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In this review, we will sum up recent advances on the modification, regulation, and implication of histone modifications and DNA methylation in I\/R injury-induced organ dysfunction. Understandings of I\/R-induced epigenetic alterations and regulations will aid in the development of potential therapeutics.<\/jats:p>","DOI":"10.1042\/cs20180465","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T08:35:13Z","timestamp":1551083713000},"page":"597-609","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Histone acetylation and DNA methylation in ischemia\/reperfusion injury"],"prefix":"10.1042","volume":"133","author":[{"given":"Jinhua","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-4187","authenticated-orcid":false,"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"},{"name":"Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"2021113011093986800_B1","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. 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