{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:10:43Z","timestamp":1791839443810,"version":"4.3.4"},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:p>Fatty acids (FA) are critical for fetal brain development and are transferred across the placenta by membrane-bound FA transport proteins (FATP), translocases (FAT\/CD36), and cytosolic binding proteins (FABP). The cytosolic protein perilipin-2 aids in neutral lipid storage within lipid droplets. Decreased placental nutrient transport is believed to contribute to intrauterine growth restriction (IUGR); however, IUGR placental lipid transport and metabolism are poorly understood. We hypothesized that protein expression of FATPs, FABPs, and perilipin-2 in human placenta is decreased and placental lipid content and incorporation into lipid classes are reduced in IUGR. Placental tissue of idiopathic IUGR (n=25) and gestational age-matched, appropriately grown for gestational age (AGA) fetuses (n=19) was collected. We determined protein expression of FABP4 and perilipin-2 in placental homogenate and FATPs (2, 4, 6, CD36) in syncytiotrophoblast microvillous plasma membrane (MVM) by Western blot. Lipid droplet area (Oil Red O stain) and cellular FA content (GC\/MS) were measured in chorionic villous tissue. MVM expression of FATP6 and CD36 was significantly increased in IUGR. The concentrations of seven n\u22126 and n\u22123 species long chain polyunsaturated FAs (LCPUFA) were significantly increased in the triglyceride fraction in IUGR vs AGA placenta. In summary, MVM FATP6 and CD36 protein expression is increased and LCPUFA are preferentially routed toward cellular storage in TG in the IUGR placenta, possibly to protect against oxidative stress associated with cellular FA accumulation. We speculate that these changes may be caused by impaired efflux of FA across the fetal-facing syncytiotrophoblast basal plasma membrane in IUGR placenta.<\/jats:p>","DOI":"10.1042\/cs20171340","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T20:35:15Z","timestamp":1519158915000},"page":"595-607","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction"],"prefix":"10.1042","volume":"132","author":[{"given":"Stephanie\u00a0Skuby","family":"Chassen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Ferchaud-Roucher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhulika\u00a0B.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Research Institute, University of Western Ontario, London, ON, Canada"},{"name":"Department of Pediatrics and Biochemistry, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa\u00a0L.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO, U.S.A."},{"name":"Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"issue":"Suppl A","key":"2021113011040422700_B1","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/j.placenta.2005.11.010","article-title":"Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? 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