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Through histological analysis, we found loss of the mucosa\u2019s superficial epithelium, which became gradually normalized during the recovery period. Proliferation of gastric mucosa occurred with augmented formation of \u03b2-oxidation by-products, diminished synthesis of triacylglycerols (TGs), as well as of phospholipids, and a reduced cytoplasmic NAD\/NADH ratio, whereas the mitochondrial redox NAD\/NADH ratio was much less affected. In addition, \u03b1-tocopherol increased palmitic acid utilization in the gastric mucosa, which was accompanied by the induction of \u2018mirror image\u2019 effects on the cell redox state, reflected in an inhibited cell gastric mucosa proliferation by the vitamin administration. In conclusion, the present study shows, for the first time, the role of lipid metabolism in the adaptive cell gastric mucosa changes that drive proliferation after a chronic insult. Moreover, \u03b1-tocopherol increased gastric mucosa utilization of palmitic acid associated with energy production. These events could be associated with its antioxidant properties in co-ordination with regulation of genes and cell pathways, including changes in the cell NAD\/NADH redox state.<\/jats:p>","DOI":"10.1042\/cs20180154","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T14:10:18Z","timestamp":1526566218000},"page":"1281-1296","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High \u03b1-tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ethanol treatment"],"prefix":"10.1042","volume":"132","author":[{"given":"Marisela","family":"Olgu\u00edn-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, y de, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Apartado Postal 70-243, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego\u00a0R.","family":"Hern\u00e1ndez-Espinosa","sequence":"additional","affiliation":[{"name":"Departamento de Neurodesarrollo y Fisiolog\u00eda, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Apartado Postal 70-243, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Hern\u00e1ndez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Desarrollo, y de, Instituto de Fisiolog\u00eda Celular, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Apartado Postal 70-243, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"2021113011033968400_B1","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.freeradbiomed.2006.07.013","article-title":"Rate of oxidant stress regulates balance between rat gastric mucosa proliferation and apoptosis","volume":"41","author":"Olgu\u00edn-Mart\u00ednez","year":"2006","journal-title":"Free Radic. 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