{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:57:34Z","timestamp":1782997054083,"version":"3.54.5"},"reference-count":142,"publisher":"Portland Press Ltd.","issue":"22","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:p>Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing societies, and will increase with an aging and increasingly sedentary society. Vascular disease and atherosclerotic vascular syndromes are essentially inflammatory disorders, and transcriptional and post-transcriptional processes play essential roles in the ability of resident vascular and inflammatory cells to adapt to environmental stimuli. The regulation of mRNA translocation, stability, and translation are key processes of post-transcriptional regulation that permit these cells to rapidly respond to inflammatory stimuli. For the most part, these processes are controlled by elements in the 3\u2032-UTR of labile, proinflammatory transcripts. Since proinflammatory transcripts almost exclusively contain AU-rich elements (AREs), this represents a tightly regulated and specific mechanism for initiation and maintenance of the proinflammatory phenotype. RNA-binding proteins (RBPs) recognize cis elements in 3\u2032-UTR, and regulate each of these processes, but there is little literature exploring the concept that RBPs themselves can be directly regulated by inflammatory stimuli. Conceptually, inflammation-responsive RBPs represent an attractive target of rational therapies to combat vascular inflammatory syndromes. Herein we briefly describe the cellular and molecular etiology of atherosclerosis, and summarize our current understanding of RBPs and their specific roles in regulation of inflammatory mRNA stability. We also detail RBPs as targets of current anti-inflammatory modalities and how this may translate into better treatment for vascular inflammatory diseases.<\/jats:p>","DOI":"10.1042\/cs20171373","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T01:10:23Z","timestamp":1510017023000},"page":"2687-2699","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases"],"prefix":"10.1042","volume":"131","author":[{"given":"Allison\u00a0B.","family":"Herman","sequence":"first","affiliation":[{"name":"Department of Physiology, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0V.","family":"Autieri","sequence":"additional","affiliation":[{"name":"Department of Physiology, Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"2021113010543599400_B1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"2021113010543599400_B2","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nri1882","article-title":"The immune response in atherosclerosis: a double-edged sword","volume":"6","author":"Hansson","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2021113010543599400_B3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/01.ATV.13.2.197","article-title":"An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium","volume":"13","author":"Li","year":"1993","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010543599400_B4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI11871","article-title":"A major role for VCAM-1, but not ICAM-1, in early atherosclerosis","volume":"107","author":"Cybulsky","year":"2001","journal-title":"J. Clin. Invest."},{"key":"2021113010543599400_B5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2165\/00003495-200464002-00005","article-title":"Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial\u2013Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial","volume":"64","author":"Sever","year":"2004","journal-title":"Drugs"},{"key":"2021113010543599400_B6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/CIRCRESAHA.110.233841","article-title":"Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-B regulation that promotes arterial inflammation","volume":"108","author":"Cuhlmann","year":"2011","journal-title":"Circ. Res."},{"key":"2021113010543599400_B7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2021113010543599400_B8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.110.237420","article-title":"Microparticles from human atherosclerotic plaques promote endothelial ICAM-1-dependent monocyte adhesion and transendothelial migration","volume":"108","author":"Rautou","year":"2011","journal-title":"Circ. Res."},{"key":"2021113010543599400_B9","doi-asserted-by":"crossref","first-page":"eaag3009","DOI":"10.1126\/science.aag3009","article-title":"Mapping the human DC lineage through the integration of high-dimensional techniques","volume":"356","author":"See","year":"2017","journal-title":"Science"},{"key":"2021113010543599400_B10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature20611","article-title":"Identification of an atypical monocyte and committed progenitor involved in fibrosis","volume":"541","author":"Satoh","year":"2016","journal-title":"Nature"},{"key":"2021113010543599400_B11","doi-asserted-by":"crossref","first-page":"aaf4238","DOI":"10.1126\/science.aaf4238","article-title":"Specification of tissue-resident macrophages during organogenesis","volume":"353","author":"Mass","year":"2016","journal-title":"Science"},{"key":"2021113010543599400_B12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat. Med."},{"key":"2021113010543599400_B13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/ATVBAHA.114.304029","article-title":"Cholesterol loading reprograms the microRNA-143\/145\u2013myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype significance","volume":"35","author":"Vengrenyuk","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010543599400_B14","doi-asserted-by":"crossref","first-page":"49982","DOI":"10.1074\/jbc.M209649200","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/jlb.67.5.591","article-title":"The role of inflammation in vascular diseases","volume":"67","author":"Sullivan","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"2021113010543599400_B16","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/ATVBAHA.109.191197","article-title":"Liver x receptor signaling pathways and atherosclerosis","volume":"30","author":"Calkin","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010543599400_B17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.aogh.2013.12.001","article-title":"Regression of atherosclerosis: insights from animal and clinical studies","volume":"80","author":"Feig","year":"2014","journal-title":"Ann. Glob. Health"},{"key":"2021113010543599400_B18","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1172\/JCI44925","article-title":"CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice","volume":"121","author":"Weber","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2021113010543599400_B19","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI61758","article-title":"Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis","volume":"122","author":"Koltsova","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2021113010543599400_B20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-pathol-020712-163936","article-title":"The influence of innate and adaptive immune responses on atherosclerosis","volume":"9","author":"Witztum","year":"2014","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"2021113010543599400_B21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev.ph.57.030195.004043","article-title":"Cell biology of atherosclerosis","volume":"57","author":"Ross","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"2021113010543599400_B22","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1194\/jlr.R500004-JLR200","article-title":"Thematic review series: the immune system and atherogenesis. Cytokines affecting endothelial and smooth muscle cells in vascular disease","volume":"46","author":"Raines","year":"2005","journal-title":"J. Lipid Res."},{"key":"2021113010543599400_B23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/pr.55.1.5","article-title":"Interleukins in atherosclerosis: molecular pathways and therapeutic potential","volume":"55","author":"von der Th\u00fcsen","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"2021113010543599400_B24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1749-6632.1997.tb51996.x","article-title":"Molecular determinants of atherosclerotic plaque vulnerability","volume":"811","author":"Libby","year":"1997","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"2021113010543599400_B25","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/ATVBAHA.107.159327","article-title":"Role of smooth muscle cells in the initiation and early progression of atherosclerosis","volume":"28","author":"Doran","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021113010543599400_B26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(05)89001-7","article-title":"Posttranscriptional mechanisms regulating the inflammatory response","volume":"89","author":"Stoecklin","year":"2006","journal-title":"Adv. Immunol."},{"key":"2021113010543599400_B27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.atherosclerosis.2010.08.077","article-title":"Serum uric acid levels predict the severity and morphology of coronary atherosclerosis detected by multidetector computed tomography","volume":"213","author":"Kaya","year":"2010","journal-title":"Atherosclerosis"},{"key":"2021113010543599400_B28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ni1584","article-title":"Post-transcriptional control of cytokine production","volume":"9","author":"Anderson","year":"2008","journal-title":"Nat. Immunol."},{"key":"2021113010543599400_B29","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1042\/bst0300952","article-title":"AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors","volume":"30","author":"Zhang","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"2021113010543599400_B30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bss0700095","article-title":"Control of the expression of inflammatory response genes","volume":"70","author":"Saklatvala","year":"2003","journal-title":"Biochem. Soc. Symp."},{"key":"2021113010543599400_B31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1023\/A:1020992418511","article-title":"MRNA stability and the control of gene expression: implications for human disease","volume":"27","author":"Hollams","year":"2002","journal-title":"Neurochem. Res."},{"key":"2021113010543599400_B32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/wrna.1","article-title":"Inflammation: cytokines and RNA-based regulation","volume":"1","author":"Stumpo","year":"2010","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2021113010543599400_B33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.biolcel.2004.05.002","article-title":"Post-transcriptional regulation in cancer","volume":"96","author":"Audic","year":"2004","journal-title":"Biol. Cell"},{"key":"2021113010543599400_B34","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2884","article-title":"Post-transcriptional coordination of immunological responses by RNA-binding proteins","volume":"15","author":"Kafasla","year":"2014","journal-title":"Nat. Immunol."},{"key":"2021113010543599400_B35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tcm.2015.02.006","article-title":"RNA-stabilizing proteins as molecular targets in cardiovascular pathologies","volume":"25","author":"Suresh Babu","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"2021113010543599400_B36","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1016\/S0021-9258(18)49970-X","article-title":"The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs","volume":"266","author":"Gillis","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B37","doi-asserted-by":"crossref","first-page":"D111","DOI":"10.1093\/nar\/gkj052","article-title":"ARED 3.0: the large and diverse AU-rich transcriptome","volume":"34","author":"Bakheet","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2021113010543599400_B38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0968-0004(00)89102-1","article-title":"AU-rich elements: characterization and importance in mRNA degradation","volume":"20","author":"Chen","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"2021113010543599400_B39","first-page":"7984","article-title":"AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U\/A)(U\/A)","volume":"14","author":"Lagnado","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2021113010543599400_B40","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1182\/blood.V83.11.3182.3182","article-title":"Number and location of AUUUA motifs: role in regulating transiently expressed RNAs","volume":"83","author":"Akashi","year":"1994","journal-title":"Blood"},{"key":"2021113010543599400_B41","doi-asserted-by":"crossref","first-page":"27183","DOI":"10.1074\/jbc.M202883200","article-title":"Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3\u2032-untranslated region of the androgen receptor messenger RNA","volume":"277","author":"Yeap","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B42","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/ijc.20675","article-title":"IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3\u2032 untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR","volume":"113","author":"Suswam","year":"2005","journal-title":"Int. J. Cancer"},{"key":"2021113010543599400_B43","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0092-8674(86)90341-7","article-title":"A conserved AU sequence from the 3\u2032 untranslated region of GM-CSF mRNA mediates selective mRNA degradation","volume":"46","author":"Shaw","year":"1986","journal-title":"Cell"},{"key":"2021113010543599400_B44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"2021113010543599400_B45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni.1699","article-title":"The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules","volume":"10","author":"Hao","year":"2009","journal-title":"Nat. Immunol."},{"key":"2021113010543599400_B46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0962-8924(01)02225-5","article-title":"The yin and yang of the exosome","volume":"12","author":"Butler","year":"2002","journal-title":"Trends Cell Biol."},{"key":"2021113010543599400_B47","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0092-8674(01)00578-5","article-title":"AU binding proteins recruit the exosome to degrade ARE-containing mRNAs","volume":"107","author":"Chen","year":"2001","journal-title":"Cell"},{"key":"2021113010543599400_B48","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1371\/journal.pbio.0050005","article-title":"The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling","volume":"5","author":"Gherzi","year":"2006","journal-title":"PLoS Biol."},{"key":"2021113010543599400_B49","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ni0309-233","article-title":"Intrinsic mRNA stability helps compose the inflammatory symphony","volume":"10","author":"Anderson","year":"2009","journal-title":"Nat. Immunol."},{"key":"2021113010543599400_B50","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1038\/sj.emboj.7600305","article-title":"Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs","volume":"23","author":"Lal","year":"2004","journal-title":"EMBO J."},{"key":"2021113010543599400_B51","doi-asserted-by":"crossref","first-page":"19185","DOI":"10.1016\/S0021-9258(17)30642-7","article-title":"A growth factor-inducible nuclear protein with a novel cysteine\/histidine repetitive sequence","volume":"265","author":"DuBois","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B52","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.281.5379.1001","article-title":"Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin","volume":"281","author":"Carballo","year":"1998","journal-title":"Science"},{"key":"2021113010543599400_B53","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/sj.emboj.7600163","article-title":"MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay","volume":"23","author":"Stoecklin","year":"2004","journal-title":"EMBO J."},{"key":"2021113010543599400_B54","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1128\/MCB.26.6.2399-2407.2006","article-title":"Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine\/uridine-rich element","volume":"26","author":"Hitti","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2021113010543599400_B55","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4049\/jimmunol.1402830","article-title":"Dual-specificity phosphatase 1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide","volume":"195","author":"Smallie","year":"2015","journal-title":"J. Immunol."},{"key":"2021113010543599400_B56","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1073\/pnas.1519906113","article-title":"Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies","volume":"113","author":"Patial","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021113010543599400_B57","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.febslet.2009.04.039","article-title":"The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages","volume":"583","author":"Tudor","year":"2009","journal-title":"FEBS Lett."},{"key":"2021113010543599400_B58","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V95.6.1891","article-title":"Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability","volume":"95","author":"Carballo","year":"2000","journal-title":"Blood"},{"key":"2021113010543599400_B59","first-page":"1578","article-title":"Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements","volume":"7","author":"Stoecklin","year":"2001","journal-title":"RNA"},{"key":"2021113010543599400_B60","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1158\/0008-5472.CAN-07-2751","article-title":"Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells","volume":"68","author":"Suswam","year":"2008","journal-title":"Cancer Res."},{"key":"2021113010543599400_B61","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1038\/sj.onc.1209645","article-title":"Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling","volume":"25","author":"Marderosian","year":"2006","journal-title":"Oncogene"},{"key":"2021113010543599400_B62","doi-asserted-by":"crossref","first-page":"23144","DOI":"10.1074\/jbc.M100680200","article-title":"Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail","volume":"276","author":"Lai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B63","doi-asserted-by":"crossref","first-page":"953","DOI":"10.4049\/jimmunol.174.2.953","article-title":"Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay","volume":"174","author":"Ogilvie","year":"2005","journal-title":"J. Immunol."},{"key":"2021113010543599400_B64","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.4049\/jimmunol.180.4.2545","article-title":"Tristetraprolin regulates CXCL1 (KC) mRNA stability","volume":"180","author":"Datta","year":"2008","journal-title":"J. Immunol."},{"key":"2021113010543599400_B65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.772947","article-title":"The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome","author":"Haneklaus","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B66","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1261\/rna.2254110","article-title":"Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: focus on hnRNP E1\u2019s multifunctional regulatory roles","volume":"16","author":"Chaudhury","year":"2010","journal-title":"RNA"},{"key":"2021113010543599400_B67","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1194\/jlr.M800375-JLR200","article-title":"Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements","volume":"50","author":"Li","year":"2009","journal-title":"J. Lipid Res."},{"key":"2021113010543599400_B68","first-page":"7652","article-title":"Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1","volume":"13","author":"Zhang","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"2021113010543599400_B69","doi-asserted-by":"crossref","first-page":"33973","DOI":"10.1074\/jbc.274.48.33973","article-title":"Developmental regulation of RNA transcript destabilization by A + U-rich elements is AUF1-dependent","volume":"274","author":"Buzby","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2021113010543599400_B70","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1089\/jir.2008.0028","article-title":"AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes","volume":"28","author":"Sarkar","year":"2008","journal-title":"J. Interferon Cytokine Res."},{"key":"2021113010543599400_B71","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1101\/gad.1467606","article-title":"Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs","volume":"20","author":"Lu","year":"2006","journal-title":"Genes Dev."},{"key":"2021113010543599400_B72","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/jid.2008.298","article-title":"Auf1\/Hnrnpd-deficient mice develop pruritic inflammatory skin disease","volume":"129","author":"Sadri","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"2021113010543599400_B73","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1083\/jcb.147.7.1431","article-title":"RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules","volume":"147","author":"Kedersha","year":"1999","journal-title":"J. Cell Biol."},{"key":"2021113010543599400_B74","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1093\/emboj\/19.15.4154","article-title":"TIA-1 is a translational silencer that selectively regulates the expression of TNF-\u03b1","volume":"19","author":"Piecyk","year":"2000","journal-title":"EMBO J."},{"key":"2021113010543599400_B75","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.20030616","article-title":"Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1","volume":"198","author":"Dixon","year":"2003","journal-title":"J. Exp. Med."},{"key":"2021113010543599400_B76","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1073\/pnas.0400148101","article-title":"Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor \u03b1, cyclooxygenase 2, and inflammatory arthritis","volume":"101","author":"Phillips","year":"2004","journal-title":"Proc. Natl. Acad. Sci. 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Chem."},{"key":"2021113010543599400_B83","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1111\/j.1742-4658.2010.07692.x","article-title":"Fragile X-related protein FXR1 controls post-transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-alpha production by transforming growth factor-beta1","volume":"277","author":"Khera","year":"2010","journal-title":"FEBS J."},{"key":"2021113010543599400_B84","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/glia.22396","article-title":"KSRP: a checkpoint for inflammatory cytokine production in astrocytes","volume":"60","author":"Li","year":"2012","journal-title":"Glia"},{"key":"2021113010543599400_B85","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/nar\/gki797","article-title":"Involvement of KSRP in the post-transcriptional regulation of human iNOS expression\u2013complex interplay of KSRP with TTP and HuR","volume":"33","author":"Linker","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2021113010543599400_B86","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1073\/pnas.0407523102","article-title":"The RNA-binding protein HuD regulates neuronal cell identity and maturation","volume":"102","author":"Akamatsu","year":"2005","journal-title":"Proc. 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Engl."},{"key":"2021113010543599400_B106","doi-asserted-by":"crossref","first-page":"24599","DOI":"10.18632\/oncotarget.5248","article-title":"Quaking and miR-155 interactions in inflammation and leukemogenesis","volume":"6","author":"Tili","year":"2015","journal-title":"Oncotarget"},{"key":"2021113010543599400_B107","doi-asserted-by":"crossref","first-page":"2030.e3","DOI":"10.1053\/j.gastro.2008.08.009","article-title":"NF-\u03baB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis","volume":"135","author":"Kang","year":"2008","journal-title":"Gastroenterology"},{"key":"2021113010543599400_B108","doi-asserted-by":"crossref","first-page":"494.7","DOI":"10.1096\/fasebj.24.1_supplement.494.7","article-title":"Role of RNA-binding protein HuR and CUGBP1 in LPS-induced interleukin-6 expression in macrophages","volume":"24","author":"Zha","year":"2010","journal-title":"FASEB J."},{"key":"2021113010543599400_B109","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2011.00007","article-title":"Post-transcriptional control of the hypoxic response by RNA-Binding proteins and microRNAs","volume":"4","author":"Gorospe","year":"2011","journal-title":"Front. 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