{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:32:58Z","timestamp":1773336778213,"version":"3.50.1"},"reference-count":92,"publisher":"Portland Press Ltd.","issue":"12","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic wall. Thrombospondin-1 (TSP-1; gene Thbs1) is a member of the matricellular protein family important in the control of extracellular matrix (ECM) remodelling. In the present study, the association of serum TSP-1 concentration with AAA progression was assessed in 276 men that underwent repeated ultrasound for a median 5.5 years. AAA growth was negatively correlated with serum TSP-1 concentration (Spearman\u2019s rho \u22120.129, P=0.033). Men with TSP-1 in the highest quartile had a reduced likelihood of AAA growth greater than median during follow-up (OR: 0.40; 95% confidence interval (CI): 0.19\u20130.84, P=0.016, adjusted for other risk factors). Immunohistochemical staining for TSP-1 was reduced in AAA body tissues compared with the relatively normal AAA neck. To further assess the role of TSP-1 in AAA initiation and progression, combined TSP-1 and apolipoprotein deficient (Thbs1\u2212\/\u2212ApoE\u2212\/\u2212, n=20) and control mice (ApoE\u2212\/\u2212, n=20) were infused subcutaneously with angiotensin II (AngII) for 28 days. Following AngII infusion, Thbs1\u2212\/\u2212 ApoE\u2212\/\u2212 mice had larger AAAs by ultrasound (P=0.024) and ex vivo morphometry measurement (P=0.006). The Thbs1\u2212\/\u2212ApoE\u2212\/\u2212 mice also showed increased elastin filament degradation along with elevated systemic levels and aortic expression of matrix metalloproteinase (MMP)-9. Suprarenal aortic segments and vascular smooth muscle cells (VSMCs) isolated from Thbs1\u2212\/\u2212ApoE\u2212\/\u2212 mice showed reduced collagen 3A1 gene expression. Furthermore, Thbs1\u2212\/\u2212ApoE\u2212\/\u2212 mice had reduced aortic expression of low-density lipoprotein (LDL) receptor-related protein 1. Collectively, findings from the present study suggest that TSP-1 deficiency promotes maladaptive remodelling of the ECM leading to accelerated AAA progression.<\/jats:p>","DOI":"10.1042\/cs20160970","type":"journal-article","created":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:25:36Z","timestamp":1491006336000},"page":"1261-1281","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice"],"prefix":"10.1042","volume":"131","author":[{"given":"Smriti\u00a0Murali","family":"Krishna","sequence":"first","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai\u00a0Wang","family":"Seto","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"},{"name":"National Institute of Complementary Medicine (NICM), School of Science and Health, University of Western Sydney, Campbelltown, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roby","family":"Jose","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaze","family":"Li","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Moxon","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Clancy","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David\u00a0J.","family":"Crossman","sequence":"additional","affiliation":[{"name":"Department of Physiology,Faculty of Medical and Health Sciences, Biophysics and Biophotonics Research Group, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Norman","sequence":"additional","affiliation":[{"name":"School of Surgery, University of Western Australia, Perth, WA 6907, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theophilus\u00a0I.","family":"Emeto","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"},{"name":"Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland 4811, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[{"name":"The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia"},{"name":"Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"2021113011013045900_B1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.ATV.0000245819.32762.cb","article-title":"Abdominal aortic aneurysm: pathogenesis and implications for management","volume":"26","author":"Golledge","year":"2006","journal-title":"Arterioscler. 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