{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:40:57Z","timestamp":1788932457744,"version":"build-2803163510"},"reference-count":44,"publisher":"Portland Press Ltd.","issue":"24","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:p>Arterial stiffness is an independent indicator of cardiovascular risk. Autoantibodies (AAs) against angiotensin AT1 receptor (AT1-AAs) and \u03b11-adrenergic receptor (\u03b11-AAs) are important in the pathogenesis of hypertension. We identified the types of AT1-AAs and \u03b11-AAs in normotensive subjects, with the aim of determining whether these antibodies predict aortic stiffness progression. Carotid\u2013femoral pulse wave velocity (cf-PWV) was used to measure aortic stiffness. Overall, 816 subjects (71% of those invited) underwent a medical examination and evaluation of aortic stiffness. The types of AT1-AAs and \u03b11-AAs were measured at baseline. Meanwhile, plasma renin, angiotensin II (Ang II), and norepinephrine (NE) concentrations were measured at baseline and follow-up. Baseline mean cf-PWV was 9.90 \u00b1 0.84 m\/s and follow-up was 10.51 \u00b1 1.12 m\/s. The annualized \u0394PWV was 0.12 \u00b1 0.08 m\/s\/year. At the end of follow-up, 129 normotensive subjects developed hypertension and 144 subjects had PWV progression. After adjustment for covariates, AA type was independently associated with \u0394PWV, annualized \u0394PWV, and abnormal PWV. In our study, the risk of developing hypertension (RR =2.028, 95% CI: 1.227\u20133.351, P=0.006) and PWV progression (RR =2.910, 95% CI: 1.612\u20135.253, P&amp;lt;0.001) in AA-positive subjects was significantly higher than that in AA-negative subjects. Receiver operating characteristic (ROC) curve showed AA had an identify power to discriminate subjects with or without PWV and hypertension progression. We have shown for the first time that the types of A1-AAs and \u03b11-AAs are independent predictors for aortic stiffness progression in normotensive subjects. Our data collectively support the utility of these AAs as potential markers of aortic stiffness.<\/jats:p>","DOI":"10.1042\/cs20171305","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:21:52Z","timestamp":1509668512000},"page":"2947-2957","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Autoantibodies against AT1 and \u03b11-adrenergic receptors predict arterial stiffness progression in normotensive subjects over a 5-year period"],"prefix":"10.1042","volume":"131","author":[{"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China"},{"name":"Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Central Hospital of Wuhan, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tong Ji Hospital, Tong Ji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-kun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China"},{"name":"Hepatology Department, Institute of Hepatology, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China"},{"name":"Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Emergency Department, Wuhan General Hospital of Guangzhou Military Command, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-chao","family":"Tu","sequence":"additional","affiliation":[{"name":"Emergency Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China"},{"name":"Teaching and Research Section of Medicine, Hubei Province Academy of Traditional Chinese Medicine, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"2021113010564201900_B1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1161\/01.HYP.37.5.1236","article-title":"Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients","volume":"37","author":"Laurent","year":"2001","journal-title":"Hypertension"},{"key":"2021113010564201900_B2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jacc.2009.10.061","article-title":"Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis","volume":"55","author":"Vlachopoulos","year":"2010","journal-title":"J. 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