{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:31:17Z","timestamp":1792042277971,"version":"4.4.0"},"reference-count":118,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":552,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1,31]]},"abstract":"<jats:p>Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+, and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active transcriptional modifier when bound to the mineralocorticoid receptor (MR) in cells expressing the enzyme 11\u03b2-hydroxysteroid dehydrogenase 2, such as those comprising the aldosterone-sensitive distal nephron (ASDN). One such up-regulated protein, the ubiquitous serum and glucocorticoid regulated kinase 1 (SGK1), has the capacity to modulate the surface expression and function of many classes of renal ion channels, including those that transport Na+ (ENaC), K+ (ROMK\/BK), Ca2+ (TRPV4\/5\/6), Mg2+ (TRPM7\/6), and Cl\u2212 (ClC-K, CFTR). Here, we discuss the mechanisms by which ASDN expressed channels are up-regulated by SGK1, while highlighting newly discovered pathways connecting aldosterone to nonselective cation channels that are permeable to Mg2+ (TRPM7) or Ca2+ (TRPV4).<\/jats:p>","DOI":"10.1042\/cs20171525","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T01:11:11Z","timestamp":1516410671000},"page":"173-183","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Aldosterone, SGK1, and ion channels in the kidney"],"prefix":"10.1042","volume":"132","author":[{"given":"William\u00a0C.","family":"Valinsky","sequence":"first","affiliation":[{"name":"Department of Physiology, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0B1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian\u00a0M.","family":"Touyz","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF GCRC, 126 University Place, Glasgow G12 8TA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Shrier","sequence":"additional","affiliation":[{"name":"Department of Physiology, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0B1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"2021113011015891500_B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines","author":"Whelton","year":"2017","journal-title":"J. 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