{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:47:12Z","timestamp":1791380832589,"version":"4.3.3"},"reference-count":47,"publisher":"Portland Press Ltd.","issue":"7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4,16]]},"abstract":"<jats:p>The purpose of the present study was to develop and perform initial validation of dynamic MRI enhanced with gadoxetic acid as hepatobiliary contrast agent to quantify hepatic perfusion and hepatocyte function in patients with chronic liver disease. Free-breathing, dynamic gadoxetic acid-enhanced MRI was performed at 3.0 T using a 3D time-resolved angiography sequence with stochastic trajectories during 38 min. A dual-input three-compartment model was developed to derive hepatic perfusion and hepatocyte function parameters. Method feasibility was assessed in 23 patients with biopsy-proven chronic liver disease. Parameter analysis could be performed in 21 patients (91%). The hepatocyte function parameters were more discriminant than the perfusion parameters to differentiate between patients with minimal fibrosis (METAVIR F0\u2013F1), intermediate fibrosis (F2\u2013F3) and cirrhosis (F4). The areas under the receiver operating characteristic curves (ROCs) to diagnose significant fibrosis (METAVIR F \u2265 2) were: 0.95 (95% CI: 0.87\u20131; P&amp;lt;0.001) for biliary efflux, 0.88 (95% CI: 0.73\u20131; P&amp;lt;0.01) for sinusoidal backflux, 0.81 (95% CI: 0.61\u20131; P&amp;lt;0.05) for hepatocyte uptake fraction and 0.75 (95% CI: 0.54\u20131; P&amp;lt;0.05) for hepatic perfusion index (HPI), respectively. These initial results in patients with chronic liver diseases show that simultaneous quantification of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity.<\/jats:p>","DOI":"10.1042\/cs20171131","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T16:31:48Z","timestamp":1518539508000},"page":"813-824","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease"],"prefix":"10.1042","volume":"132","author":[{"given":"Benjamin","family":"Leporq","sequence":"first","affiliation":[{"name":"Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 Inserm - University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Universit\u00e9 de Lyon, CREATIS; CNRS UMR 5220; Inserm U1206; INSA-Lyon; Universit\u00e9 Lyon 1; Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Daire","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 Inserm - University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine\u00a0M.","family":"Pastor","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 Inserm - University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"D\u00e9partement d\u2019Imagerie et des Sciences de l\u2019Information M\u00e9dicale, H\u00f4pitaux Universitaires de Gen\u00e8ve, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Deltenre","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sempoux","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard\u00a0E.","family":"Van Beers","sequence":"additional","affiliation":[{"name":"Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 Inserm - University Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Department of Radiology, Beaujon University Hospital Paris Nord, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"2021113011000319600_B1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"2021113011000319600_B2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1056\/NEJM200102153440706","article-title":"Liver biopsy","volume":"344","author":"Bravo","year":"2001","journal-title":"N. 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