{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T20:46:08Z","timestamp":1699389968701},"reference-count":7,"publisher":"Portland Press Ltd.","issue":"17","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,9,14]]},"abstract":"<jats:p>The roles of the kidney are well defined, if there is a progressive loss in renal function, the kidney is no longer able to perform the listed tasks and chronic kidney disease (CKD) persists. In both clinical and experimental studies, NaHCO3 supplementation has been shown to improve glomerular filtration rate (GFR) as well as halt the progression toward end-stage renal disease (ESRD). In an article recently published in Clinical Science (vol 132 (11) 1179-1197), Ray et al. presented an intriguing and timely study, which investigates the mechanisms involved in the protection that follows oral NaHCO3 ingestion. Here we comment on their research findings.<\/jats:p>","DOI":"10.1042\/cs20180292","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T08:56:55Z","timestamp":1537088215000},"page":"1999-2001","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Buffering chronic kidney disease with sodium bicarbonate"],"prefix":"10.1042","volume":"132","author":[{"given":"Emily\u00a0N.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisa\u00a0W.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"2021113011023507100_B1","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1681\/ASN.2008111205","article-title":"Bicarbonate supplementation slows progression of CKD and improves nutritional status","volume":"20","author":"deBrito-Ashurst","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011023507100_B2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/ki.2013.401","article-title":"Bicarbonate therapy for prevention of chronic kidney disease progression","volume":"85","author":"Loniewski","year":"2014","journal-title":"Kidney Int."},{"key":"2021113011023507100_B3","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1681\/ASN.2007121271","article-title":"High perfusion pressure accelerates renal injury in salt-sensitive hypertension","volume":"19","author":"Mori","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021113011023507100_B4","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.4049\/jimmunol.1701605","article-title":"Oral NaHCO3 activates a splenic anti-inflammatory pathway: evidence that cholinergic signals are trasmitted via mesothelial cells","volume":"200","author":"Ray","year":"2018","journal-title":"J. Immunol."},{"key":"2021113011023507100_B5","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171630","article-title":"Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats","author":"Ray","year":"2018","journal-title":"Clin. Sci."},{"key":"2021113011023507100_B6","volume-title":"National Chronic Kidney Disease Fact Sheet, 2017","author":"Stats","year":"2017"},{"key":"2021113011023507100_B7","first-page":"11","article-title":"Preciptable tissue proteins can cause experimental acute renal failure","volume":"59","author":"Zager","year":"1988","journal-title":"Lab. Invest."}],"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/132\/17\/1999\/450319\/cs-2018-0292c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/132\/17\/1999\/450319\/cs-2018-0292c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:02:49Z","timestamp":1638270169000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/132\/17\/1999\/72092\/Buffering-chronic-kidney-disease-with-sodium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":7,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9,14]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20180292","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]}}}