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In this review, we focus on the mechanisms promoting albuminuria, and the predictors and new markers of de novo albuminuria, as well as the potential treatment options to counteract the excretion of albumin. The increase in risk that accompanies de novo albuminuria supports the search for early markers and predictors that will allow practising physicians to assess and prevent the development of de novo albuminuria in their patients.<\/jats:p>","DOI":"10.1042\/cs20180097","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:15:33Z","timestamp":1523034933000},"page":"739-758","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Translational science in albuminuria: a new view of<i>de novo<\/i>albuminuria under chronic RAS suppression"],"prefix":"10.1042","volume":"132","author":[{"given":"Montserrat","family":"Baldan-Martin","sequence":"first","affiliation":[{"name":"Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos (HNP), SESCAM, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rodr\u00edguez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Cardiorenal Translational Laboratory, Instituto de Investigaci\u00f3n i+12, Hospital Universitario 12 de Octubre, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gonz\u00e1lez-Calero","sequence":"additional","affiliation":[{"name":"Department of Immunology, IIS-Fundacion Jimenez Diaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Ruilope","sequence":"additional","affiliation":[{"name":"Cardiorenal Translational Laboratory, Instituto de Investigaci\u00f3n i+12, Hospital Universitario 12 de Octubre, Madrid, Spain"},{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Universidad Aut\u00f3noma de Madrid\/IdiPAZ and CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain"},{"name":"School of Doctoral Studies and Research, Universidad Europea de Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Alvarez-Llamas","sequence":"additional","affiliation":[{"name":"Department of Immunology, IIS-Fundacion Jimenez Diaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda G.","family":"Barderas","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos (HNP), SESCAM, Toledo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Ruiz-Hurtado","sequence":"additional","affiliation":[{"name":"Cardiorenal Translational Laboratory, Instituto de Investigaci\u00f3n i+12, Hospital Universitario 12 de Octubre, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"2021113010594255400_B1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrcardio.2011.157","article-title":"Current challenges in the clinical management of hypertension","volume":"9","author":"Ruilope","year":"2011","journal-title":"Nat. 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