year":"2013","journal-title":"FASEB J"},{"key":"2021113010512415500_B73","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nrneurol.2009.54","article-title":"Brain-derived neurotrophic factor in neurodegenerative diseases","volume":"5","author":"Zuccato","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"2021113010512415500_B74","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1615\/CritRevImmunol.v29.i1.20","article-title":"Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination","volume":"29","author":"Linker","year":"2009","journal-title":"Crit. Rev. Immunol."},{"key":"2021113010512415500_B75","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1567205012666150921100030","article-title":"The NGF metabolic pathway in the CNS and its dysregulation in Down syndrome and Alzheimer's disease","volume":"13","author":"Iulita","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"2021113010512415500_B76","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/cdd.2013.22","article-title":"ProNGF\\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice","volume":"20","author":"Tiveron","year":"2013","journal-title":"Cell Death Differ."},{"key":"2021113010512415500_B77","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1006\/mcne.2001.1016","article-title":"The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease","volume":"18","author":"Fahnestock","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"2021113010512415500_B78","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3233\/JAD-150172","article-title":"Decreased neurotrophic support is associated with cognitive decline in non-demented subjects","volume":"46","author":"Forlenza","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"2021113010512415500_B79","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s13760-012-0101-6","article-title":"Serum brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 levels in dementia","volume":"112","author":"Konukoglu","year":"2012","journal-title":"Acta Neurol. Belg."},{"key":"2021113010512415500_B80","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jpsychires.2015.02.004","article-title":"Decreased glial cell line-derived neurotrophic factor levels in patients with depression: a meta-analytic study","volume":"63","author":"Lin","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"2021113010512415500_B81","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/appy.12120","article-title":"Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder","volume":"6","author":"Zhang","year":"2014","journal-title":"Asia Pac. Psychiatry"},{"key":"2021113010512415500_B82","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1006\/jaut.2000.0441","article-title":"Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity","volume":"15","author":"Moalem","year":"2000","journal-title":"J. Autoimmun."},{"key":"2021113010512415500_B83","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0165-5728(97)00055-6","article-title":"Distribution of NGF receptors in normal and pathologic human lymphoid tissues","volume":"77","author":"Labouyrie","year":"1997","journal-title":"J. Neuroimmunol."},{"key":"2021113010512415500_B84","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0092-8674(00)81113-7","article-title":"Nerve growth factor is an autocrine survival factor for memory B lymphocytes","volume":"85","author":"Torcia","year":"1996","journal-title":"Cell"},{"key":"2021113010512415500_B85","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.4088\/JCP.10m06745","article-title":"Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume","volume":"72","author":"Mondelli","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"2021113010512415500_B86","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S0169-409X(98)00086-6","article-title":"Penetration of neurotrophins and cytokines across the blood-brain\/blood-spinal cord barrier","volume":"36","author":"Pan","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2021113010512415500_B87","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0006-8993(97)01525-4","article-title":"Permeability of the blood-brain barrier to neurotrophins","volume":"788","author":"Pan","year":"1998","journal-title":"Brain Res."},{"key":"2021113010512415500_B88","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","article-title":"Transport of brain-derived neurotrophic factor across the blood-brain barrier","volume":"37","author":"Pan","year":"1998","journal-title":"Neuropharmacology"},{"key":"2021113010512415500_B89","doi-asserted-by":"publisher","first-page":"4576012","DOI":"10.1155\/2016\/4576012","article-title":"Blood-Brain barrier disruption induced by chronic sleep loss: low-grade inflammation may be the link","volume":"2016","author":"Hurtado-Alvarado","year":"2016","journal-title":"J. Immunol. Res."},{"key":"2021113010512415500_B90","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3371\/CSRP.FACA.030813","article-title":"Does systemic inflammation play a role in pediatric psychosis? Clin","volume":"9","author":"Falcone","year":"2015","journal-title":"Schizophr. Relat. Psychoses"},{"key":"2021113010512415500_B91","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12979-015-0029-9","article-title":"Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment","volume":"12","author":"Elahy","year":"2015","journal-title":"Immun. Ageing"},{"key":"2021113010512415500_B92","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.lfs.2016.07.020","article-title":"A highly reproducible mice model of chronic kidney disease: evidences of behavioural abnormalities and blood-brain barrier disruption","volume":"161","author":"Mazumder","year":"2016","journal-title":"Life Sci."},{"key":"2021113010512415500_B93","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid","volume":"9","author":"Malhotra","year":"2007","journal-title":"Redox Signal."},{"key":"2021113010512415500_B94","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"2021113010512415500_B95","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"111","author":"Cachofeiro","year":"2008","journal-title":"Kidney Int."},{"key":"2021113010512415500_B96","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"Ruiz","year":"2013","journal-title":"Kidney Int."},{"key":"2021113010512415500_B97","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s11892-013-0372-1","article-title":"Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis","volume":"13","author":"Gupte","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"2021113010512415500_B98","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.1111\/febs.12005","article-title":"Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability","volume":"279","author":"Oh","year":"2012","journal-title":"FEBS J."},{"key":"2021113010512415500_B99","doi-asserted-by":"publisher","first-page":"F662","DOI":"10.1152\/ajprenal.00421.2009","article-title":"Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure","volume":"298","author":"Kim","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2021113010512415500_B100","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1172\/JCI37672","article-title":"Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure","volume":"120","author":"D'Apolito","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2021113010512415500_B101","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1111\/j.1523-1755.2004.00465.x","article-title":"Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease","volume":"65","author":"Oberg","year":"2004","journal-title":"Kidney Int."},{"key":"2021113010512415500_B102","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1111\/jgs.13665","article-title":"Association between cognitive impairment and chronic kidney disease in mexican americans","volume":"63","author":"Szerlip","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021113010512415500_B103","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.atherosclerosis.2015.01.034","article-title":"Urea-induced ROS cause endothelial dysfunction in chronic renal failure","volume":"239","author":"D'Apolito","year":"2015","journal-title":"Atherosclerosis"},{"key":"2021113010512415500_B104","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nrd873","article-title":"Drugs targeting the renin-angiotensin-aldosterone system","volume":"1","author":"Zaman","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021113010512415500_B105","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s00467-011-2002-y","article-title":"The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease","volume":"27","author":"Simoes-e-Silva","year":"2012","journal-title":"Pediatr. Nephrol."},{"key":"2021113010512415500_B106","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.phrs.2016.03.018","article-title":"ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis","volume":"107","author":"Simoes-e-Silva","year":"2016","journal-title":"Pharmacol. Res."},{"key":"2021113010512415500_B107","author":"Prestes","year":"2016"},{"key":"2021113010512415500_B108","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/bph.12159","article-title":"ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis","volume":"169","author":"Simoes-e-Silva","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"2021113010512415500_B109","doi-asserted-by":"publisher","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010512415500_B110","doi-asserted-by":"publisher","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021113010512415500_B111","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"key":"2021113010512415500_B112","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1021\/cn500363g","article-title":"The implications of angiotensin-converting enzymes and their modulators in neurodegenerative disorders: current and future perspectives","volume":"6","author":"Kaur","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"2021113010512415500_B113","doi-asserted-by":"publisher","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease","volume":"14","author":"AbdAlla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"2021113010512415500_B114","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3233\/JAD-131694","article-title":"Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer's disease","volume":"40","author":"O'Caoimh","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"2021113010512415500_B115","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/jnr.20598","article-title":"Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism","volume":"81","author":"Lopez-Real","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"2021113010512415500_B116","doi-asserted-by":"publisher","first-page":"16024","DOI":"10.1038\/npjamd.2016.24","article-title":"Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function","volume":"2","author":"Wang","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"2021113010512415500_B117","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3233\/JAD-150642","article-title":"Intracerebroventricular infusion of angiotensin-(1-7) ameliorates cognitive impairment and memory dysfunction in a mouse model of Alzheimer's disease","volume":"53","author":"Uekawa","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"2021113010512415500_B118","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1042\/CS20160116","article-title":"Anxiolytic- and antidepressant-like effects of angiotensin-(1-7) in hypertensive transgenic (mRen2)27 rats","volume":"130","author":"Almeida-Santos","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"2021113010512415500_B119","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jns.2016.07.031","article-title":"Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson's disease","volume":"368","author":"Rocha","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"2021113010512415500_B120","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/ijcp.12020","article-title":"Association of depression and anxiety with reduced quality of life in patients with predialysis chronic kidney disease","volume":"67","author":"Lee","year":"2013","journal-title":"Int. J. Clin. Practice"},{"key":"2021113010512415500_B121","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.semnephrol.2005.06.012","article-title":"Depression in chronic kidney disease","volume":"26","author":"Fabrazzo","year":"2006","journal-title":"Semin. Nephrol."},{"key":"2021113010512415500_B122","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nrneph.2015.131","article-title":"Kidney-brain crosstalk in the acute and chronic setting","volume":"11","author":"Lu","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"2021113010512415500_B123","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuro.2014.06.014","article-title":"Cerebro-renal interactions: impact of uremic toxins on cognitive function","volume":"44","author":"Watanabe","year":"2014","journal-title":"Neurotoxicology"},{"key":"2021113010512415500_B124","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nrneurol.2009.138","article-title":"Neurological complications of chronic kidney disease","volume":"5","author":"Krishnan","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"2021113010512415500_B125","doi-asserted-by":"publisher","first-page":"306189","DOI":"10.4061\/2011\/306189","article-title":"Clinical interaction between brain and kidney in small vessel disease","volume":"2011","author":"Mogi","year":"2011","journal-title":"Cardiol. Res. Pract."},{"key":"2021113010512415500_B126","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1053\/j.ajkd.2007.03.019","article-title":"High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis","volume":"50","author":"Kim","year":"2007","journal-title":"Am. J. Kidney Dis."},{"key":"2021113010512415500_B127","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1053\/j.ajkd.2005.10.029","article-title":"Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD","volume":"47","author":"Martinez-Vea","year":"2006","journal-title":"Am. J. Kidney Dis."},{"key":"2021113010512415500_B128","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000068034","article-title":"Silent cerebral infarction in hemodialysis patients","volume":"23","author":"Nakatani","year":"2003","journal-title":"Am. J. Nephrol."},{"key":"2021113010512415500_B129","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1161\/01.STR.28.12.2528","article-title":"Cerebral magnetic resonance T2 high intensities in end-stage renal disease","volume":"28","author":"Suzuki","year":"1997","journal-title":"Stroke"},{"key":"2021113010512415500_B130","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1097\/01.ASN.0000131529.60019.FA","article-title":"Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study","volume":"15","author":"Seliger","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113010512415500_B131","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s00467-015-3159-6","article-title":"Anxiety, depression, resilience and quality of life in children and adolescents with pre-dialysis chronic kidney disease","volume":"30","author":"Moreira","year":"2015","journal-title":"Pediatr. Nephrol."},{"key":"2021113010512415500_B132","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3233\/JAD-2010-091552","article-title":"Antihypertensive treatments, cognitive decline, and dementia","volume":"20","author":"Duron","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"2021113010512415500_B133","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2010.483","article-title":"The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report","volume":"80","author":"Levey","year":"2011","journal-title":"Kidney Int."},{"key":"2021113010512415500_B134","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1525-139X.2009.00577.x","article-title":"Guanidino compounds as uremic (neuro)toxins","volume":"22","author":"De Deyn","year":"2009","journal-title":"Semin. Dial."},{"key":"2021113010512415500_B135","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.bbi.2010.10.021","article-title":"Genomic damage in the progression of chronic kidney disease in rats","volume":"25","author":"Hirotsu","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"2021113010512415500_B136","doi-asserted-by":"publisher","first-page":"e0125271","DOI":"10.1371\/journal.pone.0125271","article-title":"Altered KLOTHO and NF-kappaB-TNF-alpha signaling are correlated with nephrectomy-induced cognitive impairment in rats","volume":"10","author":"Degaspari","year":"2015","journal-title":"PLoS One"},{"key":"2021113010512415500_B137","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1445-5994.2011.02538.x","article-title":"Monocyte chemoattractant protein-1 is associated with silent cerebral infarction in patients on haemodialysis","volume":"42","author":"Uchida","year":"2012","journal-title":"Intern. Med. J."},{"key":"2021113010512415500_B138","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/ndt\/gft327","article-title":"Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol","volume":"29","author":"Fujisaki","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"2021113010512415500_B139","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1681\/ASN.V1291892","article-title":"Increased tyrosine nitration of the brain in chronic renal insufficiency: reversal by antioxidant therapy and angiotensin-converting enzyme inhibition","volume":"12","author":"Deng","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113010512415500_B140","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1093\/ndt\/gfv253","article-title":"Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease","volume":"30","author":"Kielstein","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"2021113010512415500_B141","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.lfs.2014.07.032","article-title":"Improvement in spatial memory dysfunction by telmisartan through reduction of brain angiotensin II and oxidative stress in experimental uremic mice","volume":"113","author":"Haruyama","year":"2014","journal-title":"Life Sci."},{"key":"2021113010512415500_B142","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bbr.2012.03.015","article-title":"Inhibition of central angiotensin converting enzyme ameliorates scopolamine induced memory impairment in mice: role of cholinergic neurotransmission, cerebral blood flow and brain energy metabolism","volume":"232","author":"Tota","year":"2012","journal-title":"Behav. Brain Res."},{"key":"2021113010512415500_B143","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/ajh.2010.241","article-title":"Blockade of AT1 receptors protects the blood\u2013brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats","volume":"24","author":"Pelisch","year":"2011","journal-title":"Am. J. hypertens."},{"key":"2021113010512415500_B144","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.108.123612","article-title":"Continuous activation of renin-angiotensin system impairs cognitive function in renin\/angiotensinogen transgenic mice","volume":"53","author":"Inaba","year":"2009","journal-title":"Hypertension"},{"key":"2021113010512415500_B145","doi-asserted-by":"publisher","first-page":"C685","DOI":"10.1152\/ajpcell.00236.2012","article-title":"CREB, NF-\u03baB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells","volume":"304","author":"Shimizu","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2021113010512415500_B146","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1161\/HYPERTENSIONAHA.110.165464","article-title":"Contribution of a nuclear factor-\u03baB binding site to human angiotensinogen promoter activity in renal proximal tubular cells","volume":"57","author":"Acres","year":"2011","journal-title":"Hypertension"}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/131\/11\/1093\/449207\/cs1311093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/131\/11\/1093\/449207\/cs1311093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:32:30Z","timestamp":1692808350000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/131\/11\/1093\/71618\/Kidney-brain-axis-inflammatory-cross-talk-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":146,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20160927","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}