{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:43:35Z","timestamp":1774323815251,"version":"3.50.1"},"reference-count":65,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>Abdominal obesity and\/or a high intake of fructose may cause hypertension. K+ channels, Na\/K-ATPase, and voltage-gated Ca2+ channels are crucial determinants of resistance artery tone and thus the control of blood pressure. Limited information is available on the role of K+ transporters in long-term diet-induced hypertension in rats. We hypothesized that a 28-week diet rich in fat, fructose, or both, will lead to changes in K+ transporter expression and function, which is associated with increased blood pressure and decreased arterial function. Male Sprague\u2013Dawley (SD) rats received a diet containing normal chow (Control), high-fat chow (High Fat), high-fructose in drinking water (High Fructose), or a combination of high-fat and high-fructose diet (High Fat\/Fruc) for 28 weeks from the age of 4 weeks. Measurements included body weight (BW), systolic blood pressure (SBP), mRNA expression of vascular K+ transporters, and vessel myography in small mesenteric arteries (SMAs). BW was increased in the High Fat and High Fat\/Fruc groups, and SBP was increased in the High Fat\/Fruc group. mRNA expression of small conductance calcium-activated K+ channel (SKCa), intermediate conductance calcium-activated K+ (IKCa), and Kir2.1 inward rectifier K+ channels were reduced in the High Fat\/Fruc group. Reduced endothelium-derived hyperpolarization (EDH)-type relaxation to acetylcholine (ACh) was seen in the High Fat and High Fat\/Fruc groups. Ba2+-sensitive dilatation to extracellular K+ was impaired in all the experimental diet groups. In conclusion, reduced expression and function of SKCa, IKCa, and Kir2.1 channels are associated with elevated blood pressure in rats fed a long-term High Fat\/Fruc. Rats fed a 28-week High Fat\/Fruc provide a relevant model of diet-induced hypertension.<\/jats:p>","DOI":"10.1042\/cs20171408","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T10:04:53Z","timestamp":1518084293000},"page":"461-474","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Long-term diet-induced hypertension in rats is associated with reduced expression and function of small artery SKCa, IKCa, and Kir2.1 channels"],"prefix":"10.1042","volume":"132","author":[{"given":"Anna K.J.","family":"Gradel","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Salomonsson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Medical Ward 12, Trelleborg Hospital, Trelleborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte\u00a0M.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels-Henrik","family":"Holstein-Rathlou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars\u00a0J\u00f8rn","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"2021113010565902800_B1","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1136\/heart.89.9.1104","article-title":"Cardiac and vascular pathophysiology in hypertension","volume":"89","author":"Mayet","year":"2003","journal-title":"Heart"},{"key":"2021113010565902800_B2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/10739680590896072","article-title":"Potassium channels in the peripheral microcirculation","volume":"12","author":"Jackson","year":"2005","journal-title":"Microcirculation"},{"key":"2021113010565902800_B3","doi-asserted-by":"publisher","first-page":"F505","DOI":"10.1152\/ajprenal.00052.2011","article-title":"Role of vascular potassium channels in the regulation of renal hemodynamics","volume":"302","author":"Sorensen","year":"2012","journal-title":"Am. 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