{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:19:23Z","timestamp":1759961963386},"reference-count":31,"publisher":"Portland Press Ltd.","issue":"20","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>In a recent issue of Clinical Science, Prieto-Vicente et al. [Clin. Sci. (2018) 132, 985\u20131001] have smartly demonstrated a potential new use of cardiotrophin-1 (CT-1) to treat and palliate an inflammatory bowel disease such as ulcerative colitis. In that work, authors report that in ulcerative colitic mice, administration of exogenous recombinant CT-1 (rCT-1) promotes lower colon damage and lower disease activity index, reducing systemic levels of tumor necrosis factor \u03b1 (TNF-\u03b1) and also diminishing TNF-\u03b1 expression in colon together with the reduction in other common inflammation markers. Besides, in vivo rCT-1 administration induces activation of several molecular pathways, including nuclear factor \u03ba-light-chain-enhancer of activated B cells (NF-\u03baB) and signal transducer and activator of transcription (STAT)-3, and abolishes bacterial translocation from intestine to other organs, including mesenteric ganglia, lungs, and spleen. Additionally, these results were nicely corroborated in CT-1 depleted mice; in which colon damage and ulcerative colitis severity were greater compared with the wild-type counterparts. All together, these results suggested that CT-1 could be a promising new therapeutic approach for treating inflammatory bowel disease, particularly ulcerative colitis. However, further studies are required to determine its major mechanisms of action and the potential efficacy of CT-1 in human inflammatory bowel diseases.<\/jats:p>","DOI":"10.1042\/cs20171626","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T12:54:46Z","timestamp":1539953686000},"page":"2169-2174","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential clinical treatment of colitis with cardiotrophin-1"],"prefix":"10.1042","volume":"132","author":[{"given":"Xavier","family":"Escot\u00e9","sequence":"first","affiliation":[{"name":"University of Navarra, Department of Nutrition, Food Science and Physiology, Edificio de Investigaci\u00f3n, C\/Irunlarrea 1, Pamplona 31008, Spain"},{"name":"University of Navarra, Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, Edificio de Investigaci\u00f3n, C\/Irunlarrea 1, Pamplona 31008, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"2021113011042548000_B1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.cytogfr.2015.07.009","article-title":"Cardiotrophin-1: a multifaceted cytokine","volume":"26","author":"L\u00f3pez-Yoldi","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"2021113011042548000_B2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1042\/CS20171513","article-title":"Cardiotrophin-1 attenuates experimental colitis in mice","volume":"132","author":"Prieto-Vicente","year":"2018","journal-title":"Clin. Sci."},{"key":"2021113011042548000_B3","doi-asserted-by":"publisher","first-page":"pii: E1770","DOI":"10.3390\/ijms18081770","article-title":"Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV\/CCN3 in obesity and diabetes development","volume":"18","author":"Escot\u00e9","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2021113011042548000_B4","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cmet.2011.05.013","article-title":"Cardiotrophin-1 is a key regulator of glucose and lipid metabolism","volume":"14","author":"Moreno-Aliaga","year":"2011","journal-title":"Cell Metab."},{"key":"2021113011042548000_B5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0016-5085(03)00698-X","article-title":"Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor upregulated in the regenerating liver in rats","volume":"125","author":"Bustos","year":"2003","journal-title":"Gastroenterology"},{"key":"2021113011042548000_B6","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1084\/jem.20061421","article-title":"Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning","volume":"203","author":"I\u00f1iguez","year":"2006","journal-title":"J. Exp. Med."},{"key":"2021113011042548000_B7","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.jhep.2013.12.012","article-title":"Cardiotrophin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK activation","volume":"60","author":"Casta\u00f1o","year":"2014","journal-title":"J. Hepatol."},{"key":"2021113011042548000_B8","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1016\/j.jss.2012.07.046","article-title":"Cardiotrophin-1 reduces ischemia\/ reperfusion injury during liver transplant","volume":"181","author":"Aguilar-Melero","year":"2013","journal-title":"J. Surg. Res."},{"key":"2021113011042548000_B9","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fimmu.2016.00163","article-title":"STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation - the case of experimental acetaminophen (paracetamol)-induced liver damage","volume":"7","author":"M\u00fchl","year":"2016","journal-title":"Front. Immunol."},{"key":"2021113011042548000_B10","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021113011042548000_B11","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1001\/jama.2016.16885","article-title":"US spending on personal health care and public health, 1996\u20132013","volume":"316","author":"Dieleman","year":"2016","journal-title":"JAMA"},{"key":"2021113011042548000_B12","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/gut.40.4.443","article-title":"Tumour necrosis factor and Crohn\u2019s disease","volume":"40","author":"Van Deventer","year":"1997","journal-title":"Gut"},{"key":"2021113011042548000_B13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11938-018-0175-1","article-title":"Novel therapies and treatment strategies for patients with inflammatory bowel disease","volume":"16","author":"Duijvestein","year":"2018","journal-title":"Curr. Treat. Opt. Gastroenterol."},{"key":"2021113011042548000_B14","doi-asserted-by":"publisher","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021113011042548000_B15","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1097\/BOR.0000000000000337","article-title":"The role of myokines in muscle health and disease","volume":"28","author":"Lightfoot","year":"2016","journal-title":"Curr. Opin. Rheumatol."},{"key":"2021113011042548000_B16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cyto.2014.12.024","article-title":"The varying faces of IL-6: from cardiac protection to cardiac failure","volume":"74","author":"Fontes","year":"2015","journal-title":"Cytokine"},{"key":"2021113011042548000_B17","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1161\/HYPERTENSIONAHA.112.194407","article-title":"Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction","volume":"60","author":"L\u00f3pez-Andr\u00e9s","year":"2012","journal-title":"Hypertension"},{"key":"2021113011042548000_B18","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/cr.2017.87","article-title":"Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart","volume":"27","author":"Abdul-Ghani","year":"2017","journal-title":"Cell Res."},{"key":"2021113011042548000_B19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/bs.apcsb.2016.11.006","article-title":"Targeting IKK and NF-\u03baB for therapy","volume":"107","author":"Durand","year":"2017","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"2021113011042548000_B20","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021113011042548000_B21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.biocel.2009.12.016","article-title":"The resolution of inflammation: anti-inflammatory roles for NF-kappaB","volume":"42","author":"Lawrence","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021113011042548000_B22","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1096\/fj.201600859R","article-title":"Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob\/ob and diet-induced obese mice","volume":"31","author":"Mart\u00ednez-Fern\u00e1ndez","year":"2017","journal-title":"FASEB J."},{"key":"2021113011042548000_B23","first-page":"2758","article-title":"Maresin 1 ameliorates iron-deficient anemia in IL-10(-\/-) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6\/STAT3 pathway","volume":"8","author":"Wang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"2021113011042548000_B24","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/intimm\/5.11.1461","article-title":"Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice","volume":"5","author":"Powrie","year":"1993","journal-title":"Int. Immunol."},{"key":"2021113011042548000_B25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1572-0241.2005.40615.x","article-title":"Activation pattern of signal transducers and activators oftranscription (STAT) factors in inflammatory bowel diseases","volume":"100","author":"Mudter","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"2021113011042548000_B26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1053\/j.gastro.2005.05.018","article-title":"Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis","volume":"129","author":"Han","year":"2005","journal-title":"Gastroenterology"},{"key":"2021113011042548000_B27","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/imm.12939","article-title":"Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome","volume":"155","author":"Celiberto","year":"2018","journal-title":"Immunology"},{"key":"2021113011042548000_B28","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1253\/circj.69.1412","article-title":"SOCS1\/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo","volume":"69","author":"Tanimoto","year":"2005","journal-title":"Circ. J."},{"key":"2021113011042548000_B29","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.chom.2018.03.011","article-title":"Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids","volume":"23","author":"Martinez-Guryn","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2021113011042548000_B30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/apha.12674","article-title":"Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells","volume":"217","author":"L\u00f3pez-Yoldi","year":"2016","journal-title":"Acta Physiol. (Oxf.)"},{"key":"2021113011042548000_B31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/MOG.0000000000000422","article-title":"Obesity and inflammatory bowel disease: diagnostic and therapeutic implications","volume":"34","author":"Swanson","year":"2018","journal-title":"Curr. Opin. Gastroenterol."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/132\/20\/2169\/450404\/cs-2017-1626c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/132\/20\/2169\/450404\/cs-2017-1626c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:58:37Z","timestamp":1638273517000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/132\/20\/2169\/72149\/Potential-clinical-treatment-of-colitis-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,19]]},"references-count":31,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2018,10,31]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20171626","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,19]]}}}